Detalhe da pesquisa
1.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Cell
; 171(3): 696-709.e23, 2017 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-28965760
2.
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes.
Nat Chem Biol
; 17(2): 152-160, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33199914
3.
Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Proc Natl Acad Sci U S A
; 115(31): E7285-E7292, 2018 07 31.
Artigo
Inglês
| MEDLINE | ID: mdl-30012605
4.
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.
J Pharmacol Exp Ther
; 356(2): 410-23, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26645429
5.
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.
Nat Chem Biol
; 10(9): 760-767, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-25038787
6.
Expanding the ligandable proteome by paralog hopping with covalent probes.
bioRxiv
; 2024 Jan 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38293178
7.
Exploring aromatic chemical space with NEAT: novel and electronically equivalent aromatic template.
J Chem Inf Model
; 52(5): 1114-23, 2012 May 25.
Artigo
Inglês
| MEDLINE | ID: mdl-22486394
8.
A proteome-wide atlas of lysine-reactive chemistry.
Nat Chem
; 13(11): 1081-1092, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34504315
9.
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.
J Med Chem
; 63(22): 13561-13577, 2020 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32787094
10.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30113844
11.
Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.
ACS Chem Biol
; 12(8): 2040-2050, 2017 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-28636309
12.
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.
Cell Chem Biol
; 24(11): 1388-1400.e7, 2017 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28965727
13.
Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.
Nat Chem
; 13(11): 1151, 2021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34588639
14.
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
J Med Chem
; 59(3): 1165-75, 2016 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26734723
15.
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J Med Chem
; 58(1): 419-32, 2015 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25353650
16.
Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.
J Med Chem
; 57(23): 10072-9, 2014 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25375838
17.
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
ACS Med Chem Lett
; 3(3): 187-92, 2012 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24900455
18.
Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.
Bioorg Med Chem Lett
; 17(11): 3109-12, 2007 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17383873