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INTRODUCTION: A growing number of randomized controlled trials (RCTs) have demonstrated the effectiveness of tumor necrosis factor-α (TNF-α) inhibitors in treating non-radiographic axial spondyloarthritis (nr-axSpA). This study aimed to evaluate the efficacy of TNF-α inhibitors in the treatment of nr-axSpA. METHODS: PubMed, EMBASE, Web of Science, and the Cochrane Library databases were systematically searched for relevant RCTs using specific keywords up to June 2023. The primary outcome was the proportion of patients who achieved Assessment in SpondyloArthritis international Society 40% (ASAS40). Secondary outcomes included ASAS20, Bath Ankylosing Spondylitis Disease Activity Index 50% (BASDAI50), ASAS partial remission, and ASAS5/6. RESULTS: A total of eight RCTs involving 1,376 patients were included. Patients receiving anti-TNF therapy exhibited a higher rate of ASAS40 (pooled RR = 2.36; 95% CI: 1.63-3.42; p < 0.001). In addition, the TNF-α inhibitor group showed higher BASDAI50 rates (pooled RR = 2.06; 95% CI: 1.48-2.89), ASAS20 rates (pooled RR = 1.48; 95% CI: 1.31-1.67), ASAS partial remission rates (pooled RR = 2.33; 95% CI: 1.58-3.43), and ASAS5/6 rates (RR = 3.46; 95% CI: 2.05-5.83) than the placebo group. CONCLUSION: The TNF-α inhibitors were effective in treating nr-axSpA.
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Ensaios Clínicos Controlados Aleatórios como Assunto , Fator de Necrose Tumoral alfa , Humanos , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Resultado do Tratamento , Espondilartrite/tratamento farmacológico , Antirreumáticos/uso terapêutico , Espondilite Anquilosante/tratamento farmacológicoRESUMO
Depth of field (DOF) and resolution are mutually restricted in integral imaging (II) display. To overcome the trade-offs, we propose an II display system that simultaneously enhances the DOF and resolution. The system consists of a transmissive mirror device (TMD), a semi-transparent mirror (STM), and two II display units. Each II display unit consists of a 4K display screen and a micro-lens array (MLA). Benefiting from the parallel placement of the TMD and the STM, two central depth planes are reconstructed, which effectively enhances the DOF. Meanwhile, the resolution in the overlapping DOF region is increased to two times due to the interpolation of the light field information from two II display units. The impact of the distance between the two II display units and the TMD on the 3D image quality is analyzed. In geometric optics, a distance between the II two display units and the TMD is optimized to eliminate ghost images. In wave optics, a distance is optimized to eliminate 3D pixel gaps by exploiting the diffraction effect of the TMD. Both the geometric and wave optics are considered simultaneously to obtain a high-quality 3D image without ghost images and 3D pixel gaps. A DOF and resolution-enhanced II display system is developed, and the experimental results verify its feasibility.
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In this paper, we propose an optofluidic lenticular lens array (OLLA) for a two-dimensional/three-dimensional (2D/3D) switchable display. The OLLA includes a bottom substrate layer with lenticular lens structure, a microfluidic layer with microchannels, and a top substrate layer with inlets as well as outlets. A micro gap is formed between the lenticular lens of the bottom substrate layer and the top substrate layer. When air is in the micro gap, the OLLA behaves as a lenticular lens array, which can realize 3D display. When fluid is filled in the micro gap, because the refractive index of the fluid is the same with the lenticular lens structure, the OLLA equivalents to a transparent flat panel, which can realize a 2D display. Experiments verify that a switchable 2D/3D display prototype based on this OLLA and a smartphone achieves both high-resolution 2D display and high-quality 3D display.
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An integral imaging-based 2D/3D convertible display system is proposed by using a lens-array holographic optical element (LAHOE), a polymer dispersed liquid crystal (PDLC) film, and a projector. The LAHOE is closely attached to the PDLC film to constitute a projection screen. The LAHOE is used to realize integral imaging 3D display. When the PDLC film with an applied voltage is in the transparent state, the projector projects a Bragg matched 3D image, and the display system works in 3D mode. When the PDLC film without an applied voltage is in the scattering state, the projector projects a 2D image, and the display system works in 2D mode. A prototype of the integral imaging-based 2D/3D convertible display is developed, and it provides 2D/3D convertible images properly.
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An augmented reality (AR) three-dimensional (3D) display based on one-dimensional integral imaging (1DII), by using a lenticular lens array holographic optical element (LLA-HOE), is proposed. The 3D image of the 1DII has higher vertical resolution compared with the image of conventional integral imaging whose resolution is sharply reduced for providing quasi-continuous viewpoints in both the horizontal and vertical directions. The proposed 3D display consists of a projector and an LLA-HOE and is compact. As an image combiner, the LLA-HOE can diffract Bragg-matched light rays that have the same wavelength and incident angle as the original reference wave; it can also function as a lenticular lens array to reconstruct a 3D image but transmit other light rays emitted from the surroundings. In the experiment, an LLA-HOE of 80 mm×80 mm size is recorded, and a combination of a high-resolution 3D virtual image and a real 3D object is presented by the proposed AR 3D display.
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In this paper, we propose a dual-view-zone tabletop 3D display system based on integral imaging by using a multiplexed holographic optical element (MHOE) that has the optical properties of two sets of microlens arrays. The MHOE is recorded by a reference beam using the single-exposure method. The reference beam records the wavefronts of a microlens array from two different directions. Thus, when the display beam is projected on the MHOE, two wavefronts with the different directions will be rebuilt and the 3D virtual images can be reconstructed in two viewing zones. The MHOE has angle and wavelength selectivity. Under the conditions of the matched wavelength and the angle of the display beam, the diffraction efficiency of the MHOE is greatest. Because the unmatched light just passes through the MHOE, the MHOE has the advantage of a see-through display. The experimental results confirm the feasibility of the dual-view-zone tabletop 3D display system.
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The adsorption behaviors of 1-naphthol, 1-naphthylamine and 1-naphthol/1-naphthylamine mixtures in water over two macroreticular adsorbents were investigated in single or binary batch systems at 293 K, 303 K and 313 K respectively. All the adsorption isotherms in the studied systems can be adequately fitted by Langmuir model. In the case of aminated macroreticular adsorbent NDA103, 1-naphthol is adsorbed to a larger extent than 1-naphthylamine; while, the opposite trend is found for nonpolar macroreticular adsorbent NDA100. It is noteworthy that at higher temperature (303 K and 313 K), the total uptake amounts of 1-naphthol and 1-naphthylamine in all binary-component systems are obvious larger than the pure uptake amounts in single-component systems, which is presumably due to the cooperative effect primarily arisen from the hydrogen-bonding interaction between the loaded 1-naphthol and 1-naphthylamine molecules. The simultaneous adsorption systems were confirmed to be helpful to the selective adsorption towards 1-naphthol according to the larger selective index.