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1.
J Cogn Neurosci ; 36(1): 128-142, 2024 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-37977156

RESUMO

Visual speech plays a powerful role in facilitating auditory speech processing and has been a publicly noticed topic with the wide usage of face masks during the COVID-19 pandemic. In a previous magnetoencephalography study, we showed that occluding the mouth area significantly impairs neural speech tracking. To rule out the possibility that this deterioration is because of degraded sound quality, in the present follow-up study, we presented participants with audiovisual (AV) and audio-only (A) speech. We further independently manipulated the trials by adding a face mask and a distractor speaker. Our results clearly show that face masks only affect speech tracking in AV conditions, not in A conditions. This shows that face masks indeed primarily impact speech processing by blocking visual speech and not by acoustic degradation. We can further highlight how the spectrogram, lip movements and lexical units are tracked on a sensor level. We can show visual benefits for tracking the spectrogram especially in the multi-speaker condition. While lip movements only show additional improvement and visual benefit over tracking of the spectrogram in clear speech conditions, lexical units (phonemes and word onsets) do not show visual enhancement at all. We hypothesize that in young normal hearing individuals, information from visual input is less used for specific feature extraction, but acts more as a general resource for guiding attention.


Assuntos
Percepção da Fala , Humanos , Fala , Percepção Visual , Seguimentos , Pandemias , Estimulação Acústica
2.
Eur J Neurosci ; 60(1): 3812-3820, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38711271

RESUMO

Regularities in our surroundings lead to predictions about upcoming events. Previous research has shown that omitted sounds during otherwise regular tone sequences elicit frequency-specific neural activity related to the upcoming but omitted tone. We tested whether this neural response is depending on the unpredictability of the omission. Therefore, we recorded magnetencephalography (MEG) data while participants listened to ordered or random tone sequences with omissions occurring either ordered or randomly. Using multivariate pattern analysis shows that the frequency-specific neural pattern during omission within ordered tone sequences occurs independent of the regularity of the omissions. These results suggest that the auditory predictions based on sensory experiences are not immediately updated by violations of those expectations.


Assuntos
Estimulação Acústica , Percepção Auditiva , Magnetoencefalografia , Humanos , Masculino , Feminino , Magnetoencefalografia/métodos , Adulto , Percepção Auditiva/fisiologia , Estimulação Acústica/métodos , Adulto Jovem , Potenciais Evocados Auditivos/fisiologia , Córtex Auditivo/fisiologia
3.
Neuroimage ; 268: 119894, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-36693596

RESUMO

Listening to speech with poor signal quality is challenging. Neural speech tracking of degraded speech has been used to advance the understanding of how brain processes and speech intelligibility are interrelated. However, the temporal dynamics of neural speech tracking and their relation to speech intelligibility are not clear. In the present MEG study, we exploited temporal response functions (TRFs), which has been used to describe the time course of speech tracking on a gradient from intelligible to unintelligible degraded speech. In addition, we used inter-related facets of neural speech tracking (e.g., speech envelope reconstruction, speech-brain coherence, and components of broadband coherence spectra) to endorse our findings in TRFs. Our TRF analysis yielded marked temporally differential effects of vocoding: ∼50-110 ms (M50TRF), ∼175-230 ms (M200TRF), and ∼315-380 ms (M350TRF). Reduction of intelligibility went along with large increases of early peak responses M50TRF, but strongly reduced responses in M200TRF. In the late responses M350TRF, the maximum response occurred for degraded speech that was still comprehensible then declined with reduced intelligibility. Furthermore, we related the TRF components to our other neural "tracking" measures and found that M50TRF and M200TRF play a differential role in the shifting center frequency of the broadband coherence spectra. Overall, our study highlights the importance of time-resolved computation of neural speech tracking and decomposition of coherence spectra and provides a better understanding of degraded speech processing.


Assuntos
Inteligibilidade da Fala , Percepção da Fala , Humanos , Inteligibilidade da Fala/fisiologia , Percepção da Fala/fisiologia , Encéfalo/fisiologia , Percepção Auditiva , Cognição , Estimulação Acústica
4.
Psychophysiology ; 60(11): e14362, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37350379

RESUMO

The most prominent acoustic features in speech are intensity modulations, represented by the amplitude envelope of speech. Synchronization of neural activity with these modulations supports speech comprehension. As the acoustic modulation of speech is related to the production of syllables, investigations of neural speech tracking commonly do not distinguish between lower-level acoustic (envelope modulation) and higher-level linguistic (syllable rate) information. Here we manipulated speech intelligibility using noise-vocoded speech and investigated the spectral dynamics of neural speech processing, across two studies at cortical and subcortical levels of the auditory hierarchy, using magnetoencephalography. Overall, cortical regions mostly track the syllable rate, whereas subcortical regions track the acoustic envelope. Furthermore, with less intelligible speech, tracking of the modulation rate becomes more dominant. Our study highlights the importance of distinguishing between envelope modulation and syllable rate and provides novel possibilities to better understand differences between auditory processing and speech/language processing disorders.


Assuntos
Percepção da Fala , Fala , Humanos , Magnetoencefalografia , Ruído , Cognição , Estimulação Acústica , Inteligibilidade da Fala
5.
Cereb Cortex ; 32(21): 4818-4833, 2022 10 20.
Artigo em Inglês | MEDLINE | ID: mdl-35062025

RESUMO

The integration of visual and auditory cues is crucial for successful processing of speech, especially under adverse conditions. Recent reports have shown that when participants watch muted videos of speakers, the phonological information about the acoustic speech envelope, which is associated with but independent from the speakers' lip movements, is tracked by the visual cortex. However, the speech signal also carries richer acoustic details, for example, about the fundamental frequency and the resonant frequencies, whose visuophonological transformation could aid speech processing. Here, we investigated the neural basis of the visuo-phonological transformation processes of these more fine-grained acoustic details and assessed how they change as a function of age. We recorded whole-head magnetoencephalographic (MEG) data while the participants watched silent normal (i.e., natural) and reversed videos of a speaker and paid attention to their lip movements. We found that the visual cortex is able to track the unheard natural modulations of resonant frequencies (or formants) and the pitch (or fundamental frequency) linked to lip movements. Importantly, only the processing of natural unheard formants decreases significantly with age in the visual and also in the cingulate cortex. This is not the case for the processing of the unheard speech envelope, the fundamental frequency, or the purely visual information carried by lip movements. These results show that unheard spectral fine details (along with the unheard acoustic envelope) are transformed from a mere visual to a phonological representation. Aging affects especially the ability to derive spectral dynamics at formant frequencies. As listening in noisy environments should capitalize on the ability to track spectral fine details, our results provide a novel focus on compensatory processes in such challenging situations.


Assuntos
Percepção da Fala , Humanos , Estimulação Acústica , Lábio , Fala , Movimento
6.
Neuroimage ; 252: 119044, 2022 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-35240298

RESUMO

Multisensory integration enables stimulus representation even when the sensory input in a single modality is weak. In the context of speech, when confronted with a degraded acoustic signal, congruent visual inputs promote comprehension. When this input is masked, speech comprehension consequently becomes more difficult. But it still remains inconclusive which levels of speech processing are affected under which circumstances by occluding the mouth area. To answer this question, we conducted an audiovisual (AV) multi-speaker experiment using naturalistic speech. In half of the trials, the target speaker wore a (surgical) face mask, while we measured the brain activity of normal hearing participants via magnetoencephalography (MEG). We additionally added a distractor speaker in half of the trials in order to create an ecologically difficult listening situation. A decoding model on the clear AV speech was trained and used to reconstruct crucial speech features in each condition. We found significant main effects of face masks on the reconstruction of acoustic features, such as the speech envelope and spectral speech features (i.e. pitch and formant frequencies), while reconstruction of higher level features of speech segmentation (phoneme and word onsets) were especially impaired through masks in difficult listening situations. As we used surgical face masks in our study, which only show mild effects on speech acoustics, we interpret our findings as the result of the missing visual input. Our findings extend previous behavioural results, by demonstrating the complex contextual effects of occluding relevant visual information on speech processing.


Assuntos
Percepção da Fala , Fala , Estimulação Acústica , Acústica , Humanos , Boca , Percepção Visual
7.
Eur J Neurosci ; 55(11-12): 3288-3302, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-32687616

RESUMO

Making sense of a poor auditory signal can pose a challenge. Previous attempts to quantify speech intelligibility in neural terms have usually focused on one of two measures, namely low-frequency speech-brain synchronization or alpha power modulations. However, reports have been mixed concerning the modulation of these measures, an issue aggravated by the fact that they have normally been studied separately. We present two MEG studies analyzing both measures. In study 1, participants listened to unimodal auditory speech with three different levels of degradation (original, 7-channel and 3-channel vocoding). Intelligibility declined with declining clarity, but speech was still intelligible to some extent even for the lowest clarity level (3-channel vocoding). Low-frequency (1-7 Hz) speech tracking suggested a U-shaped relationship with strongest effects for the medium-degraded speech (7-channel) in bilateral auditory and left frontal regions. To follow up on this finding, we implemented three additional vocoding levels (5-channel, 2-channel and 1-channel) in a second MEG study. Using this wider range of degradation, the speech-brain synchronization showed a similar pattern as in study 1, but further showed that when speech becomes unintelligible, synchronization declines again. The relationship differed for alpha power, which continued to decrease across vocoding levels reaching a floor effect for 5-channel vocoding. Predicting subjective intelligibility based on models either combining both measures or each measure alone showed superiority of the combined model. Our findings underline that speech tracking and alpha power are modified differently by the degree of degradation of continuous speech but together contribute to the subjective speech understanding.


Assuntos
Percepção da Fala , Encéfalo , Mapeamento Encefálico , Humanos , Inteligibilidade da Fala
8.
Neuroimage ; 108: 265-73, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25562827

RESUMO

Experienced meditators are able to voluntarily modulate their state of consciousness and attention. In the present study, we took advantage of this ability and studied brain activity related to the shift of mental state. Electrophysiological activity, i.e. EEG, was recorded from 11 subjects with varying degrees of meditation experience during Zen meditation (a form of open monitoring meditation) and during non-meditation rest. On a behavioral level, mindfulness scores were assessed using the Mindfulness Attention and Awareness Scale (MAAS). Analysis of EEG source power revealed the so far unreported finding that MAAS scores significantly correlated with gamma power (30-250Hz), particularly high-frequency gamma (100-245Hz), during meditation. High levels of mindfulness were related to increased high-frequency gamma, for example, in the cingulate cortex and somatosensory cortices. Further, we analyzed the relationship between connectivity during meditation and self-reported mindfulness (MAAS). We found a correlation between graph measures in the 160-170Hz range and MAAS scores. Higher levels of mindfulness were related to lower small worldedness as well as global and local clustering in paracentral, insular, and thalamic regions during meditation. In sum, the present study shows significant relationships of mindfulness and brain activity during meditation indicated by measures of oscillatory power and graph theoretical measures. The most prominent effects occur in brain structures crucially involved in processes of awareness and attention, which also show structural changes in short- and long-term meditators, suggesting continuative alterations in the meditating brain. Overall, our study reveals strong changes in ongoing oscillatory activity as well as connectivity patterns that appear to be sensitive to the psychological state changes induced by Zen meditation.


Assuntos
Mapeamento Encefálico , Encéfalo/fisiologia , Meditação/psicologia , Atenção Plena , Adulto , Eletroencefalografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Processamento de Sinais Assistido por Computador
9.
Front Behav Neurosci ; 16: 957227, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36187380

RESUMO

Emotional stimuli, including faces, receive preferential processing and are consequently better remembered than neutral stimuli. Therefore, they may also be more resistant to intentional forgetting. The present study investigates the behavioral and electrophysiological consequences of instructions to selectively remember or forget angry and neutral faces. In an item-method directed forgetting experiment, angry and neutral faces were randomly presented to 25 student participants (4 males). Each face was followed by an instruction to either forget or remember it and the participants' EEG was recorded. Later, recognition memory was unexpectedly tested for all items. Behaviorally, both hit and false alarm rates were higher for angry alike than for neutral faces. Directed forgetting occurred for neutral and angry faces as reflected in a reduction of both recognition accuracy and response bias. Event-related potentials revealed a larger late positive potential (LPP, 450 - 700 ms) for angry than for neutral faces during face presentation and, in line with selective rehearsal of remember items, a larger LPP following remember than forget cues. Forget cues generally elicited a larger frontal N2 (280 - 400 ms) than remember cues, in line with the forget instruction eliciting conflict monitoring and inhibition. Selectively following angry faces, a larger cue-evoked P2 (180 - 280 ms) was observed. Notably, forget cues following angry faces elicited a larger late frontal positivity (450 - 700 ms) potentially signaling conflict resolution. Thus, whereas both angry and neutral faces are subject to directed forgetting, on a neural level, different mechanisms underlie the effect. While directed forgetting for neutral faces may be achieved primarily by selective rehearsal, directed forgetting of angry faces involves an additional late frontal positivity, likely reflecting higher cognitive demands imposed by forgetting angry faces.

10.
PLoS One ; 17(9): e0275585, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36178907

RESUMO

Visual input is crucial for understanding speech under noisy conditions, but there are hardly any tools to assess the individual ability to lipread. With this study, we wanted to (1) investigate how linguistic characteristics of language on the one hand and hearing impairment on the other hand have an impact on lipreading abilities and (2) provide a tool to assess lipreading abilities for German speakers. 170 participants (22 prelingually deaf) completed the online assessment, which consisted of a subjective hearing impairment scale and silent videos in which different item categories (numbers, words, and sentences) were spoken. The task for our participants was to recognize the spoken stimuli just by visual inspection. We used different versions of one test and investigated the impact of item categories, word frequency in the spoken language, articulation, sentence frequency in the spoken language, sentence length, and differences between speakers on the recognition score. We found an effect of item categories, articulation, sentence frequency, and sentence length on the recognition score. With respect to hearing impairment we found that higher subjective hearing impairment is associated with higher test score. We did not find any evidence that prelingually deaf individuals show enhanced lipreading skills over people with postlingual acquired hearing impairment. However, we see an interaction with education only in the prelingual deaf, but not in the population with postlingual acquired hearing loss. This points to the fact that there are different factors contributing to enhanced lipreading abilities depending on the onset of hearing impairment (prelingual vs. postlingual). Overall, lipreading skills vary strongly in the general population independent of hearing impairment. Based on our findings we constructed a new and efficient lipreading assessment tool (SaLT) that can be used to test behavioral lipreading abilities in the German speaking population.


Assuntos
Surdez , Perda Auditiva , Percepção da Fala , Humanos , Idioma , Linguística , Leitura Labial , Fala , Percepção Visual
11.
Psychophysiology ; 57(3): e13507, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31763700

RESUMO

Muscular activity recording is of high basic science and clinical relevance and is typically achieved using electromyography (EMG). While providing detailed information about the state of a specific muscle, this technique has limitations such as the need for a priori assumptions about electrode placement and difficulty with recording muscular activity patterns from extended body areas at once. For head and face muscle activity, the present work aimed to overcome these restrictions by exploiting magnetoencephalography (MEG) as a whole head myographic recorder (head magnetomyography, hMMG). This is in contrast to common MEG studies, which treat muscular activity as artifact in electromagnetic brain activity. In a first proof-of-concept step, participants imitated emotional facial expressions performed by a model. Exploiting source projection algorithms, we were able to reconstruct muscular activity, showing spatial activation patterns in accord with the hypothesized muscular contractions. Going one step further, participants passively observed affective pictures with negative, neutral, or positive valence. Applying multivariate pattern analysis to the reconstructed hMMG signal, we were able to decode above chance the valence category of the presented pictures. Underlining the potential of hMMG, a searchlight analysis revealed that generally neglected neck muscles exhibit information on stimulus valence. Results confirm the utility of hMMG as a whole head electromyographic recorder to quantify muscular activation patterns including muscular regions that are typically not recorded with EMG. This key advantage beyond conventional EMG has substantial scientific and clinical potential.


Assuntos
Emoções/fisiologia , Expressão Facial , Músculos Faciais/fisiologia , Cabeça/fisiologia , Magnetoencefalografia/métodos , Miografia/métodos , Músculos do Pescoço/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Adulto , Eletromiografia , Feminino , Humanos , Comportamento Imitativo , Magnetoencefalografia/normas , Masculino , Miografia/normas , Estudo de Prova de Conceito , Adulto Jovem
12.
Memory ; 16(8): 797-809, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18608977

RESUMO

An item-cued directed forgetting paradigm was used to investigate the ability to control episodic memory and selectively encode complex coloured pictures. A series of photographs was presented to 21 participants who were instructed to either remember or forget each picture after it was presented. Memory performance was later tested with a recognition task where all presented items had to be retrieved, regardless of the initial instructions. A directed forgetting effect--that is, better recognition of "to-be-remembered" than of "to-be-forgotten" pictures--was observed, although its size was smaller than previously reported for words or line drawings. The magnitude of the directed forgetting effect correlated negatively with participants' depression and dissociation scores. The results indicate that, at least in an item method, directed forgetting occurs for complex pictures as well as words and simple line drawings. Furthermore, people with higher levels of dissociative or depressive symptoms exhibit altered memory encoding patterns.


Assuntos
Sinais (Psicologia) , Rememoração Mental/fisiologia , Retenção Psicológica/fisiologia , Análise de Variância , Ansiedade/psicologia , Depressão/psicologia , Feminino , Humanos , Masculino , Memória de Curto Prazo/fisiologia , Escalas de Graduação Psiquiátrica , Psicofísica , Tempo de Reação , Adulto Jovem
13.
Cortex ; 103: 266-276, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29673783

RESUMO

When we observe other people's actions, a number of parietal and precentral regions known to be involved in the planning and execution of actions are recruited for example seen as power decreases in alpha and beta frequencies indicative of increased activation. It has been argued that this recruitment reflects the process of simulating the observed action, thereby providing access to the meaning of the action. Alternatively, it has been suggested that rather than providing access to the meaning of an action, parietal and precentral regions might be recruited as a consequence of action understanding. A way to distinguish between these alternatives is to examine where in the brain and at which time point it is possible to discriminate between different types of actions (e.g., pointing or grasping) irrespective of the way these are performed. To this aim, we presented participants with videos of simple hand actions performed with the left or right hand towards a target on the left or the right side while recording magnetoencephalography (MEG) data. In each trial, participants were presented with two subsequent videos (S1, S2) depicting either the same (repeat trials) or different (non-repeat trials) actions. We predicted that areas that are sensitive to the type of action should show stronger adaptation (i.e., a smaller decrease in alpha and beta power) in repeat in comparison to non-repeat trials. Indeed, we observed less alpha and beta power decreases during the presentation of S2 when the action was repeated compared to when two different actions were presented indicating adaptation of neuronal populations that are selective for the type of action. Sources were obtained exclusively in posterior occipitotemporal regions, supporting the notion that an early differentiation of actions occurs outside the motor system.


Assuntos
Lateralidade Funcional/fisiologia , Magnetoencefalografia , Rede Nervosa/fisiologia , Lobo Occipital/fisiologia , Desempenho Psicomotor/fisiologia , Lobo Temporal/fisiologia , Adulto , Mapeamento Encefálico , Feminino , Força da Mão , Humanos , Masculino , Adulto Jovem
14.
Curr Biol ; 28(9): 1453-1459.e3, 2018 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-29681475

RESUMO

Successful lip-reading requires a mapping from visual to phonological information [1]. Recently, visual and motor cortices have been implicated in tracking lip movements (e.g., [2]). It remains unclear, however, whether visuo-phonological mapping occurs already at the level of the visual cortex-that is, whether this structure tracks the acoustic signal in a functionally relevant manner. To elucidate this, we investigated how the cortex tracks (i.e., entrains to) absent acoustic speech signals carried by silent lip movements. Crucially, we contrasted the entrainment to unheard forward (intelligible) and backward (unintelligible) acoustic speech. We observed that the visual cortex exhibited stronger entrainment to the unheard forward acoustic speech envelope compared to the unheard backward acoustic speech envelope. Supporting the notion of a visuo-phonological mapping process, this forward-backward difference of occipital entrainment was not present for actually observed lip movements. Importantly, the respective occipital region received more top-down input, especially from left premotor, primary motor, and somatosensory regions and, to a lesser extent, also from posterior temporal cortex. Strikingly, across participants, the extent of top-down modulation of the visual cortex stemming from these regions partially correlated with the strength of entrainment to absent acoustic forward speech envelope, but not to present forward lip movements. Our findings demonstrate that a distributed cortical network, including key dorsal stream auditory regions [3-5], influences how the visual cortex shows sensitivity to the intelligibility of speech while tracking silent lip movements.


Assuntos
Percepção da Fala/fisiologia , Fala/fisiologia , Córtex Visual/fisiologia , Estimulação Acústica , Adulto , Córtex Auditivo/fisiologia , Mapeamento Encefálico , Feminino , Humanos , Lábio , Leitura Labial , Magnetoencefalografia/métodos , Masculino , Córtex Motor/fisiologia , Movimento , Fonética , Inteligibilidade da Fala/fisiologia
15.
Front Psychol ; 5: 1230, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25400608

RESUMO

In cognitive neuroscience, prerequisites of consciousness are of high interest. Within recent years it has become more commonly understood that ongoing brain activity, mainly measured with electrophysiology, can predict whether an upcoming stimulus is consciously perceived. One approach to investigate the relationship between ongoing brain activity and conscious perception is to conduct near-threshold (NT) experiments and focus on the pre-stimulus period. The current review will, in the first part, summarize main findings of pre-stimulus research from NT experiments, mainly focusing on the alpha band (8-14 Hz). It is probable that the most prominent finding is that local (mostly sensory) areas show enhanced excitatory states prior to detection of upcoming NT stimuli, as putatively reflected by decreased alpha band power. However, the view of a solely local excitability change seems to be too narrow. In a recent paper, using a somatosensory NT task, Weisz et al. (2014) replicated the common alpha finding and, furthermore, conceptually embedded this finding into a more global framework called "Windows to Consciousness" (Win2Con). In this review, we want to further elaborate on the crucial assumption of "open windows" to conscious perception, determined by pre-established pathways connecting sensory and higher order areas. Methodologically, connectivity and graph theoretical analyses are applied to source-imaging magnetoencephalographic data to uncover brain regions with strong network integration as well as their connection patterns. Sensory regions with stronger network integration will more likely distribute information when confronted with weak NT stimuli, favoring its subsequent conscious perception. First experimental evidence confirms our aforementioned "open window" hypothesis. We therefore emphasize that future research on prerequisites of consciousness needs to move on from investigating solely local excitability to a more global view of network connectivity.

16.
Dev Cogn Neurosci ; 5: 95-105, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23500669

RESUMO

Children with Asperger's syndrome show deficits in social functioning while their intellectual and language development is intact suggesting a specific dysfunction in mechanisms mediating social cognition. An action observation/execution matching system might be one such mechanism. Recent studies indeed showed that electrophysiological modulation of the "Mu-rhythm" in the 10-12Hz range is weaker when individuals with Asperger's syndrome observe actions performed by others compared to controls. However, electrophysiological studies typically fall short in revealing the neural generators of this activity. To fill this gap we assessed magnetoencephalographic Mu-modulations in Asperger's and typically developed children, while observing grasping movements. Mu-power increased at frontal and central sensors during movement observation. This modulation was stronger in typical than in Asperger children. Source localization revealed stronger sources in premotor cortex, the intraparietal lobule (IPL) and the mid-occipito-temporal gyrus (MOTG) and weaker sources in prefrontal cortex in typical participants compared to Asperger. Activity in premotor regions, IPL and MOTG correlated positively with social competence, whereas prefrontal Mu-sources correlated negatively with social competence. No correlation with intellectual ability was found at any of these sites. These findings localize abnormal Mu-activity in the brain of Asperger children providing evidence which associates motor-system abnormalities with social-function deficits.


Assuntos
Síndrome de Asperger/fisiopatologia , Magnetoencefalografia/métodos , Córtex Motor/fisiologia , Estimulação Luminosa/métodos , Comportamento Social , Adolescente , Síndrome de Asperger/diagnóstico , Criança , Feminino , Humanos , Masculino , Desempenho Psicomotor/fisiologia
17.
Soc Cogn Affect Neurosci ; 6(4): 450-9, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20601423

RESUMO

Subjective experience suggests that negatively arousing memories are harder to control than neutral ones. Here, we investigate this issue in an item-cued directed forgetting experiment. Electroencephalogram event-related potentials (ERPs) were recorded as participants viewed un-arousing neutral and highly arousing negative photographs, each followed by a cue to remember or forget it. Directed forgetting, that is reduced recognition of 'to-be-forgotten' items, occurred for neutral but not negative pictures. ERPs revealed three underlying effects: first, during picture viewing a late parietal positive potential (LPP) was more pronounced for negative than for neutral pictures. Second, 'remember' cues were associated with larger LPPs than 'forget' cues. Third, an enhanced frontal positivity appeared for 'forget' cues. This frontal positivity was generated in right dorso-lateral prefrontal regions following neutral pictures and in medial frontal cortex following negative pictures. LPP magnitude when viewing negative pictures was correlated with reduced directed forgetting, whereas both the enhanced frontal positivity for forget cues and the larger parietal positivity for remember cues predicted more directed forgetting. This study indicates that both processes of selective rehearsal (parietal positivities) and frontally controlled inhibition contribute to successful directed forgetting. However, due to their deeper incidental processing, highly arousing negative pictures are exempt from directed forgetting.


Assuntos
Emoções/fisiologia , Potenciais Evocados/fisiologia , Rememoração Mental/fisiologia , Adulto , Análise de Variância , Sinais (Psicologia) , Interpretação Estatística de Dados , Discriminação Psicológica/fisiologia , Eletroencefalografia , Feminino , Lobo Frontal/fisiologia , Humanos , Masculino , Lobo Parietal/fisiologia , Estimulação Luminosa , Desempenho Psicomotor/fisiologia , Reconhecimento Psicológico/fisiologia , Adulto Jovem
18.
Parasit Vectors ; 4: 206, 2011 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-22029536

RESUMO

BACKGROUND: Oncomelania hupensis robertsoni is the sole intermediate host for Schistosoma japonicum in western China. Given the close co-evolutionary relationships between snail host and parasite, there is interest in understanding the distribution of distinct snail phylogroups as well as regional population structures. Therefore, this study focuses on these aspects in a re-emergent schistosomiasis area known to harbour representatives of two phylogroups - the Deyang-Mianyang area in Sichuan Province, China. Based on a combination of mitochondrial and nuclear DNA, the following questions were addressed: 1) the phylogeography of the two O. h. robertsoni phylogroups, 2) regional and local population structure in space and time, and 3) patterns of local dispersal under different isolation-by-distance scenarios. RESULTS: The phylogenetic analyses confirmed the existence of two distinct phylogroups within O. h. robertsoni. In the study area, phylogroups appear to be separated by a mountain range. Local specimens belonging to the respective phylogroups form monophyletic clades, indicating a high degree of lineage endemicity. Molecular clock estimations reveal that local lineages are at least 0.69-1.58 million years (My) old and phylogeographical analyses demonstrate that local, watershed and regional effects contribute to population structure. For example, Analyses of Molecular Variances (AMOVAs) show that medium-scale watersheds are well reflected in population structures and Mantel tests indicate isolation-by-distance effects along waterways. CONCLUSIONS: The analyses revealed a deep, complex and hierarchical structure in O. h. robertsoni, likely reflecting a long and diverse evolutionary history. The findings have implications for understanding disease transmission. From a co-evolutionary standpoint, the divergence of the two phylogroups raises species level questions in O. h. robertsoni and also argues for future studies relative to the distinctness of the respective parasites. The endemicity of snail lineages at the regional level supports the concept of endemic schistosomiasis areas and calls for future geospatial analyses for a better understanding of respective boundaries. Finally, local snail dispersal mainly occurs along waterways and can be best described by using cost distance, thus potentially enabling a more precise modelling of snail, and therefore, parasite dispersal.


Assuntos
Biota , Gastrópodes/classificação , Gastrópodes/genética , Filogeografia , Animais , China , DNA/química , DNA/genética , Genótipo , Dados de Sequência Molecular , Análise de Sequência de DNA
19.
Brain Topogr ; 20(4): 192-204, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18335310

RESUMO

Recently studied 'old' stimuli lead to larger frontal and parietal ERP responses than 'new' stimuli. The present experiment investigated the neuromagnetic correlates (MEG) of this 'old-new' effect and its modulation by emotional stimulus content. Highly arousing pleasant, highly arousing unpleasant and un-arousing neutral photographs were presented to the participants with the instruction to memorize them. They were later re-presented together with new photographs in an old-new decision task. In line with previous ERP studies, a long-lasting old-new effect (350-700 ms) was found. Independently, an emotion effect also occurred, as reflected in a, particularly left temporal, activity increase for emotional pictures between 450 and 580 ms. Moreover, only for the pleasant pictures did the early part of the old-new effect, which is thought to reflect familiarity based recognition processes, interact with picture content: The old-new effect for pleasant pictures in frontal regions was larger than the one for neutral or unpleasant pictures between 350 and 450 ms. In parallel, subjects' responses were accelerated towards and biased in favour of classifying pleasant pictures as old. However, when false alarm rate was taken into account, there was no significant effect of emotional content on recognition accuracy. In sum, this MEG study demonstrates an effect of particularly pleasant emotional content on recognition memory which may be mediated by a familiarity based process.


Assuntos
Mapeamento Encefálico , Emoções/fisiologia , Potenciais Evocados Visuais/fisiologia , Magnetoencefalografia , Reconhecimento Visual de Modelos/fisiologia , Adulto , Análise de Variância , Discriminação Psicológica/fisiologia , Eletroencefalografia/métodos , Feminino , Humanos , Masculino , Estimulação Luminosa/métodos , Tempo de Reação/fisiologia , Fatores de Tempo
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