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1.
Nano Lett ; 23(4): 1371-1378, 2023 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-36735577

RESUMO

Pottery is the oldest art and plays a landmark role in human civilization. The repair of ceramic relics often uses acrylic resins and cyanoacrylate adhesives. However, existing adhesives often take hours to get cured, and wet adhesion is not possible. We herein propose a redox initiator-triggered hydrogel adhesive, of which robust (∼700 J m-2) and wet adhesion with potsherds can be achieved within a few seconds. The high toughness lies in the self-limited delocalized rupture of the porous interface, and the wet adhesion is due to the hydrophilic precursor and its free radical polymerization. The hydrogel adhesive also exhibits high aging resistance for stable preservation of ∼400 annuals. We have applied the adhesive to the restoration of artifacts excavated from Yinxu, Anyang (∼1300 BC) and the Xia Jiao Shan site (∼4000 BC, Neolithic), and the adhesive is expected to be extended to applications beyond archeology.

2.
J Esthet Restor Dent ; 34(8): 1179-1196, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-35968802

RESUMO

OBJECTIVE: To review four types of three-dimensional imaging devices: intraoral scanners, extraoral scanners, cone-beam computed tomography (CBCT), and facial scanners, in terms of their development, technologies, advantages, disadvantages, accuracy, influencing factors, and applications in dentistry. METHODS: PubMed (National Library of Medicine) and Google Scholar databases were searched. Additionally, the scanner manufacturers' websites were accessed to obtain relevant data. Four authors independently selected the articles, books, and websites. To exclude duplicates and scrutinize the data, they were uploaded to Mendeley Data. In total, 135 articles, two books, and 17 websites were included. RESULTS: Research and clinical practice have shown that oral and facial scanners and CBCT can be used widely in various areas of dentistry with high accuracy. CONCLUSION: Although further advancement of these devices is desirable, there is no doubt that digital technology represents the future of dentistry. Furthermore, the combined use of different devices may bring dentistry into a new era. These four devices will play a significant role in clinical utility with high accuracy. The combined use of these devices should be explored further. CLINICAL SIGNIFICANCE: The four devices will play a significant role in clinical use with high accuracy. The combined use of these devices should be explored further.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Imageamento Tridimensional , Face , Odontologia
3.
J Nanobiotechnology ; 19(1): 111, 2021 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-33874945

RESUMO

BACKGROUND: Nanocarriers-derived antitumor therapeutics are often associated with issues of limited tumor penetration and dissatisfactory antitumor efficacies. Some multistage delivery systems have been constructed to address these issues, but they are often accompanied with complicated manufacture processes and undesirable biocompatibility, which hinder their further application in clinical practices. Herein, a novel dual-responsive multi-pocket nanoparticle was conveniently constructed through self-assembly and cross-linking of amphiphilic methoxypolyethylene glycol-lipoic acid (mPEG-LA) conjugates to enhance tumor penetration and antitumor efficacy. RESULTS: The multi-pocket nanoparticles (MPNs) had a relatively large size of ~ 170 nm at physiological pH which results in prolonged blood circulation and enhanced accumulation at the tumor site. But once extravasated into acidic tumor interstices, the increased solubility of PEG led to breakage of the supramolecular nanostructure and dissolution of MPNs to small-sized (< 20 nm) nanoparticles, promoting deep penetration and distribution in tumor tissues. Furthermore, MPNs exhibited not only an excellent stable nanostructure for antitumor doxorubicin (DOX) loading, but rapid dissociation of the nanostructure under an intracellular reductive environment. With the capacity of long blood circulation, deep tumor penetration and fast intracellular drug release, the DOX-loaded multi-pocket nanoparticles demonstrated superior antitumor activities against large 4T1 tumor (~ 250 mm3) bearing mice with reduced side effect. CONCLUSIONS: Our facile fabrication of multi-pocket nanoparticles provided a promising way in improving solid tumor penetration and achieving a great therapeutic efficacy.


Assuntos
Antineoplásicos/química , Antineoplásicos/farmacologia , Nanopartículas/química , Nanopartículas/uso terapêutico , Neoplasias/tratamento farmacológico , Ácido Tióctico/química , Ácido Tióctico/farmacocinética , Animais , Doxorrubicina/química , Doxorrubicina/farmacologia , Portadores de Fármacos/química , Sistemas de Liberação de Medicamentos/métodos , Liberação Controlada de Fármacos , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Nanoestruturas , Tamanho da Partícula , Polietilenoglicóis/química , Polietilenoglicóis/farmacologia , Solubilidade
4.
Mikrochim Acta ; 186(11): 686, 2019 10 08.
Artigo em Inglês | MEDLINE | ID: mdl-31595360

RESUMO

The authors describe boronate-modified hollow dummy template imprinted polymers (B-hDIPs) for selective and sensitive extraction of the catecholamines norepinephrine (NE), epinephrine (E), and dopamine (DA) from urine samples prior to their detection by HPLC with UV detector. The B-hDIPs were prepared by using (a) nano-TiO2 as the sacrificial support, (b) 3-carboxyphenylboronic acid (CPBA) as the boronate-affinity functional monomer, and (c) catechol which acts as dummy template. The nano-TiO2 can be etched off by using hydrofluoric acid to form the hollow imprint. The main advantages of using such hollow polymers arise from their controllable hole structure which favors template removal and fast mass transfer. The B-hDIPs material was characterized by FT-IR, transmission electron microscope, dynamic light scattering, X-ray photoelectron spectrum, and thermal gravimetric analysis. The effects of imprinting conditions, sample pH, sample flow rate, adsorbent amount, selectivity and competitive capacities were investigated. Under optimal conditions, the limits of detection for the catecholamines are in the range from 15 to 47 ng mL-1. The method was successfully applied to their determination of NE, E, and DA in spiked urine, with recoveries ranging from 63.4 to 106.2%. Graphical abstract Schematic presentation of boronate-modified hollow dummy template imprinted polymers as an adsorbent to extraction of the catecholamines (norepinephrine, epinephrine, and dopamine) from urine samples prior to their detection by HPLC-UV.

5.
Mikrochim Acta ; 185(1): 46, 2017 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-29594569

RESUMO

D-Glucose was used as a dummy template in a strategy to fabricate boronate-based hollow molecularly imprinted polymers (h-MIPs) for the recognition of glycosides. 3-Aminophenylboronic acid (APBA) was selected as the functional monomer to impart glycoside binding capability. A polystyrene core was synthesized via an emulsifier-free emulsion polymerization. It was then be corroded to form a hollow structure where the binding sites on the inner surface can be fully utilized. Adsorption studies indicate that the resulting h-MIPs can specifically recognize glycosides. The h-MIPs were applied as a sorbent for solid phase extraction of the glycosides (daidzin, glycitin, rutin, and genistin) in soy products. Following desorption with 1% TFA in acetonitrile-water (3:7, v/v), the glycosides were quantified by HPLC with UV detection. The detection limits for the glycosides range from 3.5 to 10.8 ng·mL-1. Graphical abstract Boronate-affinity hollow molecularly imprinted polymers using D-glucose as dummy template were prepared as solid phase extraction adsorbents for selective enrichment of glycosides in soy products prior to quantitation by HPLC-UV.

6.
Appl Microbiol Biotechnol ; 100(17): 7457-69, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27020282

RESUMO

Transmissible gastroenteritis coronavirus (TGEV) is a member of the genus Coronavirus, family Coronaviridae, order Nidovirales. TGEV is an enteropathogenic coronavirus that causes highly fatal acute diarrhoea in newborn pigs. An oral Lactobacillus casei (L. casei) vaccine against anti-transmissible gastroenteritis virus developed in our laboratory was used to study mucosal immune responses. In this L. casei vaccine, repetitive peptides expressed by L. casei (specifically the MDP and tuftsin fusion protein (MT)) were repeated 20 times and the D antigenic site of the TGEV spike (S) protein was repeated 6 times. Immunization with recombinant Lactobacillus is crucial for investigations of the effect of immunization, such as the first immunization time and dose. The first immunization is more important than the last immunization in the series. The recombinant Lactobacillus elicited specific systemic and mucosal immune responses. Recombinant L. casei had a strong potentiating effect on the cellular immunity induced by the oral L. casei vaccine. However, during TGEV infection, the systemic and local immune responses switched from Th1 to Th2-based immune responses. The systemic humoral immune response was stronger than the cellular immune response after TGEV infection. We found that the recombinant Lactobacillus stimulated IL-17 expression in both the systemic and mucosal immune responses against TGEV infection. Furthermore, the Lactobacillus vaccine stimulated an anti-TGEV infection Th17 pathway. The histopathological examination showed tremendous potential for recombinant Lactobacillus to enable rapid and effective treatment for TGEV with an intestinal tropism in piglets. The TGEV immune protection was primarily dependent on mucosal immunity.


Assuntos
Vacinas Bacterianas/imunologia , Gastroenterite/prevenção & controle , Lacticaseibacillus casei/imunologia , Células Th1/imunologia , Células Th2/imunologia , Vírus da Gastroenterite Transmissível/imunologia , Vacinas Virais/imunologia , Animais , Células Cultivadas , Gastroenterite/imunologia , Imunidade nas Mucosas/imunologia , Imunização , Imunoglobulina A/imunologia , Interleucina-17/biossíntese , Interleucina-17/imunologia , Suínos , Receptor 2 Toll-Like/biossíntese , Receptor 4 Toll-Like/biossíntese , Receptor Toll-Like 9/biossíntese , Tuftsina/genética
7.
J Neurochem ; 128(1): 173-85, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23895375

RESUMO

Methamphetamine and other drugs activate a small proportion of all neurons in the brain. We previously developed a fluorescence-activated cell sorting (FACS)-based method to characterize molecular alterations induced selectively in activated neurons that express the neural activity marker Fos. However, this method requires pooling samples from many rats. We now describe a modified FACS-based method to characterize molecular alterations in Fos-expressing dorsal striatal neurons from a single rat using a multiplex pre-amplification strategy. Fos and NeuN (a neuronal marker) immunohistochemistry indicate that 5-6% of dorsal striatum neurons were activated 90 min after acute methamphetamine injections (5 mg/kg, i.p.) while less than 0.5% of neurons were activated by saline injections. We used FACS to separate NeuN-labeled neurons into Fos-positive and Fos-negative neurons and assessed mRNA expression using RT-qPCR from as little as five Fos-positive neurons. Methamphetamine induced 3-20-fold increases of immediate early genes arc, homer-2, c-fos, fosB, and its isoforms (ΔfosB and a novel isoform ΔfosB-2) in Fos-positive but not Fos-negative neurons. Immediate early gene mRNA induction was 10-fold lower or absent when assessed in unsorted samples from single dorsal striatum homogenates. Our modified method makes it feasible to study unique molecular alterations in neurons activated by drugs or drug-associated cues in complex addiction models. Methamphetamine and other drugs activate a small proportion of all neurons in the brain. We here report an improved method to characterize molecular alterations induced selectively in activated neurons that express the neural activity marker Fos. We used FACS along with targeted PCR pre-amplification to assess acute methamphetamine-induced gene expression from as few as 5 Fos-expressing neurons from a single rat dorsal striatum. Methamphetamine induced 3-20-fold increases of immediate early genes (IEGs) in Fos-positive but not Fos-negative neurons. Targeted PCR pre-amplification makes it feasible to study unique molecular alterations in neurons activated by drugs or drug-associated cues in complex addiction models.


Assuntos
Corpo Estriado/citologia , Corpo Estriado/metabolismo , Citometria de Fluxo/métodos , Regulação da Expressão Gênica , Metanfetamina/farmacologia , Proteínas Proto-Oncogênicas c-fos/biossíntese , Sequência de Aminoácidos , Animais , Corpo Estriado/efeitos dos fármacos , Masculino , Dados de Sequência Molecular , Proteínas Proto-Oncogênicas c-fos/genética , Ratos , Ratos Sprague-Dawley
8.
Adv Mater ; 36(26): e2403588, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38490170

RESUMO

A low-generation lysine dendrimer, SPr-G2, responds to intracellular glutathione to initiate bioorthogonal in situ polymerization, resulting in the formation of large assemblies in mouse breast cancer cells. The intracellular large assemblies of SPr-G2 can interact with lysosomes to induce lysosome expansion and enhance lysosomal membrane permeabilization, leading to major histocompatibility complex class I upregulation on tumor cell surfaces and ultimately tumor cell death. Moreover, the use of the SPr-G2 dendrimer to conjugate the chemotherapeutic drug, camptothecin (CPT), can boost the therapeutic potency of CPT. Excellent antitumor effects in vitro and in vivo are obtained from the combinational treatment of the SPr-G2 dendrimer and CPT. This combinational effect also enhances antitumor immunity through promoting activation of cytotoxic T cells in tumor tissues and maturation of dendritic cells. This study can shed new light on the development of peptide dendritic agents for cancer therapy.


Assuntos
Apresentação de Antígeno , Dendrímeros , Lisossomos , Polimerização , Lisossomos/metabolismo , Lisossomos/química , Animais , Dendrímeros/química , Camundongos , Linhagem Celular Tumoral , Apresentação de Antígeno/efeitos dos fármacos , Camptotecina/farmacologia , Camptotecina/química , Humanos , Células Dendríticas/efeitos dos fármacos , Células Dendríticas/metabolismo , Antineoplásicos/farmacologia , Antineoplásicos/química
9.
Adv Mater ; 36(25): e2400582, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38477381

RESUMO

The effects of dendron side chains in polymeric conjugates on tumor penetration and antigen presentation are systematically examined. Three polymer-gemcitabine (Gem) conjugates (pG0-Gem, pG1-Gem, pG2-Gem) are designed and prepared. The pG2-Gem conjugate uniquely binds to the mitochondria of tumor cells, thus regulating mitochondrial dynamics. The interaction between the pG2-Gem conjugate and the mitochondria promotes great penetration and accumulation of the conjugate at the tumor site, resulting in pronounced antitumor effects in an animal model. Such encouraging therapeutic effects can be ascribed to immune modulation since MHC-1 antigen presentation is significantly enhanced due to mitochondrial fusion and mitochondrial metabolism alteration after pG2-Gem treatment. Crucially, the drug-free dendronized polymer, pG2, is identified to regulate mitochondrial dynamics, and the regulation is independent of the conjugated Gem. Furthermore, the combination of pG2-Gem with anti-PD-1 antibody results in a remarkable tumor clearance rate of 87.5% and a prolonged survival rate of over 150 days, demonstrating the potential of dendronized polymers as an innovative nanoplatform for metabolic modulation and synergistic tumor immunotherapy.


Assuntos
Desoxicitidina , Gencitabina , Dinâmica Mitocondrial , Nanomedicina , Polímeros , Animais , Nanomedicina/métodos , Humanos , Polímeros/química , Desoxicitidina/análogos & derivados , Desoxicitidina/química , Desoxicitidina/farmacologia , Camundongos , Dinâmica Mitocondrial/efeitos dos fármacos , Dendrímeros/química , Linhagem Celular Tumoral , Imunoterapia , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Mitocôndrias/metabolismo , Mitocôndrias/efeitos dos fármacos , Imunomodulação/efeitos dos fármacos
10.
Adv Sci (Weinh) ; 11(11): e2307154, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38161213

RESUMO

Nanozyme catalytic therapy for cancer treatments has become one of the heated topics, and the therapeutic efficacy is highly correlated with their catalytic efficiency. In this work, three copper-doped CeO2 supports with various structures as well as crystal facets are developed to realize dual enzyme-mimic catalytic activities, that is superoxide dismutase (SOD) to reduce superoxide radicals to H2 O2 and peroxidase (POD) to transform H2 O2 to ∙OH. The wire-shaped CeO2 /Cu-W has the richest surface oxygen vacancies, and a low level of oxygen vacancy (Vo) formation energy, which allows for the elimination of intracellular reactive oxygen spieces (ROS) and continuous transformation to ∙OH with cascade reaction. Moreover, the wire-shaped CeO2 /Cu-W displays the highest toxic ∙OH production capacity in an acidic intracellular environment, inducing breast cancer cell death and pro-apoptotic autophagy. Therefore, wire-shaped CeO2 /Cu nanoparticles as an artificial enzyme system can have great potential in the intervention of intracellular ROS in cancer cells, achieving efficacious nanocatalytic therapy.


Assuntos
Cério , Cobre , Neoplasias , Humanos , Espécies Reativas de Oxigênio/metabolismo , Oxigênio
11.
Nat Commun ; 15(1): 3048, 2024 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-38589497

RESUMO

Flexible pressure sensors can convert mechanical stimuli to electrical signals to interact with the surroundings, mimicking the functionality of the human skins. Piezocapacitive pressure sensors, a class of most widely used devices for artificial skins, however, often suffer from slow response-relaxation speed (tens of milliseconds) and thus fail to detect dynamic stimuli or high-frequency vibrations. Here, we show that the contact-separation behavior of the electrode-dielectric interface is an energy dissipation process that substantially determines the response-relaxation time of the sensors. We thus reduce the response and relaxation time to ~0.04 ms using a bonded microstructured interface that effectively diminishes interfacial friction and energy dissipation. The high response-relaxation speed allows the sensor to detect vibrations over 10 kHz, which enables not only dynamic force detection, but also acoustic applications. This sensor also shows negligible hysteresis to precisely track dynamic stimuli. Our work opens a path that can substantially promote the response-relaxation speed of piezocapacitive pressure sensors into submillisecond range and extend their applications in acoustic range.

12.
Anal Methods ; 15(7): 925-936, 2023 02 16.
Artigo em Inglês | MEDLINE | ID: mdl-36688606

RESUMO

In this study, 3-carboxyphenylboronic acid (CP)-functionalized amino-modified Fe3O4 (Fe3O4@NH2-CP, FNC) magnetic molecularly imprinted polymers (FNC@MIPs) were synthesized and applied for the quick identification and selective separation of luteolin (LTL). The structure and morphology were characterized in detail by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), dynamic light scattering (DLS), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and vibrating specimen magnetometry (VSM) methods. The FNC@MIPs had a homogeneous shape, excellent magnetic characteristics, quick binding kinetics, a high adsorption capacity, acceptable selectivity, and stable reusability. The solid-phase extraction parameters and preparation conditions were both optimized. Under optimized conditions, the maximal adsorption capacity was 14.26 mg g-1 and the imprinting factor was 3.62. Furthermore, the experimental kinetics data were best fitted with the pseudo-first-order model (R2 = 0.9877), and the Langmuir model could describe the adsorption process (R2 = 0.9979), suggesting a monolayer covering. The practical application of the sorbent for LTL detection in Lonicera japonica Thunb samples showed recoveries in the range of 84.5-108.7%. Therefore, the strategy offers a fresh avenue for the extraction and purification of LTL.


Assuntos
Impressão Molecular , Polímeros Molecularmente Impressos , Impressão Molecular/métodos , Luteolina , Polímeros/química , Espectroscopia de Infravermelho com Transformada de Fourier , Fenômenos Magnéticos
13.
J Chromatogr A ; 1705: 464181, 2023 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-37442071

RESUMO

The hollow MCM-48 polyethyleneimine carboxyphenylboronic acid molecularly imprinted polymers (H-MPC@MIPs) were synthesized to efficiently and selectively separate and enrich the ovalbumin (OVA) in egg white samples. Polyethyleneimine contained enough active amino groups to increase the amount of boric acid molecules modified to silica nanoparticles. Meanwhile, the materials were etched to enhance the adsorption effect. The H-MPC@MIPs exhibited a rapid adsorption equilibrium rate (within 30 min) and outstanding adsorption capacity for OVA (1334.1 mg g-1). It possessed a good reusability after 5 cycles. In addition, both the high density and the imprinting action of boric acid were essential for enhancing the identification and binding of OVA. The OVA in egg white samples was successfully selectively enriched using this method.


Assuntos
Impressão Molecular , Nanopartículas , Ovalbumina , Polímeros/química , Polietilenoimina , Nanopartículas/química , Adsorção
14.
Nat Commun ; 14(1): 7121, 2023 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-37963866

RESUMO

Humans can gently slide a finger on the surface of an object and identify it by capturing both static pressure and high-frequency vibrations. Although modern robots integrated with flexible sensors can precisely detect pressure, shear force, and strain, they still perform insufficiently or require multi-sensors to respond to both static and high-frequency physical stimuli during the interaction. Here, we report a real-time artificial sensory system for high-accuracy texture recognition based on a single iontronic slip-sensor, and propose a criterion-spatiotemporal resolution, to corelate the sensing performance with recognition capability. The sensor can respond to both static and dynamic stimuli (0-400 Hz) with a high spatial resolution of 15 µm in spacing and 6 µm in height, together with a high-frequency resolution of 0.02 Hz at 400 Hz, enabling high-precision discrimination of fine surface features. The sensory system integrated on a prosthetic fingertip can identify 20 different commercial textiles with a 100.0% accuracy at a fixed sliding rate and a 98.9% accuracy at random sliding rates. The sensory system is expected to help achieve subtle tactile sensation for robotics and prosthetics, and further be applied to haptic-based virtual reality and beyond.

15.
Materials (Basel) ; 15(12)2022 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-35744111

RESUMO

Post-bond heat treatment (PBHT) is an effective way to improve the bonding quality of a brazed joint. Herein, brazing of a nickel-based single crystal superalloy is carried out using a Ni-Cr-Co-B-Si-Al-Ti-W-Mo filler alloy, and the microstructure and creep property of the brazed joint are systematically investigated using scanning electron microscopy (SEM), Thermo-Calc software, an electron probe micro-analyzer (EPMA), X-ray diffractometer, confocal scanning laser microscope (CSLM), and transmission electron microscopy (TEM). The results reveal that the as-prepared joint only consists of an isothermally solidified zone (ISZ) and an athermally solidified zone (ASZ), where the cubic γ' phase is observed in the ISZ, and skeleton-like M3B2, γ + γ' eutectic and reticular G phases are observed in the ASZ. Furthermore, the γ + γ' eutectic and G phases disappear and the M3B2 alters from a skeleton-like to block-like shape in the ASZ after PBHT. Meanwhile, some lath-like M3B2 phases are precipitated at the edge of the ISZ and several M3B2 phases are precipitated in the base metal, forming a new zone in the brazed joint, namely at the diffusion affected zone (DAZ). Owing to the removal of low melting point eutectics from the as-prepared joint, the creep life also increases from 188 h to 243 h after PBHT. The current work provides a method for the optimization of brazed joints based on the Ni-based single crystal superalloy.

16.
Carbohydr Polym ; 292: 119662, 2022 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-35725165

RESUMO

Rapid development of stimuli-responsive drug delivery systems (DDSs) for tumor therapy has raised increasing interest in recent decades, and many nanomedicines are prepared to achieve accurate or sustained drug release. However, the fabrication process for these nanomedicines has been far too intricate and their potential biosafety has not been fully understood, which has hampered their clinical translation. Challenges for developing DDSs remain on balancing the complexity of the fabrication process with their translational feasibility. Owing to water-solubility, biocompatibility, biodegradability and CD44-targetability, hyaluronic acid (HA) as a versatile building block has gained great popularity due to a simplified fabrication process and unique characteristics of HA for DDSs. In this review, we overviewed the biological function and multiple chemical modifications of HA, and discussed the fabrication of HA-based drug delivery systems (HA-DDSs) with specific tumor microenvironmental stimuli-responsive linkers. We systemically surveyed the applications of HA-DDSs for chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, gene delivery and combination therapy.


Assuntos
Neoplasias , Fotoquimioterapia , Sistemas de Liberação de Medicamentos , Humanos , Ácido Hialurônico/uso terapêutico , Nanomedicina , Neoplasias/tratamento farmacológico , Neoplasias/patologia
17.
ACS Nano ; 16(3): 4338-4347, 2022 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-35234457

RESUMO

Flexible pressure sensors that have high sensitivity, high linearity, and a wide pressure-response range are highly desired in applications of robotic sensation and human health monitoring. The challenge comes from the incompressibility of soft materials and the stiffening of microstructures in the device interfaces that lead to gradually saturated response. Therefore, the signal is nonlinear and pressure-response range is limited. Here, we show an iontronic flexible pressure sensor that can achieve high sensitivity (49.1 kPa-1), linear response (R2 > 0.995) over a broad pressure range (up to 485 kPa) enabled by graded interlocks of an array of hemispheres with fine pillars in the ionic layer. The high linearity comes from the fact that the pillar deformation can compensate for the effect of structural stiffening. The response-relaxation time of the sensor is <5 ms, allowing the device to detect vibration signals with frequencies up to 200 Hz. Our sensor has been used to recognize objects with different weights based on machine learning during the gripper grasping tasks. This work provides a strategy to make flexible pressure sensors that have combined performances of high sensitivity, high linearity, and wide pressure-response range.

18.
Nat Commun ; 13(1): 1317, 2022 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-35273183

RESUMO

Electronic skins (e-skins) are devices that can respond to mechanical stimuli and enable robots to perceive their surroundings. A great challenge for existing e-skins is that they may easily fail under extreme mechanical conditions due to their multilayered architecture with mechanical mismatch and weak adhesion between the interlayers. Here we report a flexible pressure sensor with tough interfaces enabled by two strategies: quasi-homogeneous composition that ensures mechanical match of interlayers, and interlinked microconed interface that results in a high interfacial toughness of 390 J·m-2. The tough interface endows the sensor with exceptional signal stability determined by performing 100,000 cycles of rubbing, and fixing the sensor on a car tread and driving 2.6 km on an asphalt road. The topological interlinks can be further extended to soft robot-sensor integration, enabling a seamless interface between the sensor and robot for highly stable sensing performance during manipulation tasks under complicated mechanical conditions.

19.
Pain Res Manag ; 2021: 3788660, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34956432

RESUMO

Cracked tooth syndrome refers to a series of symptoms caused by cracked teeth. This article reviews the current literature on cracked tooth syndrome from four aspects, etiology, diagnosis, management, and prevention, to provide readers integrated information about this. The article begins with an introduction to the odontiatrogenic factors and then covers the noniatrogenic factors that induce cracked tooth syndrome. While the former discusses inappropriate root canal therapy and improper restorative procedures, the latter covers the topics such as the developmental and functional status of cracked tooth syndrome. This is then followed by the description of common clinical diagnosis methods, the prospects of new technologies, and summaries of current clinical management methods, including immediate management and direct and indirect restoration. In the final section, preventive methods and their importance are proposed, with the aim of educating the common population.


Assuntos
Síndrome de Dente Quebrado , Síndrome de Dente Quebrado/diagnóstico , Síndrome de Dente Quebrado/etiologia , Síndrome de Dente Quebrado/terapia , Assistência Odontológica , Humanos , Tratamento do Canal Radicular
20.
Scanning ; 2021: 9950131, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34367410

RESUMO

Three-dimensional (3D) printing technologies are advanced manufacturing technologies based on computer-aided design digital models to create personalized 3D objects automatically. They have been widely used in the industry, design, engineering, and manufacturing fields for nearly 30 years. Three-dimensional printing has many advantages in process engineering, with applications in dentistry ranging from the field of prosthodontics, oral and maxillofacial surgery, and oral implantology to orthodontics, endodontics, and periodontology. This review provides a practical and scientific overview of 3D printing technologies. First, it introduces current 3D printing technologies, including powder bed fusion, photopolymerization molding, and fused deposition modeling. Additionally, it introduces various factors affecting 3D printing metrics, such as mechanical properties and accuracy. The final section presents a summary of the clinical applications of 3D printing in dentistry, including manufacturing working models and main applications in the fields of prosthodontics, oral and maxillofacial surgery, and oral implantology. The 3D printing technologies have the advantages of high material utilization and the ability to manufacture a single complex geometry; nevertheless, they have the disadvantages of high cost and time-consuming postprocessing. The development of new materials and technologies will be the future trend of 3D printing in dentistry, and there is no denying that 3D printing will have a bright future.


Assuntos
Desenho Assistido por Computador , Impressão Tridimensional , Odontologia
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