Detalhe da pesquisa
1.
A-series agent A-234: initial in vitro and in vivo characterization.
Arch Toxicol
; 98(4): 1135-1149, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38446233
2.
A-agents, misleadingly known as "Novichoks": a narrative review.
Arch Toxicol
; 97(10): 2587-2607, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37612377
3.
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease.
Int J Mol Sci
; 24(11)2023 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37298087
4.
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Bioorg Med Chem Lett
; 43: 128100, 2021 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33984470
5.
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimers drugs dealing with cholinergic, amyloid and mitochondrial systems.
Bioorg Chem
; 107: 104596, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33421953
6.
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.
Arch Toxicol
; 95(3): 985-1001, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33517499
7.
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats.
Drug Chem Toxicol
; 44(2): 207-214, 2021 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-31257938
8.
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators.
J Enzyme Inhib Med Chem
; 35(1): 478-488, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31910701
9.
Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators.
Toxicol Appl Pharmacol
; 383: 114776, 2019 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31629733
10.
Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods.
Molecules
; 23(11)2018 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30423961
11.
Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication.
Chem Biol Interact
; 394: 110941, 2024 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38493910
12.
Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870.
Food Chem Toxicol
; 167: 113236, 2022 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-35738326
13.
Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides.
Toxicol In Vitro
; 85: 105463, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-36041654
14.
A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats.
Acta Medica (Hradec Kralove)
; 64(3): 145-152, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34779379
15.
Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease.
Future Med Chem
; 13(9): 785-804, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33829876
16.
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.
Biochem Pharmacol
; 186: 114460, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33571502
17.
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease.
ACS Chem Neurosci
; 12(9): 1698-1715, 2021 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33852284
18.
(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3ß Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease.
ACS Chem Neurosci
; 12(8): 1328-1342, 2021 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-33797877
19.
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors.
ACS Med Chem Lett
; 11(1): 65-71, 2020 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31938465
20.
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.
Eur J Med Chem
; 203: 112593, 2020 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32688201