Detalhe da pesquisa
1.
Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy.
Toxicol Appl Pharmacol
; 483: 116837, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38278496
2.
Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities.
Mol Ther
; 29(2): 555-570, 2021 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33038322
3.
Current practices for QSP model assessment: an IQ consortium survey.
J Pharmacokinet Pharmacodyn
; 2022 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35953664
4.
gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development.
J Pharmacokinet Pharmacodyn
; 45(2): 259-275, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29302838
5.
"Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy".
NPJ Syst Biol Appl
; 10(1): 11, 2024 Jan 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38278838
6.
Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.
Br J Pharmacol
; 181(13): 2033-2052, 2024 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-38486310
7.
A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.
Pharmaceutics
; 16(5)2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38794321
8.
Multi-scale modeling of HIV infection in vitro and APOBEC3G-based anti-retroviral therapy.
PLoS Comput Biol
; 8(2): e1002371, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22346743
9.
Systems-based digital twins to help characterize clinical dose-response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL.
Clin Transl Sci
; 16(7): 1134-1148, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36908269
10.
Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.
Eur J Pharm Sci
; 186: 106450, 2023 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37084985
11.
Quantitative Clinical Pharmacology of T-Cell Engaging Bispecifics: Current Perspectives and Opportunities.
Clin Transl Sci
; 14(1): 75-85, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32882099
12.
gQSPSim: A SimBiology-Based GUI for Standardized QSP Model Development and Application.
CPT Pharmacometrics Syst Pharmacol
; 9(3): 165-176, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31957304
13.
Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling.
NPJ Syst Biol Appl
; 6(1): 28, 2020 08 28.
Artigo
Inglês
| MEDLINE | ID: mdl-32859946
14.
Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection.
PLoS One
; 10(5): e0126843, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25984721
15.
APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study.
PLoS One
; 8(5): e63984, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23724012