Assuntos
Infecções por Escherichia coli/mortalidade , Infecções por Klebsiella/mortalidade , Infecções por Proteus/mortalidade , Infecções por Pseudomonas/mortalidade , Sepse/mortalidade , Adolescente , Adulto , Fatores Etários , Idoso , Colistina/administração & dosagem , Infecção Hospitalar/complicações , Infecções por Escherichia coli/tratamento farmacológico , Feminino , Febre/complicações , Humanos , Canamicina/administração & dosagem , Infecções por Klebsiella/tratamento farmacológico , Contagem de Leucócitos , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Nitrogênio/sangue , Penicilinas/administração & dosagem , Infecções por Proteus/tratamento farmacológico , Infecções por Pseudomonas/tratamento farmacológico , Estudos Retrospectivos , Sepse/tratamento farmacológico , Fatores Sexuais , Choque/complicações , Uremia/complicaçõesRESUMO
Pickling cucumbers stored at five temperatures and four relative humidities were examined for growth of eight microbial groups, the activities of two enzyme systems (pectinolytic and cellulolytic), and weight loss. Twenty-four storage tests for 6 days each were conducted during the 2-year study. In general, microbial populations of the eight groups increased rapidly at the higher temperature (>21 C) and humidity (>70%) treatments. Moisture loss of the cucumbers was rapid with combinations of high temperatures and low humidities. The results suggest that the best environmental conditions for storage or transport of cucumbers would be a combination of low temperature (10 C) with high relative humidity (about 95%). These conditions minimized undesirable microbial, enzymatic, and physical changes of stored, pickling cucumbers.
Assuntos
Microbiologia de Alimentos , Indústria de Processamento de Alimentos , Umidade , Temperatura , Verduras , Bactérias/isolamento & purificação , Celulase/metabolismo , Celulose , Fungos/isolamento & purificação , Glicosídeo Hidrolases/metabolismo , Pectinas , Fatores de Tempo , Verduras/análiseRESUMO
Because no conclusive evidence as to the efficacy of maintenance chemotherapy in acute myelogenous leukemia (AML) existed, a study to obtain such information was done. Twenty-six adult patients with AML in whom complete remission had been achieved following induction chemotherapy were randomly assigned to receive either maintenance chemotherapy consisting of cytarabine and 6-thioguanine for two days each month or to receive no maintenance therapy. The data showed a significant difference in remission duration between the two groups, with median remission lengths for the maintained and unmaintained groups being 10.3 and 6.7 months, respectively (p<.05). In 46 percent of the maintained patients there were remissions lasting longer than 11 months, whereas in none of the unmaintained patients was there such a prolonged remission. No significant drug-induced toxicity was observed. That the prolonged exposure to these chemotherapeutic agents, which were also used in our induction program, did not adversely affect the rate of successful reinduction therapy was shown by identical 50 percent complete remission rates for second inductions in both groups. In patients with palpable splenomegaly at the time of diagnosis, there was no prolongation of remission with maintenance therapy. These data indicate the potential utility of maintenance chemotherapy for prolonging remission duration in acute myelogenous leukemia.