Detalhe da pesquisa
1.
P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice.
Pharm Res
; 40(8): 1885-1899, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37344602
2.
Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry.
Anal Bioanal Chem
; 411(20): 5331-5345, 2019 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-31209549
3.
Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism.
Acta Pharm Sin B
; 13(2): 618-631, 2023 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-36873183
4.
Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.
Biomed Pharmacother
; 164: 114956, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37267638
5.
Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.
Int J Cancer
; 130(1): 223-33, 2012 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21351087
6.
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.
Clin Cancer Res
; 15(7): 2344-51, 2009 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19276246
7.
Bottom-up sample preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices.
Bioanalysis
; 12(19): 1405-1425, 2020 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-32975434
8.
Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 865(1-2): 55-62, 2008 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18325856
9.
Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer.
Cancer Chemother Pharmacol
; 59(6): 825-37, 2007 May.
Artigo
Inglês
| MEDLINE | ID: mdl-16988825
10.
Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours.
Radiother Oncol
; 80(2): 207-13, 2006 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-16914220
11.
Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry.
J Mass Spectrom
; 41(10): 1268-76, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16981212
12.
Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients.
Basic Clin Pharmacol Toxicol
; 98(1): 86-96, 2006 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-16433897
13.
Screening for illicit heroin use in patients in a heroin-assisted treatment program.
J Anal Toxicol
; 30(6): 390-4, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16872571
14.
Analysis of diacetylmorphine, caffeine, and degradation products after volatilization of pharmaceutical heroin for inhalation.
J Anal Toxicol
; 30(1): 6-13, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16620525
15.
Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar.
J Pharm Anal
; 6(4): 268-275, 2016 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-29403992
16.
Metabolism of docetaxel in mice.
Cancer Chemother Pharmacol
; 56(3): 299-306, 2005 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15864592
17.
Pharmacokinetic comparison of two methods of heroin smoking: 'chasing the dragon' versus the use of a heating device.
Eur Neuropsychopharmacol
; 15(3): 263-9, 2005 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15820414
18.
The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 824(1-2): 213-21, 2005 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-16103023
19.
LC-UV method development and validation for the investigational anticancer agent imexon and identification of its degradation products.
J Pharm Biomed Anal
; 38(4): 686-94, 2005 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15967296
20.
Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form.
J Pharm Biomed Anal
; 39(1-2): 46-53, 2005 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15899571