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In a previous paper, a model was developed for the nonlinear acoustic resistance for compact insertion elements. Within the model, two loss coefficients are used to tune the model for each type of element, and data were used to empirically determine these coefficients for an area contraction. This paper extends the nonlinear model, developing expressions based on physical principles for the forward and reverse loss coefficients for both an area contraction and orifice. In addition, experimental data for the acoustic resistance of both elements was taken using an impedance tube. Utilizing the expressions developed, the model compares favorably with the experimental data.
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INTRODUCTION: Occult spinal cord injury should be suspected based not only on the mechanism of trauma but also on the age of the patient. The pediatric spine has unique biomechanical and anatomical properties that must be considered carefully when evaluating spinal cord trauma. For instance, the hypermobility and elasticity of the spinal column in children often lead to self-reducing injuries that can mask spinal cord injury. CASE ILLUSTRATION: We present the case of a 22-month-old male patient who was found to have ligamentous injury detected by magnetic resonance imaging (MRI) in the upper cervical spine but missed by MRI in the lower thoracic spine. Furthermore, there was no spinal cord injury in the upper cervical spine, but indeed a serious insult in the thoracic region. Since the advent of MRI, spinal cord injury without radiographic abnormality (SCIWORA) has become increasingly rare but not altogether extinct. CONCLUSIONS: We present a noteworthy example of the inadequacy of MRI in revealing SCIWORA, a term that is antiquated as we combine the latest imaging techniques with a better understanding of the biomechanics of trauma and spine injury. Based on the literature and our case illustration, we believe that the biomechanics of the pediatric spine must be considered when children who may have sustained a SCIWORA are examined.
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Traumatismos da Medula Espinal/patologia , Vértebras Cervicais , Criança , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Vértebras TorácicasRESUMO
OBJECTIVE: Postoperative infection remains prevalent after spinal surgical procedures. Institutional protocols for infection prevention have improved rates of infection after spine surgery. However, prior studies have focused on only elective surgical patients. The aim of this study was to determine the efficacy of a multiinstitutional intraoperative sodium oxychlorosene-based infection prevention protocol for decreasing rate of infection after instrumented spinal surgery. METHODS: A retrospective analysis was performed at two tertiary care institutions with level I trauma programs, and patients who underwent posterior instrumented spinal fusion between January 1, 2011, and May 31, 2019, were included. Postoperative deep wound infection rates were captured before and after implementation of a multiinstitutional infection prevention protocol. Possible adverse outcomes related to infection prevention techniques were also examined. In addition, consecutive patients treated from January 1, 2018, to May 31, 2019, were prospectively included in a database to collect preoperative and postoperative spine-specific quality of life measures and to assess the impact of postoperative infection on quality of life. RESULTS: A total of 5047 patients fit the inclusion criteria. Of these, 1043 patients underwent surgery prior to protocol implementation. The infection rate of this cohort (3.5%) decreased significantly after protocol implementation (1.2%, p < 0.001). Postoperative sterile seroma rates did not differ between the preprotocol and postprotocol groups (0.7% vs 0.7%, p = 0.5). In the 1031 patients who underwent surgery between January 2018 and May 2019, the fusion rate was 89.2%. Quality of life outcomes between patients with infection and those without infection were similar, although statistical power was limited owing to the low rate of infection. Notably, 2 of 10 patients who developed deep wound infection died of infection-related complications. CONCLUSIONS: An intraoperative sodium oxychlorosene-based infection prevention protocol helped to significantly decrease the rate of infection after spine surgery without negatively impacting other postoperative procedure-related metrics. Postoperative wound infection may be associated with higher-than-expected rate of postoperative mortality.
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Fusão Vertebral , Infecção da Ferida Cirúrgica , Benzenossulfonatos , Humanos , Qualidade de Vida , Estudos Retrospectivos , Sódio , Fusão Vertebral/efeitos adversos , Fusão Vertebral/métodos , Coluna Vertebral/cirurgia , Infecção da Ferida Cirúrgica/epidemiologia , Infecção da Ferida Cirúrgica/etiologia , Infecção da Ferida Cirúrgica/prevenção & controleRESUMO
OBJECT: The small diameter of the pedicle can make C-7 pedicle screw insertion dangerous. Although transfacet screws have been studied biomechanically when used in pinning joints, they have not been well studied when used as part of a C7-T1 screw/rod construct. The authors therefore compared C7-T1 fixation using a C-7 transfacet screw/T-1 pedicle screw construct with a construct composed of pedicle screws at both levels. METHODS: Each rigid posterior screw/rod construct was placed in 7 human cadaveric C6-T2 specimens (14 total). Specimens were tested in normal condition, after 2-column instability, and once fixated. Nondestructive, nonconstraining pure moments (maximum 1.5 Nm) were applied to induce flexion, extension, lateral bending, and axial rotation while recording 3D motion optoelectronically. The entire construct was then loaded to failure by dorsal linear force. RESULTS: There was no significant difference in angular range of motion between the 2 instrumented groups during any loading mode (p > 0.11, nonpaired t-tests). Both constructs reduced motion to < 2 degrees in any direction and allowed significantly less motion than in the normal condition. The C-7 facet screw/T-1 pedicle screw construct allowed a small but significantly greater lax zone than the pedicle screw/rod construct during lateral bending, and it failed under significantly less load than the pedicle screw/rod construct (p < 0.001). CONCLUSIONS: When C-7 transfacet screws are connected to T-1 pedicle screws, they provide equivalent stability of constructs formed by pedicle screws at both levels. Although less resistant to failure, the transfacet screw construct should be a viable alternative in patients with healthy bone.
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Parafusos Ósseos , Vértebras Cervicais/cirurgia , Fixação de Fratura , Amplitude de Movimento Articular/fisiologia , Articulação Zigapofisária/fisiopatologia , Articulação Zigapofisária/cirurgia , Idoso , Fenômenos Biomecânicos/fisiologia , Cadáver , Análise de Falha de Equipamento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Suporte de Carga/fisiologiaRESUMO
OBJECT: Sonic hedgehog (Shh) is a glycoprotein molecule that upregulates the transcription factor Gli1. The Shh protein plays a critical role in the proliferation of endogenous neural precursor cells when directly injected into the spinal cord after a spinal cord injury in adult rodents. Small-molecule agonists of the hedgehog (Hh) pathway were used in an attempt to reproduce these findings through intravenous administration. METHODS: The expression of Gli1 was measured in rat spinal cord after the intravenous administration of an Hh agonist. Ten adult rats received a moderate contusion and were treated with either an Hh agonist (10 mg/kg, intravenously) or vehicle (5 rodents per group) 1 hour and 4 days after injury. The rats were killed 5 days postinjury. Tissue samples were immediately placed in fixative. Samples were immunohistochemically stained for neural precursor cells, and these cells were counted. RESULTS: Systemic dosing with an Hh agonist significantly upregulated Gli1 expression in the spinal cord (p < 0.005). After spinal contusion, animals treated with the Hh agonist had significantly more nestin-positive neural precursor cells around the rim of the lesion cavity than in vehicle-treated controls (means +/- SDs, 46.9 +/- 12.9 vs 20.9 +/- 8.3 cells/hpf, respectively, p < 0.005). There was no significant difference in the area of white matter injury between the groups. CONCLUSIONS: An intravenous Hh agonist at doses that upregulate spinal cord Gli1 transcription also increases the population of neural precursor cells after spinal cord injury in adult rats. These data support previous findings based on injections of Shh protein directly into the spinal cord.
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Contusões/patologia , Contusões/terapia , Proteínas Hedgehog/agonistas , Traumatismos da Medula Espinal/patologia , Traumatismos da Medula Espinal/terapia , Células-Tronco/efeitos dos fármacos , Animais , Proliferação de Células/efeitos dos fármacos , Contusões/metabolismo , Proteínas Hedgehog/administração & dosagem , Injeções Intraperitoneais , Injeções Intravenosas , Proteínas de Filamentos Intermediários/metabolismo , Fatores de Transcrição Kruppel-Like/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Nestina , Ratos , Ratos Sprague-Dawley , Traumatismos da Medula Espinal/metabolismo , Células-Tronco/fisiologia , Vértebras Torácicas , Proteína GLI1 em Dedos de ZincoRESUMO
Lower back pain from spondylolysis historically has been treated with a variety of options ranging from conservative care to open fusion. The authors describe the novel technique of minimally invasive bilateral pars interarticularis screw placement by utilizing intraoperative 3D imaging and frameless navigation in a 17-year-old male athlete. This technique is a modification of the open technique first described in 1970 by Buck and has the advantages of minimal dissection requirements with improved screw trajectory visualization. The patient's postoperative course is discussed, followed by a brief literature review of pars interarticularis defect treatment.
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Vértebras Lombares/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Espondilólise/cirurgia , Cirurgia Assistida por Computador/métodos , Adolescente , Traumatismos em Atletas/diagnóstico , Traumatismos em Atletas/cirurgia , Humanos , Dor Lombar/diagnóstico , Dor Lombar/cirurgia , Vértebras Lombares/patologia , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação , Espondilólise/diagnóstico , Cirurgia Assistida por Computador/instrumentaçãoRESUMO
OBJECT: Venous stasis and intrathecal hypertension are believed to play a significant role in the hypoperfusion present in the spinal cord following injury. Lowering the intrathecal pressure via cerebrospinal fluid (CSF) drainage has been effective in treating spinal cord ischemia during aorta surgery. The purpose of the present study was to determine whether CSF drainage increases spinal cord perfusion and improves outcome after spinal injury in an animal model. METHODS: Anesthetized adult rabbits were subjected to a severe contusion spinal cord injury (SCI). Cerebrospinal fluid was then drained via a catheter to lower the intrathecal pressure by 10 mm Hg. Tissue perfusion was assessed at the site of injury, and values obtained before and after CSF drainage were compared. Two other cohorts of animals were subjected to SCI: 1 group subsequently underwent CSF drainage and the other did not. Results of histological analysis, motor evoked potential and motor function testing were compared between the 2 cohorts at 4 weeks postinjury. RESULTS: Cerebrospinal fluid drainage led to no significant improvement in spinal cord tissue perfusion. Four weeks after injury, the animals that underwent CSF drainage demonstrated significantly smaller areas of tissue damage at the injury site. There were no differences in motor evoked potentials or motor score outcomes at 4 weeks postinjury. CONCLUSIONS: Cerebrospinal fluid drainage effectively lowers intrathecal pressure and decreases the amount of tissue damage in an animal model of spinal cord injury. Further studies are needed to determine whether different draining regimens can improve motor or electrophysiological outcomes.
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Líquido Cefalorraquidiano , Drenagem , Perfusão/métodos , Traumatismos da Medula Espinal/fisiopatologia , Traumatismos da Medula Espinal/terapia , Animais , Pressão Sanguínea/fisiologia , Pressão do Líquido Cefalorraquidiano/fisiologia , Modelos Animais de Doenças , Potencial Evocado Motor , Injeções Espinhais/métodos , Laminectomia/métodos , CoelhosRESUMO
The development of an acute traumatic spinal cord injury (SCI) inevitably leads to a complex cascade of ischemia and inflammation that results in significant scar tissue formation. The development of such scar tissue provides a severe impediment to neural regeneration and healing with restoration of function. A multimodal approach to treatment is required because SCIs occur with differing levels of severity and over different lengths of time. To achieve significant breakthroughs in outcomes, such approaches must combine both neuroprotective and neuroregenerative treatments. Novel techniques modulating endogenous stem cells demonstrate great promise in promoting neuroregeneration and restoring function.
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Protocolos Clínicos , Traumatismos da Medula Espinal/terapia , Transplante de Células-Tronco/métodos , Células-Tronco/fisiologia , Animais , Humanos , Regeneração Nervosa/fisiologia , Recuperação de Função Fisiológica , Traumatismos da Medula Espinal/patologia , Traumatismos da Medula Espinal/fisiopatologiaRESUMO
Spinal meningeal melanocytomas are rare lesions that are histologically benign and can behave aggressively, with local infiltration. The authors present their experience with intramedullary spinal cord melanocytomas consisting of 3 cases, which represents the second largest series in the literature. A retrospective chart review was performed following identification of all spinal melanocytomas treated at the author's institution, based on information obtained from a neuropathology database. The charts were reviewed for patient demographics, surgical procedure, clinical outcome, and long-term tumor progression. Three patients were identified in whom spinal melanocytoma had been diagnosed between 1989 and 2006. The patients' ages were 37, 37, and 48 years, and the location of their tumor was C1-3, T9-10, and T-12, respectively. All 3 had complete resection with no adjuvant radiotherapy during follow-up periods of 16, 38, and 185 months, respectively. One patient demonstrated a recurrence 29 months after resection and the other 2 patients have demonstrated asymptomatic recurrences on imaging studies obtained at 16 and 38 months following resection. With these cases added to the available literature, the evidence strongly suggests that complete resection is the treatment of choice for spinal melanocytomas. Even with complete resection, recurrences are common and close follow-up is needed for the long term in these patients. Radiation therapy should be reserved for those cases in which complete resection is not possible or in which there is recurrence.
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Nevo Pigmentado/cirurgia , Neoplasias da Medula Espinal/cirurgia , Adulto , Vértebras Cervicais , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Estudos Retrospectivos , Vértebras Torácicas , Resultado do TratamentoRESUMO
OBJECT: Lateral mass screws are traditionally used to fixate the subaxial cervical spine, while pedicle screws are used in the thoracic spine. Lateral mass fixation at C-7 is challenging due to thin facets, and placing pedicle screws is difficult due to the narrow pedicles. The authors describe their clinical experience with a novel technique for transfacet screw placement for fixation at C-7. METHODS: A retrospective chart review was undertaken in all patients who underwent transfacet screw placement at C-7. The technique of screw insertion was the same for each patient. Polyaxial screws between 8- and 10-mm-long were used in each case and placed through the facet from a perpendicular orientation. Postoperative radiography and clinical follow-up were analyzed for aberrant screw placement or construct failure. RESULTS: Ten patients underwent C-7 transfacet screw placement between June 2006 and March 2007. In all but 1 patient screws were placed bilaterally, and the construct lengths ranged from C-3 to T-5. One patient with a unilateral screw had a prior facet fracture that precluded bilateral screw placement. There were no intraoperative complications or screw failures in these patients. After an average of 6 months of follow-up there were no hardware failures, and all patients showed excellent alignment. CONCLUSIONS: The authors present the first clinical demonstration of a novel technique of posterior transfacet screw placement at C-7. These results provide evidence that this technique is safe to perform and adds stability to cervicothoracic fixation.
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Parafusos Ósseos , Vértebras Cervicais/cirurgia , Idoso , Feminino , Humanos , Instabilidade Articular/cirurgia , Masculino , Pessoa de Meia-Idade , Doenças da Coluna Vertebral/cirurgia , Fusão Vertebral/instrumentação , Fusão Vertebral/métodosRESUMO
OBJECT: The stability provided by 3 occipitoatlantal fixation techniques (occiput [Oc]-C1 transarticular screws, occipital keel screws rigidly interconnected with C-1 lateral mass screws, and suboccipital/sublaminar wired contoured rod) were compared. METHODS: Seven human cadaveric specimens received transarticular screws and 7 received occipital keel-C1 lateral mass screws. All specimens later underwent contoured rod fixation. All conditions were studied with and without placement of a structural graft wired between the skull base and C-1 lamina. Specimens were loaded quasistatically using pure moments to induce flexion, extension, lateral bending, and axial rotation while recording segmental motion optoelectronically. Flexibility was measured immediately postoperatively and after 10,000 cycles of fatigue. RESULTS: Application of Oc-C1 transarticular screws, with a wired graft, reduced the mean range of motion (ROM) to 3% of normal. Occipital keel-C1 lateral mass screws (also with graft) offered less stability than transarticular screws during extension and lateral bending (p < 0.02), reducing ROM to 17% of normal. The wired contoured rod reduced motion to 31% of normal, providing significantly less stability than either screw fixation technique. Fatigue increased motion in constructs fitted with transarticular screws, keel screws/lateral mass screw constructs, and contoured wired rods, by means of 19, 5, and 26%, respectively. In all constructs, adding a structural graft significantly improved stability, but the extent depended on the loading direction. CONCLUSIONS: Assuming the presence of mild C1-2 instability, Oc-C1 transarticular screws and occipital keel-C1 lateral mass screws are approximately equivalent in performance for occipitoatlantal stabilization in promoting fusion. A posteriorly wired contoured rod is less likely to provide a good fusion environment because of less stabilizing potential and a greater likelihood of loosening with fatigue.
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Articulação Atlantoccipital/fisiopatologia , Articulação Atlantoccipital/cirurgia , Parafusos Ósseos , Luxações Articulares/cirurgia , Amplitude de Movimento Articular/fisiologia , Fusão Vertebral/métodos , Fenômenos Biomecânicos , Cadáver , Feminino , Humanos , Luxações Articulares/fisiopatologia , Masculino , Pessoa de Meia-Idade , Fusão Vertebral/instrumentaçãoRESUMO
The transbasal approach offers extradural exposure of the anterior midline skull base transcranially. It can be used to treat a variety of conditions, including trauma, craniofacial deformity, and tumors. This approach has been modified to enhance basal access. This article reviews the principle differences among modifications to the transbasal approach and introduces a new classification scheme. The rationale is to offer a uniform nomenclature to facilitate discussion of these approaches, their indications, and related issues.
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OBJECT: Skull base fractures are often associated with potentially devastating injuries to major neural arteries in the head and neck, but the incidence and pattern of this association are unknown. METHODS: Between April and September 2002, 1738 Level 1 trauma patients were admitted to St. Joseph's Hospital and Medical Center in Phoenix, Arizona. Among them, a skull base fracture was diagnosed in 78 patients following computed tomography (CT) scans. Seven patients had no neurovascular imaging performed and were excluded. Altogether, 71 patients who received a diagnosis of skull base fractures after CT and who also underwent a neurovascular imaging study were included (54 men and 17 women, mean age 29 years, range 1-83 years). Patients underwent CT angiography, magnetic resonance angiography, or digital subtraction angiography of the head and craniovertebral junction, or combinations thereof. RESULTS: Nine neurovascular injuries were identified in six (8.5%) of the 71 patients. Fractures of the clivus were very likely to be associated with neurovascular injury (p < 0.001). A high risk of neurovascular injury showed a strong tendency to be associated with fractures of the sella turcica-sphenoid sinus complex (p = 0.07). CONCLUSIONS: The risk of associated blunt neurovascular injury appears to be significant in Level 1 trauma patients in whom a diagnosis of skull base fracture has been made using CT. The incidence of neurovascular trauma is particularly high in patients with clival fractures. The authors recommend neurovascular imaging for Level 1 trauma patients with a high-risk fracture pattern of the central skull base to rule out cerebrovascular injuries.
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Traumatismo Cerebrovascular/epidemiologia , Base do Crânio/lesões , Fraturas Cranianas/complicações , Ferimentos não Penetrantes/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Traumatismo Cerebrovascular/diagnóstico por imagem , Criança , Pré-Escolar , Feminino , Escala de Coma de Glasgow , Humanos , Incidência , Lactente , Masculino , Pessoa de Meia-Idade , Radiografia , Estudos Retrospectivos , Fraturas Cranianas/diagnóstico por imagem , Ferimentos não Penetrantes/diagnóstico por imagemRESUMO
OBJECT: The authors evaluated the mechanisms and patterns of thoracic, lumbar, and sacral spinal injuries in a pediatric population as well as factors affecting the management and outcome of these injuries. METHODS: The records of 89 patients (46 boys and 43 girls; mean age 13.2 years, range 3-16 years) with thoracic, lumbar, or sacral injuries were reviewed. Motor vehicle accidents were the most common cause of injury. Eighty-two patients (92.1%) were between 10 and 16 years old, and seven (7.9%) were between 3 and 9 years old. Patient injuries included fracture (91%), fracture and dislocation (6.7%), dislocation (1.1%), and ligamentous injury (1.1%). The L2-5 region was the most common injury site (29.8%) and the sacrum the least common injury site (5%). At the time of presentation 85.4% of the patients were neurologically intact, 4.5% had incomplete injuries, and 10.1% had complete injuries. Twenty-six percent of patients underwent surgery for their injuries whereas 76% received nonsurgical treatment. In patients treated surgically, an anterior approach was used in six patients (6.7%), a posterior approach in 16 (18%), and a combined approach in one (1.1%). Postoperatively, six patients (26.1%) with neurological deficits improved, one of whom recovered fully from an initially complete injury. CONCLUSIONS: Thoracic and lumbar spine injuries were most common in children older than 9 years. Multilevel injuries were common and warranted imaging evaluation of the entire spinal column. Most patients were treated conservatively. The prognosis for neurological recovery is related to the initial severity of the neurological injuries. Some pediatric patients with devastating spinal cord injuries can recover substantial neurological function.
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Vértebras Lombares/lesões , Sacro/lesões , Traumatismos da Coluna Vertebral/epidemiologia , Traumatismos da Coluna Vertebral/terapia , Vértebras Torácicas/lesões , Acidentes de Trânsito , Adolescente , Distribuição por Idade , Criança , Pré-Escolar , Feminino , Humanos , Luxações Articulares/epidemiologia , Ligamentos/lesões , Imageamento por Ressonância Magnética , Masculino , Doenças do Sistema Nervoso/etiologia , Procedimentos Neurocirúrgicos , Prognóstico , Fraturas da Coluna Vertebral/epidemiologia , Fraturas da Coluna Vertebral/terapia , Traumatismos da Coluna Vertebral/complicações , Traumatismos da Coluna Vertebral/etiologia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
OBJECT: Although rare, traumatic occipitoatlantal dislocation (OAD) injuries are associated with a high mortality rate. The authors evaluated the imaging and clinical factors that determined treatment and were predictive of outcomes, respectively, in survivors of this injury. METHODS: The medical records and imaging studies obtained in 33 patients with OAD were reviewed retrospectively. Clinical factors that predicted outcomes, especially neurological injury at presentation and imaging findings, were evaluated. The most sensitive method for the diagnosis of OAD was the measurement of basion axial-basion dens interval on computed tomography (CT) scanning. Five patients with severe traumatic brain injuries (TBIs) were not treated and subsequently died. Of the 28 patients in whom treatment was performed, 23 underwent fusion and five were fitted with an external orthosis. Abnormal findings of the occipitoatlantal ligaments on magnetic resonance (MR) imaging, associated with no or questionable abnormalities on CT scanning, provided the rationale for nonoperative treatment. Of the 28 patients treated for their injuries, perioperative death occurred in five, three of whom had presented with severe neurological injuries. The mortality rate was highest in patients with a TBI at presentation. The mortality rate was lower in patients presenting with a spinal cord injury, but in this group there was a higher rate of persistent neurological deficits. CONCLUSIONS: The spines in patients with CT-documented OAD are most likely unstable and need surgical fixation. In patients for whom CT findings are normal and MR imaging findings suggest marginal abnormalities, nonoperative treatment should be considered. The best predictors of outcome were severe brain or upper cervical injuries at initial presentation.
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Articulação Atlantoccipital/lesões , Lesões Encefálicas/complicações , Luxações Articulares/complicações , Imageamento por Ressonância Magnética , Traumatismos da Medula Espinal/complicações , Sobreviventes , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Lesões Encefálicas/mortalidade , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Luxações Articulares/diagnóstico , Luxações Articulares/mortalidade , Luxações Articulares/terapia , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/etiologia , Aparelhos Ortopédicos , Prognóstico , Fusão Vertebral/mortalidadeRESUMO
OBJECT: Therapies that use bioactive materials as replacement extracellular matrices may hold the potential to mitigate the inhibition of regeneration observed after central nervous system trauma. Hyaluronic acid (HA), a nonsulfated glycosaminoglycan ubiquitous in all tissues, was investigated as a potential neural tissue engineering matrix. METHODS: Chick dorsal root ganglia were cultured in 3D hydrogel matrices composed of cross-linked thiol-modified HA or fibrin. Samples were cultured and images were acquired at 48-, 60-, and 192-hour time points. Images of all samples were analyzed at 48 hours of incubation to quantify the extent of neurite growth. Cultures in crosslinked thiolated HA exhibited more than a 50% increase in neurite length compared with fibrin samples. Furthermore, cross-linked thiolated HA supported neurites for the entire duration of the culture period, whereas fibrin cultures exhibited collapsed and degenerating extensions beyond 60 hours. Two concentrations of the thiolated HA (0.5 and 1%) were then placed at the site of a complete thoracic spinal cord transection in rats. The ability of the polymer to promote regeneration was tested using motor evoked potentials, retrograde axonal labeling, and behavioral assessments. There were no differences in any of the parameters between rats treated with the polymer and controls. CONCLUSIONS: The use of a cross-linked HA scaffold promoted robust neurite outgrowth. Although there was no benefit from the polymer in a rodent spinal cord injury model, the findings in this study represent an early step in the development of semisynthetic extracellular matrice scaffolds for the treatment of neuronal injury.
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Ácido Hialurônico/química , Ácido Hialurônico/farmacologia , Neuritos/efeitos dos fármacos , Traumatismos da Medula Espinal/fisiopatologia , Animais , Embrião de Galinha , Reagentes de Ligações Cruzadas , Relação Dose-Resposta a Droga , Fibrina/farmacologia , Gânglios Espinais/efeitos dos fármacos , Gânglios Espinais/patologia , Gânglios Espinais/fisiopatologia , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/metabolismo , Hidrogéis/farmacologia , Masculino , Neuritos/patologia , Ratos , Ratos Sprague-Dawley , Recuperação de Função Fisiológica , Traumatismos da Medula Espinal/patologia , Compostos de Sulfidrila/metabolismo , Engenharia Tecidual/métodosRESUMO
BACKGROUND: Although the bedside twist drill craniostomy is used to treat chronic subdural hematomas, the efficacy of this technique has not been compared with that of standard treatments (operative bur hole or craniotomy). METHODS: Twist drill craniostomy was compared with operative bur hole or craniotomy in a prospective nonrandomized trial. The inclusion criteria were computed tomographic evidence of chronic subdural hematoma (isodense or hypodense compared with brain) and symptoms indicating the need for drainage. Selection of the procedure depended on the on-call surgeon's preference. Clinical success of the procedure, recurrence, length of hospitalization, complications, and neurologic outcome were compared. RESULTS: Between August 2001 and October 2002, 79 consecutive patients with 91 chronic subdural hematomas were treated (67 unilateral and 12 bilateral) at our institution. Fifty-five patients were treated with twist drill craniostomy and 24 with bur hole or craniotomy. There were no differences in the mean age of presentation, thickness of hematoma, length of hospitalization, reoperation rate, mortality rates, or ability to be discharged to home between the 2 groups. There was no difference in the neurologic outcomes in the 57 of the 79 patients available for follow-up. CONCLUSIONS: Twist drill craniostomy performed at the bedside is just as effective in treating chronic subdural hematomas as bur holes or craniotomy in the operating room. This procedure can most often be the first line of treatment in patients with symptomatic chronic subdural hematomas.
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Craniotomia/instrumentação , Craniotomia/métodos , Hematoma Subdural Crônico/cirurgia , Idoso , Humanos , Tempo de Internação , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Prospectivos , Reoperação , Resultado do TratamentoRESUMO
BACKGROUND CONTEXT: Thoracic hyperextension fracture-dislocation is a rare pattern of traumatic spinal injury, typically associated with gross spinal instability and severe neurological deficit. These extremely unstable injuries require internal fixation despite their potentially benign clinical presentation. PURPOSE: We present a patient with a thoracic distraction injury who remained neurologically intact. METHODS: The patient underwent thoracoscopic reduction and anterior fixation of the thoracic spine using a paired screw-rod construct. RESULTS: Postoperatively, the patient remained neurologically intact and had no complications related to his thoracic fixation and fusion. Follow-up radiographs showed maintenance of thoracic alignment and bony fusion. CONCLUSIONS: The endoscopic approach to the anterior thoracic spine was an excellent treatment option for this thoracic distraction injury.
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Acidentes de Trânsito , Motocicletas , Fraturas da Coluna Vertebral/cirurgia , Vértebras Torácicas/cirurgia , Toracoscopia , Fixação Interna de Fraturas , Humanos , Masculino , Pessoa de Meia-Idade , Próteses e Implantes , Toracoscopia/métodos , Resultado do TratamentoRESUMO
Because skeletal dysplasias are primary disorders of bone, they have not been commonly understood as neurosurgical diseases. Nevertheless, neurosurgical complications are commonly encountered in many cases of dysplasia syndromes. The authors present two cases of skeletal dysplasia that caused overt instability of the cervical spine. One patient with a diagnosis of Gorham disease of the cervical spine was treated with prolonged fixation in a halo brace after an initial attempt at instrumentation with a posterior occiput--C4 fusion. The other patient, who at birth was identified to have camptomelic dysplasia, has been treated conservatively from the outset. Although these two patients presented with different disorders--in one patient adequate mature bone never formed and in the other patient progressive bone loss became apparent after a seemingly normal initial development--these cases demonstrate unequivocally that surgical options for fusion are ultimately limited by the quality of the underlying bone. In patients in whom the bone itself is inadequate for use as a substrate for fusion, there are currently limited treatment options. Future improvements in our understanding of chondrogenesis and ossification may lead to the design of superior methods of encouraging fusion in these patients; however, at the present time, long-term maintenance in a halo brace may, in fact, be the only treatment.
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Doenças do Desenvolvimento Ósseo/complicações , Vértebras Cervicais , Instabilidade Articular/etiologia , Doenças da Coluna Vertebral/etiologia , Braquetes , Criança , Humanos , Recém-Nascido , Instabilidade Articular/diagnóstico , Instabilidade Articular/terapia , Cifose/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Osteólise Essencial/complicações , Doenças da Coluna Vertebral/diagnóstico , Doenças da Coluna Vertebral/terapia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
The management of spinal meningiomas with extensive involvement of the dura mater is controversial. The principal difficulty in performing a resection is the potential for complications associated with this approach. The authors present the case of a pregnant 35-year-old woman in whom bilateral lower-extremity numbness, weakness, gait ataxia, and myelopathy developed. Magnetic resonance imaging showed a recurrent thoracic meningioma with extensive infiltration of the dura mater. Durectomy, complete resection, and reconstruction were performed. The patient has not experienced a recurrence 21 months after her treatment. This case illustrates that thoracic spinal meningiomas with extensive dural involvement can be resected safely with a complete durectomy. The novel dural reconstruction involving the implantation of a fascia lata and bovine pericardium allograft is an effective way to reconstruct the dura to create an adequate barrier to cerebrospinal fluid.