The Impact of Loving-Kindness Meditation on Job-Related Burnout of Nurses Working in Neonatal Intensive Care Unit: A Randomized Clinical Trial Study.

Job-related burnout is one health outcome in nurses working in neonatal intensive care units (NICUs) due to the heavy workload, which results in negative physical and psychological consequences. One newly introduced approach to improve coping is loving-kindness meditation (LKM). Some studies have shown the effectiveness of the LKM on the mental health of nurses, though more evidence is required to support them. This study aimed to investigate the effectiveness of the LKM on job-related burnout of nurses working in NICU. This clustered controlled randomized clinical trial assessed job-related burnout before and after a month of practicing LKM guided through a virtual method. A total of 66 eligible NICU nurses from 2 referral children hospitals in Tehran were randomly assigned to 2 control (n = 33) and intervention (n = 33) groups. The intervention was performed 3 times a week for 1 month in the form of 20-minute audio files of LKM for the intervention group, and educational files on mental health during the COVID-19 pandemic were sent to the control group. The instruments used in this study were the demographic information questionnaire and the Maslach Burnout Inventory, which participants completed before and after the intervention. The mean difference in the overall scores of burnout before and after the intervention in the intervention group was significantly reduced (P = .003), but no significant difference was observed in the control group (P = .018). These findings support the benefit of LKM in NICU nurses in reducing burnout.

The Impact of Loving-Kindness Meditation on Compassion Fatigue of Nurses Working in the Neonatal Intensive Care Unit: A Randomized Clinical Trial Study.

Compassion fatigue is a common complication in nurses, which can lead to burnout, job dissatisfaction, and a decline in the quality of patient care. This study aimed to investigate the impact of loving-kindness meditation on compassion fatigue of nurses working in the neonatal intensive care unit (NICU). This cluster-blinded randomized clinical trial study was conducted on 66 NICU nurses in 2 educational hospitals selected. The intervention group received a 1-month online program for daily training and practice of loving-kindness meditation. The control group received miscellaneous files on mental health during the COVID-19 pandemic period. The Nursing Compassion Fatigue Inventory (NCFI) was filled out by the 2 groups, before and after the intervention. The results showed that the mean scores of the NCFI in the intervention group decreased significantly compared with before the intervention (P = .002). In comparison with the control group, there was a significant difference between the mean scores of the 2 groups after the intervention (P = .034). Among nurses working in NICU, loving-kindness meditation significantly reduces compassion fatigue after 1 month. These findings support the use of this intervention for nurses.

A Study of Associations Between rs9349379 (PHACTR1), rs2891168 (CDKN2B-AS), rs11838776 (COL4A2) and rs4880 (SOD2) Polymorphic Variants and Coronary Artery Disease in Iranian Population.

Recent genome-wide association studies reported the association of polymorphic alleles of PHACTR1 (rs9349379 (G)), CDDKN2B-AS1 (rs2891168 (G)), COL4A2 (rs11838776 (A)) and SOD2 (rs4880 (T)) with increased risk of coronary artery disease (CAD). The aim of our study was to assess the association of genetic variants with risk of CAD and its severity and in Southeast Iranian population. This study was examined in 250 CAD-suspected patients (mean age 53.49 ± 6.9 years) and 250 healthy individuals (mean age 52.96 ± 5.9 years). The Taqman SNP genotyping assay was used for genotyping of rs9349379 and rs2891168 variants. Tetra-primer Amplified refractory mutation system-PCR (Tetra-primer ARMS-PCR) was employed for rs11838776 and rs4880. Multivariate logistic regression analyses indicated that the G allele of rs9349379 and rs2891168 were associated with increased risk of CAD. The GG homozygous genotype of rs9349379 and rs2891168 had also been associated with risk of CAD. Additionally, the AG genotype of rs2891168 was associated with CAD. The significance of association of rs2891168 (G, GG, AG) increases with severity of CAD; but the rs9349379 (G, GG) have shown reverse association with severity of CAD. The genetic variants of COL4A2 (rs11838776) and SOD2 (rs4880) reflected no association with CAD in Southeast Iranian population. The findings of this study revealed that the PHACTR1 (rs9349379) and CDKN2B-AS1 (rs2891168) genetic variants might serve as genetic risk factor in CAD.

Silica-Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment.

Prostate cancer (PCa) is one of the most commonly diagnosed cancers and is the fifth common cause of cancer-related mortality in men. Current methods for PCa treatment are insufficient owing to the challenges related to the non-specificity, instability and side effects caused by the drugs and therapy agents. These drawbacks can be mitigated by the design of a suitable drug delivery system that can ensure targeted delivery and minimise side effects. Silica based nanoparticles (SBNPs) have emerged as one of the most versatile materials for drug delivery due to their tunable porosities, high surface area and tremendous capacity to load various sizes and chemistry of drugs. This review gives a brief overview of the diagnosis and current treatment strategies for PCa outlining their existing challenges. It critically analyzes the design, development and application of pure, modified and hybrid SBNPs based drug delivery systems in the treatment of PCa, their advantages and limitations.

Improvement of Rat Sperm Chromatin Integrity and Spermatogenesis with Omega 3 following Bleomycin, Etoposide and Cisplatin Treatment.

The objective of this study is to examine the effects of omega 3 treatment on rat sperm chromatin condensation, DNA damage and spermatogenesis after bleomycin, etoposide and cisplatin (BEP) treatment. In this experimental study, 40 male rats were divided into four groups: Control, BEP, Omega 3 and BEP + Omega 3. Sperm chromatin condensation and DNA damage were assessed using aniline blue and acridine orange staining, respectively. Results show that the mean percentage of sperms with excessive histone and DNA damage was significantly increased in the BEP group after 9 weeks as compared to control group (p˂0.001). While, in the BEP + Omega 3 group, the mean percentage of sperm with excessive histone and DNA damage was decreased significantly compared with BEP group (p˂0.001). The testicular histomorphometric analysis indicated that omega 3 has a significant effect on the mean number of spermatogonia, primary spermatocytes, leydig cells and testicular histology properties following BEP treatment. The mean count of aforementioned cells significantly increased after omega 3 treatment compared with the BEP group (p˂0.001). Our data indicated omega 3 may be had beneficial effect for improving chromatin condensation, DNA damage during spermatogenesis and testicular histomorphic properties following BEP treatment.

"NMDA receptor spectrum disorder" in the differential diagnosis of demyelinating disorders of the CNS: optic neuritis and myelitis.

OBJECTIVE: The aim of this study was to investigate the frequency of anti-N-methyl-D-aspartate receptor (anti-NMDAR) antibody positivity in patients presenting with transverse myelitis (TM) and/or optic neuritis (ON), to describe their neurologic and radiological characteristics, and to compare these characteristics with those reported in previous studies. MATERIAL AND METHODS: This study included 179 patients (ON: 96, TM: 74, ON and TM: 9) who visited Isfahan Multiple Sclerosis Center from January 2017 to September 2019, for approximately 32 months. The respective neurological examinations were performed. Demographic data of the patients, as well as findings from radiological and serological investigations were obtained. RESULTS: Frequencies of anti-NMDAR seropositivity in patients with TM, ON, and concurrent TM and ON were approximately 3.4%, 1.4%, and 11.1%, respectively. None exhibited any psychiatric symptoms. CONCLUSION: Based on the frequency of seropositivity for anti-NMDAR antibody in our patients, positivity for this antibody appears to be more frequent than previously anticipated in patients presenting with these conditions. We recommend that the anti-NMDAR antibody presence in CSF/serum be checked and considered in addition to the routine examinations performed upon confronting demyelinating conditions such as TM and ON. We suggest considering the term "NMDAR spectrum disorder" to more clearly distinguish the potentially overlapping conditions with different etiologies in patients with CNS disorders.

Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial.

AIM: Depression has been recognized as one of the disorders associated with cardiac interventions such as percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). In the present study, we evaluated the efficacy and safety of sulforaphane in treatment of depression induced by cardiac interventions. METHODS: After initial screening, 66 patients with previous history of at least one cardiac intervention and current mild to moderate depression were randomly assigned to two parallel groups receiving either sulforaphane (n = 33) or placebo (n = 33) for six successive weeks. Efficacy was assessed using the Hamilton Rating Scale for Depression (HAM-D) at baseline and week 2, 4, and 6. Safety of the treatments was checked during the trial period. RESULTS: Sixty participants completed the clinical trial (n = 30 in each group). Baseline demographic and clinical parameters were all similar among groups. Repeated measures analysis indicated that the sulforaphane group exhibited greater improvement in HAM-D scores throughout the trial (P < 0.001). Response to treatment (≥50% reduction in the HAM-D score) rate was higher in the sulforaphane group at trial endpoint (30% vs 6.67%, P = 0.042). Remission (HAM-D score ≤ 7) rate was also higher in the sulforaphane group; however, the difference was not significant (23.33% vs 3.33%, P = 0.052). Finally, no significant difference was observed between the two groups in terms of frequency of side effects. CONCLUSIONS: Sulforaphane could safely improve depressive symptoms induced by cardiac interventions. Further clinical trials with larger sample sizes and longer follow-up periods are warranted to confirm our results.

Rheological response of a modified polyacrylamide-silica nanoparticles hybrid at high salinity and temperature.

Water-soluble polyacrylamides have often been used to modify flow response in various water-based technologies and industrial processes, including paints, water treatment, paper manufacturing, and chemical enhanced oil recovery. Polymers are susceptible to degradation at combined high salinity and elevated temperature conditions which limits their overall performance. Hybrid mixtures of hydrophobically modified polyacrylamide (HMPAM) with hydrophobically modified silica nanoparticles (NPs) emerged as a promising strategy for achieving enhanced stability and high viscosity in brines having a high total dissolved solids (TDS) content and high hardness at elevated temperatures (>20 wt% TDS, including >1.5 wt% divalent cations at T > 70 °C). The rheological response of the hybrids at various concentrations of HMPAM and NPs was examined to investigate the synergic effects. Hybridization of HMPAM with NPs led to a higher viscosity at high salinity and elevated temperature. The viscosity improvement was more pronounced when the concentration of HMPAM was in the semi-dilute regime and concentration of NPs was higher than a critical threshold where the viscosity increased roughly by a factor of 1.5. Here we present the mechanisms of improved viscosity behaviour. The rheological data suggest the role of NPs in the bridging between HMPAM molecules, which in turn increases the hydrodynamic radius and consequently the viscosity of the hybrids.

Massive hemoptysis in a pregnant woman: the first rare presentation of mitral valve stenosis.

Massive hemoptysis is one of the rare manifestations of mitral valve stenosis. Massive hemoptysis is considered as a potentially life threatening that frequently needs emergency procedures. A 43- year-old pregnant woman presented with coughing and massive hemoptysis. She was diagnosed severe rheumatic mitral stenosis. The patient underwent percutaneous transluminal mitral valvuloplasty (PTMC). Before ICU admission and hospitalization, she was healthy, without any past medical history and complaints.

The Protective Effects of Omega3 on Ubiquitination and Protamination of Rat Sperm after Bleomycin, Etoposide, and Cisplatin Treatment.

The purpose of this study is evaluation the protective effect of omega3 on rat sperm protamination and ubiquitination after treatment with Bleomycin, Etoposide and Cisplatin (BEP) drugs. In present study, 40 male rats were divided into four groups: Control, BEP, Omega3 and BEP + Omega3. Sperm protamination and ubiquitination were assessed using chromomycin A3 and immunofluorescence staining respectively. The mean percentage of ubiquitinated sperm in BEP group was significantly increased relative to control group (P < .001). But, the mean percentage of sperm protamination significantly decreased in BEP group relative to control group (P < .001). Rats in BEP + Omega3 group showed a significantly decreased in the mean percentage of sperm ubiquitination as compared to BEP group (P < .05) while, sperm protamination increased significantly relative to BEP group (P < .001). Administration of Omega3 after chemotherapy showed an improvement in sperm ubiquitination and protamination. Our data indicated that omega3 after chemotherapy may be beneficial for chromatin remodeling during spermatogenesis following BEP treatment.

A combination of dispersive liquid-liquid microextraction and surface plasmon resonance sensing of gold nanoparticles for the determination of ziram pesticide.

We have developed a reliable, fast, and highly sensitive analytical method utilizing dispersive liquid-liquid microextraction and gold nanoparticles probes for ziram (zinc bis(dimethyldithiocarbamate)) determination. The method is based on the in situ formation of gold nanoparticles in carbon tetrachloride as an organic phase. It was found that the trace levels of ziram influenced the formation of gold nanoparticles, leading to absorbance change of a sedimented phase. The results of the colorimetric ziram determination were in the concentration range of 0.12-2.52 ng/mL with a limit of detection of 0.06 ng/mL. The formation of the stable and dispersed gold nanoparticles in the organic phase provides a good precision for dispersive liquid-liquid microextraction method, resulting in the relative standard deviation of 3.8 and 1.2% for 0.56 and 1.58 ng/mL of ziram, respectively. This method has been successfully used for the ziram determination in samples of well and river water, soil, potato, carrot, wheat, and paddy soil.

Reducing uncertainty of estimated nitrogen load reductions to aquatic systems through spatially targeting agricultural mitigation measures using groundwater nitrogen reduction.

The need to further abate agricultural nitrate (N)-loadings to coastal waters in Denmark represents the main driver for development of a new spatially targeted regulation that focus on locating N-mitigation measures in agricultural areas with high N-load. This targeting makes use of the spatial variation across the landscape in natural N-reduction (denitrification) of leached nitrate in the groundwater and surface water systems. A critical basis for including spatial targeting in regulation of N-load in Denmark is the uncertainty associated with the effect of spatially targeting measures, since the effect will be critically affected by uncertainty in the quantification of the spatial variation in N-reduction. In this study, we used 30 equally plausible N-reduction maps, at 100 m grid and sub-catchment resolutions, for the 85-km2 groundwater dominated Norsminde catchment in Denmark, applying set-aside as the measure on high N-load areas to reach a N-load reduction target of 20%. The uncertainty on these N-reduction maps resulted in uncertainty on the estimated N-load and on the required set-aside area. We tested several methods for spatially targeting set-aside that took into account the uncertainty on set-aside area and developed methods to reduce uncertainty on the estimated N-load reductions. These methods includes application of set-aside based on each individual N-reduction map compared to a mean N-reduction map, using spatial frequency of high N-load and using spatial frequency of low N-reduction. The results revealed that increasing the ensemble size for averaging the N-reduction maps would decrease the uncertainty on the estimated set-aside area with a stable effect when using an ensemble of 15 or more maps. The spatial resolution of the groundwater N-reduction map is essential for the effectiveness of set-aside, but uncertainty of the finer spatial resolution of N-reduction is greater compared to sub-catchment scale, and application of a spatially targeted strategy with uncertain N-reduction maps will result in incorrect set-aside area and uncertain estimations of N-load reductions. To reduce the uncertainty on estimated N-load reductions, this study finds the method of set-aside application based on spatial frequency of high N-load to be more effective than other methods tested.

Spatially differentiated strategies for reducing nitrate loads from agriculture in two Danish catchments.

Nutrient loss from agriculture is the largest source of diffuse water pollution in Denmark. To reduce nutrient loads a number of solutions have been implemented, but this has been insufficient to achieve the environmental objectives without unacceptable repercussions for agricultural production. This has substantiated the need to develop a new approach to achieve nitrogen (N) load reduction to the aquatic environments with lower costs to farmers. The new approach imply targeting N leaching mitigation to those parts of the landscape which contribute most to the N-loadings. This would involve either reducing the source loading or enhancing the natural reduction (denitrification) of N after it is leached from the root zone of agricultural crops. In this study, a new method of spatially differentiated analysis for two Danish catchments (Odense and Norsminde) was conducted that reach across the individual farms to achieve selected N-load reduction targets. It includes application of cover crops within current crop rotations, set-a-side application on high N-load areas, and changes in agricultural management based on maps of N-reduction available for two different spatial scales, considering soil type and farm boundaries as spatial constraints. In summary, the results revealed that considering spatial constraints for changes in agricultural management will affect the effectiveness of N-load reduction, and the highest N-load reduction was achieved where less constraints were considered. The results also showed that the range of variation in land use, soil types, and N-reduction potential influence the reduction of N-loadings that can originate from critical source areas. The greater the spatial variation the greater the potential for N load reduction through targeting of measures. Therefore, the effectiveness of spatially differentiated measures in term of set-a-side area in Odense catchment were relatively greater compared to Norsminde catchment. The results also showed that using a fine spatial N-reduction map provides greater potential for N load reductions compared to using sub-catchment scale N-reduction maps.

Misinterpretation in Nanotoxicology: A Personal Perspective.

As an emerging field, nanotoxicology is gaining significant interest from scientists as well as from international regulatory firms in an attempt to build accumulated knowledge on this topic, which will be the basis for regulatory codes and safer nanotechnology. However, conflicting results and findings are abundant in the literature calling for more careful experimental design, result interpretation, and detailed reporting. In this perspective, we focus on misinterpretation in nanotoxicology and highlight the importance of proper experimental practice to avoid artifacts by discussing various examples from the literature.

Comparing the effect of swaddling and breastfeeding and their combined effect on the pain induced by BCG vaccination in infants referring to Motahari Hospital, Jahrom, 2010-2011.

BACKGROUND AND AIM: Despite the clinical importance of pain, many neonates are subjected to numerous painful invasive procedures and their complications as part of their care. This study has been designed to investigate the effect of swaddling and breastfeeding, and their combined effect on the pain induced by BCG vaccination in healthy term infants. METHOD: This randomized double-blind intervention study was performed on 131 healthy term neonates in Motahari Hospital of Jahrom. The samples were randomly assigned into three intervention groups and a control group. The infants in the swaddled group were swaddled 2 minutes before and 2 minutes after vaccination. The infants in the breastfed group were breastfed within 45 minutes before vaccination. The infants in the combination group were both breast fed before and swaddled within vaccination but the infants in the control group were vaccinated without any intervention. Heart rate and oxygen saturation level of neonates were recorded in the 3 phases of: baseline, injection and 2 minutes after injection. Furthermore, the neonates' faces were recorded using a video camera. Then pain intensity was measured by Neonatal Facial Coding System (NFCS). Mean Score of pain intensity and physiological responses of subjects were statistically analyzed using non parametrical Kruskal-Wallis test and Mann-Whitney. RESULTS: The mean of pain intensity (NFCS) and changes in the heart rate at injection time to the baseline in the three intervention groups in comparison with the control group showed statistically significant difference (p=0.003 and p=0.002 respectively). However changes in blood oxygen saturation level, were not statistically significant difference between four groups. CONCLUSION: Regarding to the significant impact of both breastfeeding and swaddling on the pain reduction of vaccination, it is recommended to take benefit of these two safe and available non-pharmacological methods in order to relief pain during painful procedures.

The association between visual impairment and mental disorders.

To determine the association between visual impairment (VI) and some mental disorders using the general health questionnaire (GHQ) in individuals aged 60 years and above in Tehran, Iran. The present population-based cross-sectional study was conducted on people aged 60 and older in Tehran, Iran using multi-stage cluster sampling. After selecting the samples, examinations including visual acuity measurement, refraction, and slit-lamp biomicroscopy were performed for all participants. The GHQ was used to examine mental disorders. Simple and multiple linear regressions were used to investigate the association between VI and mental disorders. Of the 3740 invitees, 3310 participated in the study (response rate: 88.50%). After applying the exclusion criteria, 2789 individuals were analyzed for this report. Mean score of physical, anxiety, social and depression disorders in people with and without VI was 3.74 ± 2.03, 5.81 ± 2.79, 7.56 ± 1.91, 1.32 ± 1.90, and 3.14 ± 1.76, 4.93 ± 2.71, 8.09 ± 1.99, 0.91 ± 1.38, respectively. The total score of GHQ in participants with and without VI was 18.43 ± 4.75 and 17.07 ± 4.19, respectively. The association between GHQ subscales and total GHQ score with VI by multiple linear regression showed that VI had a statistically significant direct association with physical symptoms (ß = 0.37; 95% CI 0.12 to 0.62) and anxiety (ß = 0.48; 95% CI 0.16 to 0.81). Nevertheless, depression had a borderline association with VI (ß = 0.21; 95% CI - 0.03 to 0.45) and social dysfunction did not have a statistically significant association with VI in the final linear regression model and did not remain in the model. Total GHQ score had a statistically significant association with VI (ß = 1.02; 95% CI 0.39 to 1.64) in the presence of covariates. Regarding the association between VI and GHQ components, the physical symptoms had the highest R2 (R2 = 0.159). Patients with VI suffer more from anxiety, depression, and physical symptoms regardless of age, sex, education, and other effective variables. The coincidence of aging with VI and the association of VI with mental disorders emphasizes the importance of a broader view of the elderly and the aging process.

The impact of educating parents of leukaemic children on the healthy siblings' quality of life.

OBJECTIVE: To study the effect of educational programme for the parents on the quality of life of healthy siblings of children with leukaemia. METHODS: The quasi-experimental study was conducted from January to July 2006 at the Oncology Ward of Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Iran. It involved two groups of siblings of children with leukaemia. Parents of the children participated in 3 educational sessions and the quality of life of their healthy children was surveyed before and after education.The data was collected through a questionnairedeveloped by The Netherlands Organisation for Aplied Scientific Research Academic Medical Centre (TN0-AZ1) which has been specially designed for children aged 7-15 years. In this study, the parent form of the questionnaire, including 7 dimensions, was used. Sampling was done by convenient purposive method. The collected data were analysed using SPSS 11.5. RESULTS: The differences in the quality of life scores of the experimental and control groups before and after education was -28.8 +/- 11.3 and -3.6 +/- 4.5, respectively. Also by regarding the mean difference of the two groups, the independent t-test showed significant difference before and after the education (p < 0.01). There was a significant difference between the two groups on all dimensions (p < 0.01) in such a way that the educational interventions was able to improve the quality of life in terms of physical complaints, autonomy, social, cognitive and motor functioning, positive and negative emotions. CONCLUSION: The educational programme was effective in improving the quality of life and its dimensions among healthy siblings of children with leukaemia.

Organic conversion tea farms can have comparable economic benefits and less environmental impacts than conventional ones-A case study in China.

Lack of experience concerning the organic conversion period and its associated challenges have made it difficult for conventional farmers to convert to organic farming. In this study, using a combined life cycle assessment (LCA) with data envelopment analysis (DEA) approach, we investigated farming management strategies, and environmental, economic, and efficiency impacts of organic conversion tea farms (OCTF, N = 15) compared to conventional (CTF, N = 13) and organic (OTF, N = 14) tea farms in Wuyi County, China for a year-round (2019). We found that the OCTF reduced agricultural inputs (environmental impacts) and applied more manual harvesting (increased added value) to pull through the conversion period. According to the LCA results, OCTF showed a similar integrated environmental impact index compared with OTF but significantly (P < 0.05) lower than CTF at both midpoint and endpoint levels. In terms of economic assessment, OTF showed the significantly highest total revenue (18.7 thousand $ ha-1 yr-1) and profit (13.7 thousand $ ha-1 yr-1) (P < 0.05) among the farm types. In contrast, OCTF and CTF did not show significant differences in relation to these economic indicators (P > 0.05). The total cost and cost-profit ratio did not show significant differences among the three farm types. Considering the DEA analysis, there were no significant differences in the technical efficiency of all farm types. However, the eco-efficiency of OCTF and OTF was significantly higher than that of CTF. Therefore, conventional tea farms can survive the conversion period with competitive economic and environmental benefits. In this regard, policies should promote organic tea cultivation and agroecological practices to enhance the sustainable transformation of tea production systems.

Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging.

The increasing prevalence of Alzheimer's disease (AD) has led to a health crisis. According to official statistics, more than 55 million people globally have AD or other types of dementia, making it the sixth leading cause of death. It is still difficult to diagnose AD and there is no definitive diagnosis yet; post-mortem autopsy is still the only definite method. Moreover, clinical manifestations occur very late in the course of disease progression; therefore, profound irreversible changes have already occurred when the disease manifests. Studies have shown that in the preclinical stage of AD, changes in some biomarkers are measurable prior to any neurological damage or other symptoms. Hence, creating a reliable, fast, and affordable method capable of detecting AD in early stage has attracted the most attention. Seeking clinically applicable, inexpensive, less invasive, and much more easily accessible biomarkers for early diagnosis of AD, blood-based biomarkers (BBBs) seem to be an ideal option. This review is an inclusive report of BBBs that have been shown to be altered in the course of AD progression. The aim of this report is to provide comprehensive insight into the research status of early detection of AD based on BBBs.