Detalhe da pesquisa
1.
Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial.
Blood
; 141(11): 1265-1276, 2023 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36265087
2.
Venetoclax in biomarker-selected multiple myeloma patients: Impact of exposure on clinical efficacy and safety.
Hematol Oncol
; 42(1): e3222, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37740931
3.
Venetoclax pharmacokinetics in participants with end-stage renal disease undergoing haemodialysis.
Br J Clin Pharmacol
; 90(3): 748-758, 2024 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37855131
4.
Effect of isotretinoin on CYP2D6 and CYP3A activity in patients with severe acne.
Br J Clin Pharmacol
; 90(3): 759-768, 2024 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37864393
5.
CYP2D6 Activity Is Correlated with Changes in Plasma Concentrations of Taurocholic Acid during Pregnancy and Postpartum in CYP2D6 Extensive Metabolizers.
Drug Metab Dispos
; 51(11): 1474-1482, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37550070
6.
Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease.
Pharm Res
; 40(11): 2597-2606, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37704895
7.
Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
FASEB J
; 34(12): 15788-15804, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33105029
8.
The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance.
J Biol Chem
; 294(29): 11166-11179, 2019 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31167781
9.
Sampling Site Has a Critical Impact on Physiologically Based Pharmacokinetic Modeling.
J Pharmacol Exp Ther
; 372(1): 30-45, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31604807
10.
Mechanistic PBPK Modeling of Urine pH Effect on Renal and Systemic Disposition of Methamphetamine and Amphetamine.
J Pharmacol Exp Ther
; 373(3): 488-501, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32198137
11.
Physiologically Based Pharmacokinetic Model of the CYP2D6 Probe Atomoxetine: Extrapolation to Special Populations and Drug-Drug Interactions.
Drug Metab Dispos
; 45(11): 1156-1165, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28860113
12.
Predicting complex kidney drug handling using a physiologically-based pharmacokinetic model informed by biomarker-estimated secretory clearance and blood flow.
Clin Transl Sci
; 17(1): e13678, 2024 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37921258
13.
"Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy".
NPJ Syst Biol Appl
; 10(1): 11, 2024 Jan 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38278838
14.
Venetoclax and Cobimetinib in Relapsed/Refractory AML: A Phase 1b Trial.
Clin Lymphoma Myeloma Leuk
; 2024 Jan 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38378362
15.
Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer.
Prostate
; 73(12): 1352-63, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23661607
16.
Impact of Pregnancy and Vitamin A Supplementation on CYP2D6 Activity.
J Clin Pharmacol
; 63(3): 363-372, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36309846
17.
Clinical Pharmacology Perspectives for Adoptive Cell Therapies in Oncology.
Clin Pharmacol Ther
; 112(5): 968-981, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34888856
18.
Objective Identification of Cannabis Use Levels in Clinical Populations Is Critical for Detecting Pharmacological Outcomes.
Cannabis Cannabinoid Res
; 7(6): 852-864, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34793254
19.
Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors.
Front Pharmacol
; 13: 974423, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36225583
20.
Population Pharmacokinetics and Exposure-Response Analyses for Venetoclax in Combination with R-CHOP in Relapsed/Refractory and Previously Untreated Patients with Diffuse Large B Cell Lymphoma.
Adv Ther
; 39(1): 598-618, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34822104