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1.
Kyobu Geka ; 75(8): 602-605, 2022 Aug.
Artigo em Japonês | MEDLINE | ID: mdl-35892299

RESUMO

A 57-year-old man presented to our hospital with multiple rib fractures and pleural effusion caused by a traffic accident. We inserted a chest tube and diagnosed him with hemothorax. We performed damage control surgery with right thoracotomy in the emergency room to confirm the bleeding point. The main sources of bleeding were multiple rib fractures and lung injury. We performed partial lung resection and gauze packing into the thoracic cavity and confirmed the stability of the patient's hemodynamics. The next day, we performed a second-look operation at which we fixed the rib fractures and confirmed hemostasis. When fixing the ribs, we used a bioabsorbable plate instead of a metal plate. It has been reported that bioabsorbable plates are less susceptible to infection than metal plates. After the operation, the patient's respiratory condition stabilized, and no signs of infection were noted. In our experience, rib fixation using absorbent plates is useful in surgery that requires attention to infection.


Assuntos
Tórax Fundido , Fraturas das Costelas , Implantes Absorvíveis , Placas Ósseas/efeitos adversos , Tórax Fundido/diagnóstico por imagem , Tórax Fundido/etiologia , Tórax Fundido/cirurgia , Fixação Interna de Fraturas/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Fraturas das Costelas/diagnóstico por imagem , Fraturas das Costelas/cirurgia
2.
Kyobu Geka ; 75(3): 182-184, 2022 Mar.
Artigo em Japonês | MEDLINE | ID: mdl-35249949

RESUMO

An 85-year-old man was admitted to our hospital because of an abnormal shadow on chest X-ray. Chest and abdominal computed tomography (CT) revealed abdominal aortic aneurysm (AAA) in addition to a mass in the right lower lobe. Since both the AAA and lung mass needed surgical treatment, we performed endovascular aortic repair (EVAR) for the AAA, followed by right lower lobectomy 26 days after the surgery for AAA. There were no complications following either operation, and the patient left the hospital on the 10th day after pulmonary resection.


Assuntos
Aneurisma da Aorta Abdominal , Implante de Prótese Vascular , Procedimentos Endovasculares , Neoplasias Pulmonares , Idoso de 80 Anos ou mais , Aneurisma da Aorta Abdominal/complicações , Aneurisma da Aorta Abdominal/diagnóstico por imagem , Aneurisma da Aorta Abdominal/cirurgia , Implante de Prótese Vascular/métodos , Procedimentos Endovasculares/métodos , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Masculino , Estudos Retrospectivos , Resultado do Tratamento
3.
Surg Today ; 44(1): 123-30, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23420096

RESUMO

PURPOSE: Chemoradiation therapy (CRT) is recommended as standard care for stage III non-small cell lung cancer (NSCLC), but some patients experience local recurrence after the treatment. Surgical resection after CRT involves high surgical risk, but is expected to increase the curability. This study was performed to investigate the impact of presurgical CRT on the postoperative outcome, focusing especially on the effect of radiation therapy. METHODS: Twenty-six patients with stage III (N2 or T3-4) NSCLC underwent pulmonary resection after CRT. A radiation dose up to 40-70 Gy was given with concurrent chemotherapy. The morbidity, mortality and survival after surgical resection were examined. RESULTS: Lung resection was performed as lobectomy (73 %) or pneumonectomy (19 %). Postoperative complications occurred in 12 patients (morbidity 46.1 %). The overall 5-year survival of the entire cohort was 69.7 %. The factors associated with favorable long-term survival included a pathological complete response (CR) and mediastinal node negative condition after CRT, and microscopic complete resection. CONCLUSION: Surgical resection for stage III patients after CRT may provide a survival benefit with acceptable morbidity. The surgical morbidity may be increased by prior radiation therapy, thus, surgeons should be familiar with the available countermeasures to reduce the surgical risk.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/terapia , Quimiorradioterapia Adjuvante , Neoplasias Pulmonares/terapia , Pneumonectomia , Cuidados Pré-Operatórios , Adulto , Idoso , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Carcinoma Pulmonar de Células não Pequenas/mortalidade , Carcinoma Pulmonar de Células não Pequenas/patologia , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Pneumonectomia/mortalidade , Tomografia por Emissão de Pósitrons , Estudos Prospectivos , Taxa de Sobrevida , Tomografia Computadorizada por Raios X , Resultado do Tratamento
4.
Kyobu Geka ; 67(1): 44-7, 2014 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-24743412

RESUMO

When reconstructing the radionecrotic chest wall ulcer, safety of the flap is essential. If the flap becomes necrotic, fatal situations may arise, such as pyothorax, especially when prosthetic replacement is chosen. Thus, flaps with a rich and stable blood supply must be chosen for necrotic chest wall reconstruction.We present the case of a 67-year-old lady who developed radionecrosis following irradiation of the chest wall after radical mastectomy. The ensuing radionecrosis of the skin and chest wall progressed to advanced ischemia with secondary infection. The necrotic ribs and surrounding tissue were debrided and the anterior chest wall was reconstructed by pediculed omental and vertical rectus abdominis myocutaneous flap. The patient is currently well and alive without any evidence of recurrence of either infection or breast carcinoma.


Assuntos
Lesões por Radiação/cirurgia , Parede Torácica/patologia , Toracoplastia/métodos , Úlcera/cirurgia , Idoso , Autoenxertos , Neoplasias da Mama/radioterapia , Feminino , Humanos , Parede Torácica/efeitos da radiação
5.
Jpn J Antibiot ; 66(1): 37-43, 2013 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-23777015

RESUMO

We report a case of pulmonary aspergillosis in lung transplant recipient who was successfully treated with inhalation administration of anti-fungal agent. The case was 33-year-old female. Two years ago, she had received lung transplant because of lymphangioleiomyomatosis. One year ago, she had diagnosed of pulmonary aspergillosis and successfully treated with micafungin and itraconazole. Then she had been continuous administered with itraconazole. In June 20xx, she had nausea and vomiting and was diagnosed of viral enteritis. Although abdominal symptoms were relieved, ground glass opacity was discovered in her right lung. Bronchoscopic examination revealed ulceration of bronchus with white necrotic substance. Laboratory culture test demonstrated Aspergillus spp. Finally she was diagnosed of recurrent pulmonary aspergillosis. First, she was treated with intravascular administration of micafungin. Then, inhalation administration of liposomal amphotericin B was changed. Ground glass opacity and bronchial region of pulmonary aspergillosis was improved. Thereafter, inhalation of amphotericin B was continued and no recurrence of pulmonary aspergillosis has been found. Inhalation of anti-fungal agent could be an option for pulmonary aspergillosis.


Assuntos
Anfotericina B/administração & dosagem , Antifúngicos/administração & dosagem , Transplante de Pulmão/efeitos adversos , Aspergilose Pulmonar/tratamento farmacológico , Administração por Inalação , Adulto , Feminino , Humanos
6.
Anticancer Res ; 43(8): 3659-3664, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37500163

RESUMO

BACKGROUND/AIM: The indications for limited resection in high-risk patients with stage I non-small cell lung cancer (NSCLC) remain controversial. The purpose of this study was to evaluate the prognostic impact of the preoperative prognostic nutritional index (PNI) in high-risk patients undergoing limited resection. PATIENTS AND METHODS: High-risk patients undergoing limited resection for stage I NSCLC in our institution from 2005 to 2020 were retrospectively reviewed. Patients with clinical/pathological Tis/minimally invasive adenocarcinoma and multiple NSCLC were excluded. A multivariate Cox regression analysis was conducted to identify factors associated with overall survival (OS). RESULTS: Ninety eligible patients were included in this study. Grade ≥2 postoperative complications were significantly more frequent in the low-PNI group (6 cases, 16.6% vs. 7 cases, 12.9%; p=0.03). The rate of death due to other diseases was significantly higher in the low-PNI group than in the high-PNI group (14 cases, 50.0% vs. 11 cases, 25.0%; p=0.002). The multivariate analysis showed that male sex, Brinkman index ≥400, preoperative low PNI and pathological T factor ≥T1c/T2a were independent prognostic factors for OS. CONCLUSION: In high-risk patients undergoing limited resection for stage I NSCLC, low PNI was a poor prognostic factor, especially in relation to death from other diseases and lung cancer. The results may support thoracic surgeons in decision-making in relation to the indications for surgery.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Humanos , Masculino , Carcinoma Pulmonar de Células não Pequenas/patologia , Avaliação Nutricional , Neoplasias Pulmonares/patologia , Prognóstico , Estudos Retrospectivos , Estado Nutricional
7.
Respir Investig ; 61(6): 698-701, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37708635

RESUMO

A patient with sarcoidosis was found to have a massive left pleural effusion. Her chest computed tomography showed small nodules in the lung parenchyma and swelling of the hilar lymph nodes, with normal visceral and parietal pleura. Thoracoscopy showed white nodules on the visceral pleura and normal parietal pleura, which were resected. Epithelioid granulomas were seen in the visceral pleura and lung parenchyma. Surprisingly, in the parietal pleura, abnormal cells that were positive for the leukocyte common antigen, CD20, and CD79a were found, leading to the diagnosis of malignant B-cell lymphoma.


Assuntos
Linfoma , Derrame Pleural , Neoplasias Pleurais , Sarcoidose , Feminino , Humanos , Pleura/diagnóstico por imagem , Neoplasias Pleurais/complicações , Neoplasias Pleurais/diagnóstico por imagem , Sarcoidose/complicações , Sarcoidose/diagnóstico por imagem , Linfoma/patologia
8.
Tumour Biol ; 33(6): 2365-70, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23001907

RESUMO

The human epididymis 4 (HE4) protein is expressed in the epididymis and respiratory tract. We previously reported that HE4 is also expressed in pulmonary adenocarcinoma. The purpose of this study was to investigate serum levels of HE4 as a biological marker in pulmonary adenocarcinoma. As the trained set, 102 patients with pulmonary adenocarcinoma who underwent surgery in our institute from 2008 to 2011 were evaluated. They were compared with 58 healthy controls and 16 cases of benign lung disease. In the validation, we used 104 patients with pulmonary adenocarcinoma operated on between 2000 and 2007. Postoperative changes of serum HE4 levels were investigated in 35 patients. The level of HE4 was determined by enzyme immunometric assay and compared with clinicopathological factors. In the trained set, HE4 levels in sera in pulmonary adenocarcinoma were significantly higher than in healthy controls and benign lung disease. Receiver operating characteristic curve showed that HE4 was a good discriminator of pulmonary adenocarcinoma (cut-off point, 50.3 pM; area under curve, 0.825; 95 % confidence interval, 0.76-0.89, p < 0.001). In the validation set, serum HE4 levels were significantly correlated with age, nodal status, and carcinoembryonic antigen. Furthermore, postoperative increase of HE4 serum levels showed a significant correlation with recurrence (p = 0.032). The 5-year overall survival rate was 52.6 % in the HE4-positive group compared with 97.1 % in the HE4-negative group (p = 0.001). These data showed that HE4 expression in sera is associated with progression of pulmonary adenocarcinoma and a possible biomarker.


Assuntos
Adenocarcinoma/sangue , Biomarcadores Tumorais/sangue , Neoplasias Pulmonares/sangue , Proteínas/metabolismo , Adenocarcinoma/mortalidade , Adenocarcinoma/patologia , Idoso , Antígeno Ca-125/sangue , Estudos de Casos e Controles , Progressão da Doença , Ensaio de Imunoadsorção Enzimática , Feminino , Seguimentos , Humanos , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/patologia , Masculino , Estadiamento de Neoplasias , Prognóstico , Curva ROC , Taxa de Sobrevida , Proteína 2 do Domínio Central WAP de Quatro Dissulfetos
9.
Kyobu Geka ; 65(1): 25-8, 2012 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-22314153

RESUMO

Recently, the greater utilization of computed tomography (CT) has led to an increasing proportion of small-sized stage I A lung cancer in less than 1 cm in diameter. However, a treatment strategy for these small-sized lung cancers has not yet been defined. The aim of this study was to investigate surgical outcomes regarding these lung cancers. A total of 123 patients who underwent complete surgical resection for lung cancer in less than 1 cm between January 1995 and March 2010 were retrospectively evaluated. The 123 study subjects consisted of 54 male and 69 female patients. The mean age was 64.0 (43~82) years. The mean tumor size was 0.9( 0.3~1.0) cm. In this study, 70 patients underwent lobectomy (56.9%). Segmentectomy and wedge resection were underwent 23( 18.7%) and 30 patients( 24.4%), respectively. The 3-, 5- and 10-year survival rates were 95.7, 92.3 and 85.7%, respectively, after the operation for lung cancer in less than 1 cm. There were no significant difference between sublobar resection and lobectomy. However, 2 patients( 1.6%) had recurrent cancer and 7 patients (5.7%) had lymph node metastasis. We suggested surgical procedure for patients with lung cancers in less than 1 cm should be selected with the greatest care, because recurrent cancer and lymph node metastasis can occur in patients.


Assuntos
Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Pneumonectomia/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
10.
Surg Today ; 41(9): 1302-5, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21874436

RESUMO

Bronchial complications owing to airway anastomosis still remain a cause of morbidity and mortality following lung transplantation, and bronchial stenosis is the most common manifestation. Current treatment strategies include endoscopic balloon dilation, laser ablation, and stent insertion. Although a variety of stent types are currently available, it is unclear as to which type of prosthesis is most suitable for post-transplant bronchial complications with regard to the primary effects and long-term outcomes. We herein discuss a case of stenosis of the right bronchial anastomosis in a patient who underwent right single lung transplantation for idiopathic pulmonary fibrosis. This complication was successfully treated with the placement of a modified Dumon Y-stent. The stent was removed 2 months after insertion, and the patient has subsequently maintained an adequate airway caliber. Computed tomography, especially the sagittal section through the chest, is useful for detecting bronchial stenosis and monitoring the healing of this condition.


Assuntos
Brônquios/cirurgia , Broncopatias/terapia , Transplante de Pulmão , Complicações Pós-Operatórias/terapia , Stents , Anastomose Cirúrgica , Brônquios/patologia , Broncopatias/diagnóstico por imagem , Broncopatias/etiologia , Broncografia , Constrição Patológica/diagnóstico por imagem , Constrição Patológica/terapia , Dilatação , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico por imagem
11.
Surg Today ; 41(4): 490-5, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21431480

RESUMO

PURPOSE: Tracheal surgery is an established treatment for various diseases; however, it is still a potentially challenging procedure. We herein discuss the safety of this procedure with regard to the coordination with airway interventional and anesthetic support. METHODS: A tracheal resection was performed on 18 patients. The dyspnea due to pre-existing severe airway stenosis, which was considered to be a risk factor for the safe induction of general anesthesia, was present in 12 (66.7%) cases. RESULTS: Seven of the 12 patients with pre-existing airway obstruction required interventional airway treatment before surgery. One case with a polyp-like tracheal tumor required venoarterial percutaneous cardiopulmonary support to establish adequate oxygenation before surgery. All 18 cases underwent a segmental resection of the trachea, with the average length of 3.6 rings. Postoperative recovery was uneventful for all but one patient with postintubation tracheal stenosis, who died 17 days after surgery due to a methicillin-resistant Staphylococcus aureus infection. Complications in the other patients included four cases of laryngeal nerve palsy, three of aspiration, and one patient with Horner syndrome, with a total morbidity of 27.7%. CONCLUSIONS: A tracheal resection is currently a safe procedure; however, cooperation with sophisticated airway interventional treatment teams, cardiopulmonary bypass support, or a well-trained anesthesiologist is essential for obtaining a successful outcome, especially for the cases with pre-existing severe airway obstruction.


Assuntos
Doenças da Traqueia/cirurgia , Adolescente , Adulto , Idoso , Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/cirurgia , Anestesia/métodos , Biópsia , Ponte Cardiopulmonar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Fatores de Risco , Análise de Sobrevida , Doenças da Traqueia/complicações , Neoplasias da Traqueia/complicações , Neoplasias da Traqueia/cirurgia , Resultado do Tratamento
12.
Respir Med Case Rep ; 33: 101430, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34401274

RESUMO

A 37-year-old man with fever, cough, and dyspnea with no medical history developed an eosinophilic pleural effusion and blood eosinophilia. No evidence of malignancy or pathogens was detected in the pleural effusion, and the pleural specimen obtained by thoracoscopy showed eosinophilic infiltration with inflammatory granulation tissue without fibrinoid necrosis or malignant cells. Since a myeloproliferative disorder was also excluded, the diagnosis was idiopathic eosinophilic pleurisy. Corticosteroid treatment was started and then slowly tapered, and the eosinophilic pleural effusion resolved. Considering the various etiologies of eosinophilic pleurisy, a practical clinical approach to the investigation and diagnosis of eosinophilic pleurisy is presented.

13.
Gen Thorac Cardiovasc Surg ; 69(2): 375-378, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32930959

RESUMO

Left-unilateral single-lobe lung transplantation from a living donor was performed in a 4-year-old boy who suffered from severe respiratory failure caused by bronchiolitis obliterans (BO) as a result of graft versus host disease (GVHD) after peripheral blood stem cell transplantation (PBSCT). The patient grew well during his early childhood years, with an excellent lung allograft function. However, severe thoracic scoliosis occurred 7 years after lung transplantation, which ultimately resulted in compression of the lung allograft followed by severe respiratory dysfunction, and the patient became dependent on mechanical ventilation support. Posterior spinal fusion of Th2-L3 with instrumentation and bone grafting was performed to correct scoliosis in the hope of recovering his thoracic capacity. The left thoracic volume was dramatically improved immediately after spinal fusion surgery, and the patient was ultimately weaned off of mechanical ventilation after a year of pulmonary rehabilitation.


Assuntos
Bronquiolite Obliterante , Transplante de Pulmão , Escoliose , Fusão Vertebral , Aloenxertos , Bronquiolite Obliterante/etiologia , Criança , Pré-Escolar , Humanos , Transplante de Pulmão/efeitos adversos , Masculino , Escoliose/cirurgia , Fusão Vertebral/efeitos adversos , Resultado do Tratamento
14.
Gen Thorac Cardiovasc Surg ; 68(4): 411-413, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31531836

RESUMO

We describe a unique technique for pulmonary artery reconstruction using a bovine pericardial conduit after long-segment sleeve resection of the pulmonary artery. In this technique, the conduit tube was not created in advance but was sewn in situ from a bovine pericardial "sheet" step-by-step to form a desirable diameter, length and curve to fit the vascular defect. This is a safe and secure method to create desirable conduit for long and complex pulmonary artery replacement.


Assuntos
Procedimentos de Cirurgia Plástica/métodos , Artéria Pulmonar/cirurgia , Técnicas de Sutura , Transplante Heterólogo/métodos , Procedimentos Cirúrgicos Vasculares/métodos , Adenocarcinoma/cirurgia , Idoso , Anastomose Cirúrgica/métodos , Animais , Bioprótese , Bovinos , Humanos , Neoplasias Pulmonares/cirurgia , Metástase Linfática , Masculino , Pericárdio/cirurgia , Procedimentos de Cirurgia Plástica/instrumentação , Suturas , Transplante Heterólogo/instrumentação , Resultado do Tratamento , Procedimentos Cirúrgicos Vasculares/instrumentação
16.
Anticancer Res ; 37(4): 1923-1929, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28373461

RESUMO

AIM: We investigated the possibility of BMI-1 and MEL-18 to predict survival in patients with pulmonary squamous cell carcinoma. MATERIALS AND METHODS: One hundred and ninety-nine patients underwent surgery in our Institute between 1995 and 2005. We used immunohistochemical (IHC) analysis to determine the expressions of BMI-1 and MEL-18 and compared them with clinicopathological factors and survival. RESULTS: Forty-one of 199 cases (21%) were BMI-1-positive. No correlation was found between BMI-1 and MEL-18 expression by IHC and clinicopathological factors. Five-year overall survival in the BMI-1-positive group (66.8%), but not MEL-18, was significantly better than that in the negative group (45.5%, p=0.04). In multivariate analysis, positive BMI-1 was a better prognostic factor of overall survival (hazard ratio (HR)=0.561, 95% confidence interval (CI)=0.271-1.16, p=0.12). CONCLUSION: BMI-1 expression, but not MEL-18, is associated with a favorable prognosis and is a possible prognostic factor of pulmonary squamous cell carcinoma.


Assuntos
Biomarcadores Tumorais/metabolismo , Carcinoma de Células Escamosas/secundário , Neoplasias Pulmonares/patologia , Proteína Quinase 7 Ativada por Mitógeno/metabolismo , Complexo Repressor Polycomb 1/metabolismo , Idoso , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/terapia , Terapia Combinada , Feminino , Humanos , Técnicas Imunoenzimáticas , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/terapia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
17.
Int Surg ; 91(1): 44-51, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16706103

RESUMO

The role of video-assisted thoracic surgery (VATS) thymectomy is still being studied, and many surgeons remain skeptical of the value of this recent option. We made a retrospective evaluation to ascertain whether VATS-extended thymectomy is as reliable as standard median sternotomy in the treatment of myasthenia gravis (MG) and whether the endoscopic procedure presents any advantages for patients. Eighteen consecutive patients requiring extended thymectomy for MG were treated between April 1997 and September 2003 at our hospital. Nine patients received VATS-extended thymectomy, and the remaining nine patients received standard extended thymectomy by sternotomy. In the VATS group, the anterior mediastinal space was well visualized by sternal lifting. The mean operative time was 268.3 +/- 51.1 minutes in the VATS group and 177.3 +/- 92.5 minutes in the sternotomy group. Operative time was significant longer in the VATS group than in the sternotomy group (P < 0.05). The mean operative bleeding was 68.6 +/- 47.8 ml in the VATS group and 154.1 +/- 109.0 ml in the sternotomy group. Operative bleeding was significantly less in the VATS group than in the sternotomy group (P < 0.05). There was no significant difference between the two groups with regard to postoperative duration of chest tube or the level of serum C-reactive protein on the first operative day. There was a downward trend in nicotinic acetylcholine receptors antibody levels after thymectomy compared with before thymectomy in both groups. VATS thymectomy should be considered a valid alternative to the established approaches aimed at achieving a "curative thymectomy" in patients with MG.


Assuntos
Miastenia Gravis/cirurgia , Esterno/cirurgia , Cirurgia Torácica Vídeoassistida , Toracoscopia , Timectomia/métodos , Adolescente , Adulto , Idoso , Anticorpos/análise , Proteína C-Reativa/análise , Tubos Torácicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prednisolona/administração & dosagem , Receptores Colinérgicos/imunologia , Estudos Retrospectivos
18.
Int Surg ; 88(3): 169-74, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14584774

RESUMO

Because elderly breast cancer patients differ in various biological characteristics from younger patients, it is important to clarify the clinical characteristics and treatment results of elderly patients with this disease. A total of 332 breast cancer cases (327 patients) who received surgery were divided into three groups, consisting of a premenopause group younger than 50 years of age (group A, N = 144), a postmenopause group younger than 70 years of age (group B, N = 140), and elderly cases 70 years of age or older (group C, N = 48). A positive node involvement was seen in about 40% of all cases, but the lymph node positivity of group C was significantly lower than that of group A or B. The postoperative 5-year survival rates of groups A, B, and C were 88.9%, 87.5%, and 89.4% at all stages, and 90.2%, 86.2%, and 91.4% at stages I and II, respectively. Only in group C did survival rates show no significant difference between node status. We conclude that both radical and cosmetic surgical treatments performed in elderly breast cancer patients aged 70 years or older are as effective as in younger breast cancer patients.


Assuntos
Neoplasias da Mama/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/mortalidade , Neoplasias da Mama/patologia , Feminino , Humanos , Mastectomia Radical Modificada , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Análise de Sobrevida
19.
Jpn J Thorac Cardiovasc Surg ; 52(12): 592-6, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15651410

RESUMO

Airway stenting for severe central airway stenosis is inherently a dangerous procedure. There is the risk of critical airway obstruction due to bleeding, tumor debris, and airway perforation during the procedure. Once such situations occur, percutaneous cardiopulmonary support (PCPS) can be one of the most valuable rescue options to prevent critical hypoxic complications. At our institute, four of 49 patients who received stenting or other airway intervention required PCPS support (8%). Two of these cases required PCPS to be performed in an emergency setting during the procedure while the procedure was elective in the other 2. All procedures were performed effectively and safely without any complications caused by PCPS, including massive airway bleeding due to anticoagulant treatment. Patients were able to be weaned off PCPS uneventfully. PCPS is considered to be a valuable procedure in remedying critical hypoxic situations during airway intervention.


Assuntos
Obstrução das Vias Respiratórias/terapia , Respiração , Stents , Estenose Traqueal/terapia , Adolescente , Obstrução das Vias Respiratórias/fisiopatologia , Ponte Cardiopulmonar , Neoplasias Esofágicas/complicações , Feminino , Humanos , Neoplasias Pulmonares/complicações , Masculino , Pessoa de Meia-Idade , Estenose Traqueal/fisiopatologia
20.
Eur J Prev Cardiol ; 21(12): 1481-3, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23897898

RESUMO

Pulmonary hypertension (PH), which is classified as group 5 in the clinical classification of PH, is sometimes a complication of Pulmonary langerhans cell histiocytosis (PLCH), and is associated with high mortality. A 36-year-old woman had suffered from severe dyspnea 9 years previously and was diagnosed with PLCH and was on a waiting list for a lung transplant. Right heart failure had been observed and the mean pulmonary artery pressure was over 40 mmHg. The patient was diagnosed as PLCH with PH. After combined treatment with exercise rehabilitation and bosentan for 6 months, the cardiothoracic ratio, brain natriuretic peptide, and bodyweight were significantly decreased (cardiothoracic ratio from 43 to 38%, brain natriuretic peptide from 284 to10 pg/ml and bodyweight from 63 to 58 kg). Six-minute walk test also improved from 214 to 275 meters and the SF36 score for screening of depressive and anxiety disorders was improved. This is the report demonstrating the efficacy and safety of cardiac rehabilitation in combination with bosentan in a single patient with PLCH associated with PH.


Assuntos
Anti-Hipertensivos/uso terapêutico , Antagonistas dos Receptores de Endotelina/uso terapêutico , Terapia por Exercício , Insuficiência Cardíaca/reabilitação , Histiocitose de Células de Langerhans/complicações , Hipertensão Pulmonar/tratamento farmacológico , Sulfonamidas/uso terapêutico , Adulto , Bosentana , Tolerância ao Exercício/efeitos dos fármacos , Feminino , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/etiologia , Insuficiência Cardíaca/fisiopatologia , Hemodinâmica/efeitos dos fármacos , Histiocitose de Células de Langerhans/diagnóstico , Humanos , Hipertensão Pulmonar/diagnóstico , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/fisiopatologia , Tomografia por Emissão de Pósitrons , Recuperação de Função Fisiológica , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento
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