Detalhe da pesquisa
1.
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.
Cell
; 147(4): 840-52, 2011 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-22035958
2.
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.
EMBO J
; 40(3): e105001, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33349959
3.
Acetylation targets mutant huntingtin to autophagosomes for degradation.
Cell
; 137(1): 60-72, 2009 Apr 03.
Artigo
Inglês
| MEDLINE | ID: mdl-19345187
4.
Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
PLoS Genet
; 14(10): e1007682, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30296255
5.
Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy.
BMC Biol
; 18(1): 127, 2020 09 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32938453
6.
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.
Am J Hum Genet
; 100(2): 297-315, 2017 02 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28132687
7.
Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics.
J Neurogenet
; 34(3-4): 453-465, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32811254
8.
Decreased function of survival motor neuron protein impairs endocytic pathways.
Proc Natl Acad Sci U S A
; 113(30): E4377-86, 2016 07 26.
Artigo
Inglês
| MEDLINE | ID: mdl-27402754
9.
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.
BMC Neurosci
; 19(1): 10, 2018 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29523076
10.
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Genes Dev
; 24(13): 1403-17, 2010 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20595232
11.
Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.
Proc Natl Acad Sci U S A
; 110(26): E2371-80, 2013 Jun 25.
Artigo
Inglês
| MEDLINE | ID: mdl-23757500
12.
The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.
J Neurosci
; 33(15): 6557-62, 2013 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-23575853
13.
Conserved genes act as modifiers of invertebrate SMN loss of function defects.
PLoS Genet
; 6(10): e1001172, 2010 Oct 28.
Artigo
Inglês
| MEDLINE | ID: mdl-21124729
14.
Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants.
MicroPubl Biol
; 20232023.
Artigo
Inglês
| MEDLINE | ID: mdl-37351305
15.
Local RNA translation at the synapse and in disease.
J Neurosci
; 31(45): 16086-93, 2011 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-22072660
16.
Optical interrogation of neural circuits in Caenorhabditis elegans.
Nat Methods
; 6(12): 891-6, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19898486
17.
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Nature
; 442(7103): 700-4, 2006 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-16799563
18.
Starting a C. elegans Research Laboratory: Practical Advice.
Methods Mol Biol
; 2468: 1-24, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35320557
19.
The use of CRISPR to generate a whole-gene humanized MAPT and the examination of P301L and G272V clinical variants, along with the creation of deletion null alleles of ptl-1, pgrn-1 and alfa-1 loci.
MicroPubl Biol
; 20222022.
Artigo
Inglês
| MEDLINE | ID: mdl-36204657
20.
Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis.
Cell Rep
; 38(4): 110195, 2022 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-35081350