1.
Org Lett
; 24(5): 1247-1252, 2022 02 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35112872
RESUMO
An appealing and challenging cage structure along with an unusual biosynthetic pathway prompted us to explore an expeditious bioinspired one-pot total synthesis of nesteretal A. An unconventional strategy was chosen, and a cascade reaction starting from diacetyl was studied. Under organocatalytic conditions mimicking an aldolase, nesteretal A and a related cage analogue were anticipated by in silico metabolization, detected, targeted, and characterized.