RESUMO
This report illustrates potential concerns regarding the administration of Argatroban (AGN), a small molecule, direct thrombin inhibitor, within the setting of multi-organ procurement (MOP). Herein, we outline the case of a large AGN bolus to the donor during MOP, and the passive transfer of a coagulopathy to the recipient of the transplanted liver. From this, we conclude that caution should be exercised when AGN is used in the setting of MOP.
Assuntos
Antitrombinas/farmacocinética , Rejeição de Enxerto/etiologia , Hepatite C/cirurgia , Transplante de Fígado , Fígado/metabolismo , Ácidos Pipecólicos/farmacocinética , Obtenção de Tecidos e Órgãos , Antitrombinas/efeitos adversos , Arginina/análogos & derivados , Transtornos da Coagulação Sanguínea/induzido quimicamente , Transtornos da Coagulação Sanguínea/terapia , Transfusão de Eritrócitos , Humanos , Masculino , Pessoa de Meia-Idade , Tempo de Tromboplastina Parcial , Ácidos Pipecólicos/efeitos adversos , Transfusão de Plaquetas , Tempo de Protrombina , Sulfonamidas , Distribuição Tecidual , Doadores de Tecidos , Adulto JovemRESUMO
Fifty-day-old female Sprague--Dawley rats were given carcinogenic and sub-carcinogenic doses of X-radiation to the mammary glands to evaluate the induction of a 60-kDa oncofetal protein (OFP-60). This protein has previously been shown to be produced in the target organ and released to circulation during chemical carcinogenesis and tumorigenesis. In a time course experiment, the mammary glands of the rats were irradiated with a single dose of 1.85 gray (Gy). The OFP-60 marker protein was detected in peripheral blood at 21 days post-irradiation. Irradiation of the mammary gland with single X-ray doses ranging from 0.22 to 1.85 Gy produced a linear relationship between X-ray dose and plasma concentration of OFP-60 determined at 21 days post-treatment. This initiation-related parameter correlates with the known linear relationship between dose of X-radiation and potential tumor incidence.