Detalhe da pesquisa
1.
Broad-spectrum cyclic boronate ß-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
Bioorg Med Chem
; 62: 116722, 2022 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35358864
2.
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.
Nat Commun
; 13(1): 1625, 2022 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-35338128
3.
Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
Antimicrob Agents Chemother
; 55(8): 3854-60, 2011 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21628542
4.
Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid ß-Lactamase Inhibitor QPX7728.
J Med Chem
; 64(23): 17523-17529, 2021 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34817182
5.
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-ß-lactamases.
J Med Chem
; 63(14): 7491-7507, 2020 07 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32150407
6.
Cu-Catalyzed Decarboxylative Borylation.
ACS Catal
; 8(10): 9537-9542, 2018 Oct 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30505624
7.
Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.
J Med Chem
; 50(16): 3891-6, 2007 Aug 09.
Artigo
Inglês
| MEDLINE | ID: mdl-17636948
8.
Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted ß-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii.
J Med Chem
; 60(21): 8933-8944, 2017 11 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28994597
9.
Discovery of a Cyclic Boronic Acid ß-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J Med Chem
; 58(9): 3682-92, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-25782055
10.
Prodrugs of phosphates and phosphonates.
J Med Chem
; 51(8): 2328-45, 2008 Apr 24.
Artigo
Inglês
| MEDLINE | ID: mdl-18237108
11.
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.
ACS Med Chem Lett
; 1(9): 478-82, 2010 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24900234
12.
Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.
J Med Chem
; 51(22): 7075-93, 2008 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-18975928
13.
Synthesis of base-modified dihydropacidamycins.
Bioorg Med Chem Lett
; 12(7): 1121-3, 2002 Apr 08.
Artigo
Inglês
| MEDLINE | ID: mdl-11909731
14.
Prodrugs of cephalosporin RWJ-333441 (MC-04,546) with improved aqueous solubility.
Antimicrob Agents Chemother
; 47(6): 2043-6, 2003 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-12760896
15.
Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.
Bioorg Med Chem Lett
; 13(19): 3305-9, 2003 Oct 06.
Artigo
Inglês
| MEDLINE | ID: mdl-12951115