Detalhe da pesquisa
1.
Cigarette smoking enhances the metabolic activation of the polycyclic aromatic hydrocarbon phenanthrene in humans.
Carcinogenesis
; 42(4): 570-577, 2021 04 30.
Artigo
Inglês
| MEDLINE | ID: mdl-33319219
2.
Methyl DNA phosphate adduct formation in lung tumor tissue and adjacent normal tissue of lung cancer patients.
Carcinogenesis
; 40(11): 1387-1394, 2019 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30873516
3.
Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung.
Anal Chem
; 89(23): 12735-12742, 2017 12 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29111668
4.
Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.
Biomarkers
; 18(2): 144-50, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23336104
5.
Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.
J Pharmacol Exp Ther
; 342(3): 750-60, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22674470
6.
Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration.
J Pharmacol Exp Ther
; 338(1): 353-61, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21515812
7.
Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene.
Chem Res Toxicol
; 24(2): 262-8, 2011 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21229973
8.
Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation.
Chem Res Toxicol
; 24(1): 73-80, 2011 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-21049951
9.
Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides.
Chem Res Toxicol
; 24(2): 246-52, 2011 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21184614
10.
Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes.
Drug Metab Dispos
; 38(9): 1397-402, 2010 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-20547966
11.
Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies.
Chem Res Toxicol
; 23(5): 900-8, 2010 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-20369855
12.
Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1141: 122023, 2020 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32109746
13.
Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer.
Chem Res Toxicol
; 22(3): 426-32, 2009 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-19187038
14.
Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms.
Carcinogenesis
; 29(5): 937-43, 2008 May.
Artigo
Inglês
| MEDLINE | ID: mdl-18477646
15.
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Chem Res Toxicol
; 21(7): 1468-76, 2008 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18570389
16.
Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats.
Chem Res Toxicol
; 20(3): 543-9, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17291014
17.
Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers.
Chem Res Toxicol
; 19(9): 1234-40, 2006 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16978029
18.
Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine.
Chem Res Toxicol
; 19(2): 319-24, 2006 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-16485909