Detalhe da pesquisa
1.
Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency.
Bioorg Med Chem
; 104: 117693, 2024 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38552598
2.
Prodrug-Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment.
Chembiochem
; 24(24): e202300526, 2023 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37840006
3.
Influence of Aib-Containing Amphipathic Helical Chain Length in MAP(Aib)-cRGD as Carrier for siRNA Delivery.
Chem Biodivers
; 19(2): e202100728, 2022 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-34842340
4.
α-Aminoisobutyric Acid-Containing Amphipathic Helical Peptide-Cyclic RGD Conjugation as a Potential Drug Delivery System for MicroRNA Replacement Therapy in Vitro.
Mol Pharm
; 16(11): 4542-4550, 2019 11 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31596588
5.
Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer cells.
Bioorg Med Chem Lett
; 29(15): 1934-1937, 2019 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31133532
6.
Effective gene silencing activity of prodrug-type 2'-O-methyldithiomethyl siRNA compared with non-prodrug-type 2'-O-methyl siRNA.
Bioorg Med Chem Lett
; 28(12): 2171-2174, 2018 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29764744
7.
Syntheses of prodrug-type 2'-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2'-hydroxy oligonucleotides under reducing condition.
Bioorg Med Chem
; 26(22): 5838-5844, 2018 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30420326
8.
Syntheses of prodrug-type phosphotriester oligonucleotides responsive to intracellular reducing environment for improvement of cell membrane permeability and nuclease resistance.
Bioorg Med Chem Lett
; 27(14): 3135-3138, 2017 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28532670
9.
Structure-activity relationship study of Aib-containing amphipathic helical peptide-cyclic RGD conjugates as carriers for siRNA delivery.
Bioorg Med Chem Lett
; 27(24): 5378-5381, 2017 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29157863
10.
Gene silencing by 2'-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment.
Bioorg Med Chem Lett
; 26(3): 845-848, 2016 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26755395
11.
Design of cyclic RGD-conjugated Aib-containing amphipathic helical peptides for targeted delivery of small interfering RNA.
Bioorg Med Chem
; 24(18): 4478-4485, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27480031
12.
Synthesis of novel cationic spermine-conjugated phosphotriester oligonucleotide for improvement of cell membrane permeability.
Bioorg Med Chem Lett
; 25(17): 3610-5, 2015 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26149182
13.
Aib-containing peptide analogs: cellular uptake and utilization in oligonucleotide delivery.
Bioorg Med Chem
; 22(24): 6776-80, 2014 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25468041
14.
A New Nucleic Acid Prodrug Responsive to High Thiol Concentration: Synthesis of 2'-O-Methyldithiomethyl-Modified Oligonucleotides by Post-Synthetic Modification.
Curr Protoc Nucleic Acid Chem
; 62: 4.63.1-4.63.20, 2015 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26380903