Detalhe da pesquisa
1.
Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis.
J Transl Med
; 22(1): 287, 2024 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38493183
2.
Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
J Transl Med
; 22(1): 218, 2024 Feb 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38424643
3.
Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs.
Mol Ther
; 26(5): 1313-1326, 2018 05 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29680697
4.
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Bioorg Med Chem Lett
; 28(15): 2605-2610, 2018 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29970308
5.
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.
Bioorg Med Chem Lett
; 27(11): 2432-2438, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28427814
6.
Structure-based design, synthesis and biological evaluation of novel ß-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
Bioorg Med Chem Lett
; 25(3): 668-72, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25537272
7.
Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP).
Biochim Biophys Acta
; 1833(6): 1562-71, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23517619
8.
Serum metabolomics study for acute attack of chronic pancreatitis.
Clin Chim Acta
; 541: 117251, 2023 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36775008
9.
Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.
FASEB J
; 25(2): 775-84, 2011 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-21059748
10.
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent ß-secretase inhibitors.
Bioorg Med Chem Lett
; 22(17): 5460-5, 2012 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22863204
11.
Enhanced sucrose-mediated cryoprotection of siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles.
Colloids Surf B Biointerfaces
; 220: 112880, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-36240574
12.
Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis.
J Inflamm Res
; 14: 7381-7392, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34992424
13.
Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus.
PLoS One
; 16(1): e0243903, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33411811
14.
Comprehensive Design of the High-Sulfur-Loading Li-S Battery Based on MXene Nanosheets.
Nanomicro Lett
; 12(1): 112, 2020 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34138112
15.
Highly Selective and Potent Human ß-Secretaseâ 2 (BACE2) Inhibitors against Typeâ 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies.
ChemMedChem
; 14(5): 545-560, 2019 03 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30637955
16.
Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization.
FASEB J
; 21(12): 3184-96, 2007 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-17494994
17.
Design of Potent and Highly Selective Inhibitors for Human ß-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.
Chem Sci
; 7: 3117-3122, 2016 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27347366
18.
Structure-based design of highly selective ß-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
J Med Chem
; 55(21): 9195-207, 2012 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-22954357
19.
Activation profiles of the zymogen of aspergilloglutamic peptidase.
Biol Chem
; 388(1): 129-33, 2007 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-17214557
20.
Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications.
Acta Biochim Biophys Sin (Shanghai)
; 36(12): 787-92, 2004 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-15592644