Fluorescent antenna based on Förster resonance energy transfer (FRET) for optical wireless communications.

The use of fluorescent antennas in optical wireless communications (OWC) has been demonstrated previously, and it has been shown that it is an efficient method for enhancing receiver performance, providing both signal gain and a wide field of view (FoV). To achieve a high concentration gain at the receiver output, the selected fluorophores should have a high photoluminescence quantum yield (PLQY), limited overlap between their absorption and emission spectra, and emit light that can be efficiently detected. In addition, to support a high modulation bandwidth, the photoluminescence (PL) lifetime of the fluorophore needs to be short. In this paper, we propose a new fluorescent antenna architecture based on Förster resonance energy transfer (FRET). Our results show that, due to the photophysical interactions between the energy donor and energy acceptor, the use of FRET simultaneously increases PLQY and reduces PL lifetime. Additionally, employing FRET leads to an increased Stokes shift, ensuring that the emitted light has longer wavelengths, thus reducing self-absorption. This shift can also increase the efficiency with which the fluorescence is detected by a typical silicon (Si) photodetector. Consequently, our OWC results show that a new FRET-based antenna can achieve a significantly higher concentration gain and a wider transmission bandwidth than a conventional non-FRET antenna, leading to much higher data rates.

Dual-mode spatial index modulation for MIMO-OWC.

In this Letter, we propose and demonstrate a dual-mode spatial index modulation (DM-SIM) scheme for spectral efficiency enhancement of band-limited multiple-input multiple-output optical wireless communication (MIMO-OWC) systems. By performing dual-mode index modulation in the spatial domain, DM-SIM can transmit both spatial and constellation symbols. Since constellation design plays a vital role in the proposed DM-SIM scheme, we further propose three dual-mode constellation design approaches including phase rotation, amplitude scaling and joint phase rotation and amplitude scaling. Moreover, we also designed a differential log-likelihood ratio (LLR) detector for the proposed DM-SIM scheme. Experimental results show that the joint phase rotation and amplitude scaling approach can achieve a remarkable 3.2 dB signal-to-noise ratio (SNR) gain compared with the phase rotation approach in a 2×2 MIMO-OWC system applying DM-SIM.

Study of using different colors of fluorescent fibers as optical antennas in white LED based-visible light communications.

A fluorescent fiber can be used as an optical antenna in visible light communication (VLC) for simultaneous optical filtering and light concentration and therefore to build a compact receiver. Since its light concentration principle is based on fluorescence, it can exceed the étendue limit and achieve both a high concentration gain and a wide field-of-view (FOV). In addition, because the photoluminescence (PL) lifetime of the fluorophore is typically only several nanoseconds, it can support high-speed data transmissions. When a fluorescent fiber antenna is used in a white light-emitting diode (LED)-based VLC system, the transmission performance highly depends on how the absorption and emission spectra of the fluorophore are associated with both the spectrum of the LED and the responsivity of the silicon photodetector. In this paper, we analyze the performance of several different commercially available fluorescent fibers. We show that, when the data rate is low or the transmission distance is long, since the light emitted from a red fluorescent fiber is associated with high silicon responsivities, it can result in high signal-to-noise ratios (SNRs) at the receiver output and therefore lead to low transmission error rates. In contrast, when the data rate is high or the transmission distance is relatively short, the bandwidth dominates the overall performance and consequently the green fluorescent fiber has better performance since it only absorbs the light emitted from the blue LED rather than the light emitted from the yellow phosphor.

Capillary-based fluorescent antenna for visible light communications.

The use of fluorescent optical antennas in visible light communications (VLC) systems can enhance their performance by selectively absorbing light from the transmitter and concentrating the resulting fluorescence, whilst preserving a wide field of view. In this paper, we introduce a new and flexible way of creating fluorescent optical antennas. This new antenna structure is a glass capillary which is filled with a mixture of epoxy and a fluorophore before the epoxy is cured. Using this structure, an antenna can be easily and efficiently coupled to a typical photodiode. Consequently, the leakage of photons from the antenna can be significantly reduced when compared to previous antennas created using microscope slides. Moreover, the process of creating the antenna is simple enough for the performance of antennas containing different fluorophores to be compared. In particular, this flexibility has been used to compare VLC systems that incorporate optical antennas containing three different organic fluorescent materials, Coumarin 504 (Cm504), Coumarin 6 (Cm6), and 4-(Dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM), when a white light-emitting diode (LED) is used as the transmitter. Results show that, since it only absorbs light emitted from the gallium nitride (GaN) LED, a fluorophore that hasn't previously been used in a VLC system, Cm504, can result in a significantly higher modulation bandwidth. In addition, the bit error rate (BER) performance at different orthogonal frequency-division multiplexing (OFDM) data rates of antennas containing different fluorophores is reported. These experiments show for the first time that the best choice of fluorophore depends on the illuminance at the receiver. In particular, when the illuminance is low, the overall performance of the system is dominated by the signal-to-noise ratio (SNR). Under these conditions, the fluorophore with the highest signal gain is the best choice. In contrast, when the illuminance is high, the achievable data rate is determined by the bandwidth of the system and therefore the fluorophore that results in the highest bandwidth is the best choice.

Investigating the Underlying Mechanisms of Ardisia japonica Extract's Anti-Blood-Stasis Effect via Metabolomics and Network Pharmacology.

OBJECTIVE: Our study aims to assess Ardisia japonica (AJ)'s anti-blood-stasis effect and its underlying action mechanisms. METHODS: The primary components of AJ were determined using liquid chromatography-mass spectrometry (LC-MS). The blood stasis model was used to investigate the anti-blood-stasis effect of AJ extract. The underlying mechanisms of AJ against blood stasis were investigated via network pharmacology, molecular docking, and plasma non-targeted metabolomics. RESULTS: In total, 94 compounds were identified from an aqueous extract of AJ, including terpenoids, phenylpropanoids, alkaloids, and fatty acyl compounds. In rats with blood stasis, AJ reduced the area of stasis, decreased the inflammatory reaction in the liver and lungs of rats, lowered the plasma viscosity, increased the index of erythrocyte deformability, and decreased the index of erythrocyte aggregation, suggesting that AJ has an anti-blood-stasis effect. Different metabolites were identified via plasma untargeted metabolomics, and it was found that AJ exerts its anti-blood-stasis effect by reducing inflammatory responses through the cysteine and methionine metabolism, linolenic acid metabolism, and sphingolipid metabolism. For the effect of AJ on blood stasis syndrome, the main active ingredients predicted via network pharmacology include sinensetin, galanin, isorhamnetin, kaempferol, wogonin, quercetin, and bergenin, and their targets were TP53, HSP90AA1, VEGFA, AKT1, EGFR, and PIK3CA that were mainly enriched in the PI3K/AKT and MAPK signaling pathways, which modulate the inflammatory response. Molecular docking was also performed, and the binding energies of these seven compounds to six proteins were less than -5, indicating that the chemical components bind to the target proteins. CONCLUSIONS: This study suggests AJ effectively prevents blood stasis by reducing inflammation.

Communication Aspects of Visible Light Positioning (VLP) Systems Using a Quadrature Angular Diversity Aperture (QADA) Receiver.

Visible light positioning (VLP) is a promising indoor localization system in which light emitting diode (LED) luminaires are used as positioning beacons. Data communication is an essential aspect of any VLP system, as each luminaire must transmit information about its own location to the receiver. The quadrature angular diversity aperture (QADA) is a new receiver designed specifically for VLP systems using angle-of-arrival estimation. Previous QADA research has focused only on positioning and assumed error-free communication. In this paper, we investigate, via simulations and experiment, the actual communication characteristics of a VLP system that uses a QADA receiver. We calculate the signal-to-noise ratio and bit-error-rates for a range of scenarios and demonstrate the impact of the dimensions of the receiver. We show that reliable communication is assured in typical operating scenarios, proving that communication will not be a limiting factor when using QADA in VLP systems.

Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL-60, THP-1, and PC-3 Cell Lines.

Panaxadiol is a dammarane-type ginsenoside having high ginseng content. The 3-hydroxy group of panaxadiol (PD) was modified by fatty acids and diacids. The modified panax glycol had enhanced anticancer activity. Twelve PD derivatives were evaluated and purified by chemical synthesis, column chromatography, co-synthesis, and identification. The human leukemia cells THP-1, HL-60, and human prostate cancer cell lines PC-3 were evaluated; PD derivatives were tested and evaluated in vitro by MTT assay. The results showed that the antitumor activities of some derivatives on three tumor cell lines were better than those of PD.

Indoor Visible Light Positioning: Overcoming the Practical Limitations of the Quadrant Angular Diversity Aperture Receiver (QADA) by Using the Two-Stage QADA-Plus Receiver.

Visible light positioning (VLP), using LED luminaires as beacons, is a promising solution to the growing demand for accurate indoor positioning. In this paper, we introduce a two-stage receiver that has been specifically designed for VLP. This receiver exploits the advantages of two different VLP receiver types: photodiodes and imaging sensors. In this new receiver design a quadrant angular diversity aperture (QADA) receiver is combined with an off-the-shelf camera to form a robust new receiver called QADA-plus. Results are presented for QADA that show the impact of noise and luminaire geometry on angle of arrival estimation accuracy and positioning accuracy. Detailed discussions highlight other potential sources of error for the QADA receiver and explain how the two-stage QADA-plus can overcome these issues.

High angular resolution visible light positioning using a quadrant photodiode angular diversity aperture receiver (QADA).

The increasing use of white LEDs for indoor illumination provides a significant opportunity for Visible Light Positioning (VLP). The challenge is to design a small, unobtrusive sensor that can be incorporated into mobile devices to provide accurate measurements for triangulation. We present experimental results for a novel angle of arrival (AOA) detector that has been designed for use in a VLP system. The detector is composed of a transparent aperture in an opaque screen that is located above a quadrant photodiode (PD), separated by a known vertical distance. Light passing through the aperture from an LED casts a light spot onto the quadrant PD. The position of this spot, coupled with knowledge of the height of the aperture above the quadrant PD, provides sufficient information to determine both the incident and polar angles of the light. Experiments, using a prototype detector, show that detector is capable of accurate estimation of AOA. The root mean square errors (rMSE) were less than 0.11° for all the measured positions on the test bed, with 90% of positions having an rMSE of less than 0.07°.