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BACKGROUND: To explored the value of CT-measured body composition radiomics in preoperative evaluation of lymph node metastasis (LNM) in localized pancreatic ductal adenocarcinoma (LPDAC). METHODS: We retrospectively collected patients with LPDAC who underwent surgical resection from January 2016 to June 2022. According to whether there was LNM after operation, the patients were divided into LNM group and non-LNM group in both male and female patients. The patient's body composition was measured by CT images at the level of the L3 vertebral body before surgery, and the radiomics features of adipose tissue and muscle were extracted. Multivariate logistic regression (forward LR) analyses were used to determine the predictors of LNM from male and female patient, respectively. Sexual dimorphism prediction signature using adipose tissue radiomics features, muscle tissue radiomics features and combined signature of both were developed and compared. The model performance is evaluated on discrimination and validated through a leave-one-out cross-validation method. RESULTS: A total of 196 patients (mean age, 60 years ± 9 [SD]; 117 men) were enrolled, including 59 LNM in male and 36 LNM in female. Both male and female CT-measured body composition radiomics signatures have a certain predictive power on LNM of LPDAC. Among them, the female adipose tissue signature showed the highest performance (area under the ROC curve (AUC), 0.895), and leave one out cross validation (LOOCV) indicated that the signature could accurately classify 83.5% of cases; The prediction efficiency of the signature can be further improved after adding the muscle radiomics features (AUC, 0.924, and the accuracy of the LOOCV was 87.3%); The abilities of male adipose tissue and muscle tissue radiomics signatures in predicting LNM of LPDAC was similar, AUC was 0.735 and 0.773, respectively, and the accuracy of LOOCV was 62.4% and 68.4%, respectively. CONCLUSIONS: CT-measured body composition Radiomics strategy showed good performance for predicting LNM in LPDAC, and has sexual dimorphism. It may provide a reference for individual treatment of LPDAC and related research about body composition in the future.
RESUMO
Unconsolidated sandstone reservoirs have low rock strength and are easily damaged by sand production. To evaluate the effect of the microscopic pore system on the degree of recovery and sand production damage, five typical unconsolidated sandstone core samples were selected. The nuclear magnetic resonance T2 spectrum of the water-flooding experiments was used to analyze the oil displacement mechanism and sand production damage of the pore throat structure, and the control mechanism of the injection parameters was used to evaluate the recovery and sand production damage degree. The results showed that the recovery of the unconsolidated sandstone core samples was the highest when the injection volume was 6 PV, and the overall pore throat recovery increased from 14.37 to 48.72%. The recovery and sand production damage increased with increasing injection pressure. The overall pore throat recovery was the highest when the pressure was 20 MPa (48.42%), and the sand production damage index was the maximum when the pressure was 25 MPa (19.98%). Under a lower injection pressure, sand production damage mainly originates from loose sand. The main target of loose sand production damage is a smaller pore throat, and the sand production index increases slowly. The recovery increased with the pressure and increased relatively quickly. Under a higher injection pressure, sand production damage mainly comes from loose sand and skeleton sand, causing damage to both smaller and larger pore throats. The sand production damage is positively correlated with injection pressure. The recovery slows down with an increase in pressure or even decreases.