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1.
Am J Med Genet A ; 191(7): 1693-1703, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37009761

RESUMO

Arthrogryposis multiplex congenita (AMC) is defined as "a group of congenital conditions characterized by joint contractures in two or more body areas." Given its heterogeneity, the definition of AMC has changed multiple times. This scoping review provides an overview of how AMC is defined in scientific publications, on existing knowledge and trends regarding the concept of AMC. Our review illuminates possible knowledge gaps and provides directions for future research. A scoping review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. Quantitative studies on AMC from 1995 to date were included. We summarized information about definitions/descriptions of AMC, study objectives, study designs, methods, funding, and involvement of patient organizations. A total of 2729 references were screened, and 141 articles fulfilled our inclusion criteria. Our scoping revealed that the majority of publications were cross-sectional or retrospective studies of children and young people, commonly about orthopedic management. Explicit or good definitions of AMC were provided in 86% of the cases. Recent publications on AMC mostly used consensus-based definitions. The research gaps were primarily related to adults, aging, etiology, and new medical treatment, in addition to implications on daily life.


Assuntos
Anormalidades Múltiplas , Artrogripose , Adolescente , Adulto , Criança , Humanos , Artrogripose/diagnóstico , Artrogripose/genética , Lacunas de Evidências , Estudos Retrospectivos
2.
Tidsskr Nor Laegeforen ; 142(1)2023 01 17.
Artigo em Inglês, Norueguês | MEDLINE | ID: mdl-36655972

RESUMO

Neuropathy can have many causes, some less well known than others. In this article, we present the case of a young man with progressive neurological deficit over several months. The cause was found to be an increasing social problem.


Assuntos
Hipestesia , Perna (Membro) , Masculino , Humanos , Hipestesia/etiologia
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