Detalhe da pesquisa
1.
Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations.
Stroke
; 54(10): 2698-2707, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37694403
2.
Defining a Target Population to Effectively Test a Neuroprotective Drug.
Stroke
; 52(2): 505-510, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33423513
3.
Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance.
Stroke
; 50(11): 3228-3237, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31526124
4.
TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models.
Mol Ther
; 26(8): 2047-2059, 2018 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29910175
5.
Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke.
Stroke
; 47(1): 206-13, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26628388
6.
Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia.
J Neuroinflammation
; 12: 87, 2015 May 10.
Artigo
Inglês
| MEDLINE | ID: mdl-25958332
7.
Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia.
FASEB J
; 28(11): 4710-8, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25063846
8.
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis.
Br J Pharmacol
; 2024 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38742374
9.
eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells.
Biochim Biophys Acta
; 1823(2): 430-8, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22178387
10.
Silent information regulator 1 protects the brain against cerebral ischemic damage.
Stroke
; 44(8): 2333-7, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23723308
11.
Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.
J Neurochem
; 126(6): 819-26, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23600725
12.
Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice.
Front Cell Neurosci
; 17: 1219847, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37636586
13.
APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.
Front Neurol
; 14: 1127585, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36908619
14.
Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.
Biomed Pharmacother
; 158: 114214, 2023 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-36916435
15.
Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial.
JAMA Neurol
; 80(8): 779-788, 2023 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37338893
16.
Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.
Stroke
; 43(6): 1647-53, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22426312
17.
First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers.
Mol Ther Nucleic Acids
; 28: 124-135, 2022 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35402075
18.
New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress.
J Biol Chem
; 285(45): 34355-63, 2010 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-20736160
19.
Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI.
J Cereb Blood Flow Metab
; 41(7): 1692-1706, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34152893
20.
Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction.
Biomolecules
; 10(8)2020 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32784904