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To explore the mechanism of Suanzaoren Decoction in the treatment of insomnia from endogenous bile acid regulation, the present study investigated the hepatoprotective effect of Suanzaoren Decoction and the molecular changes of bile acids in the serum, liver, and ileum of insomnia model mice and Suanzaoren Decoction treated mice. The insomnia model in mice was established by the sleep deprivation method. After Suanzaoren Decoction(48.96 mg·kg~(-1)·d~(-1)) intervention by gavage for 7 days, the related indicators, such as water consumption, food intake, body weight, aspartate aminotransferase(AST), alanine transaminase(ALT), and total bile acid(TBA) were detected, and the pathological changes of the liver and ileum were observed. The molecular levels and distribution of 23 bile acids in the serum, liver, and ileum were analyzed by UPLC-MS/MS combined with principal component analysis(PCA) and partial least squares discriminant analysis(PLS-DA). The results showed that Suanzaoren Decoction could improve the decreased water consumption and food intake, weight loss, and increased AST and ALT in the model group, and effectively reverse the injury and inflammation in the liver and ileum. The bile acids in the liver of the insomnia model mice were in the stage of decompensation, and the bile acids in the serum, liver, and ileum of the mice decreased or increased. Suanzaoren Decoction could regulate the anomaly of some bile acids back to normal. Seven bile acids including glycoursodeoxycholic acid(GUDCA), glycodesoxycholic acid(GDCA), tauro-α-MCA(T-α-MCA), α-MCA, taurodeoxycholate(TDCA), T-ß-MCA, and LCA were screened out as the main discriminant components by PLS-DA. It is concluded that Suanzaoren Decoction possesses the hepatoprotective effect and bile acids could serve as the biochemical indicators to evaluate the drug efficacy in the treatment of abnormal liver functions caused by insomnia. The mechanism of Suanzao-ren Decoction in soothing the liver, resolving depression, tranquilizing the mind, and improving sleep may be related to the molecular regulation of bile acid signals.
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Ácidos e Sais Biliares , Distúrbios do Início e da Manutenção do Sono , Animais , Cromatografia Líquida , Medicamentos de Ervas Chinesas , Íleo , Fígado , Camundongos , Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico , Espectrometria de Massas em TandemRESUMO
High efficiency and good stability are the challenges for perovskite solar cells (PSCs) toward commercialization. However, the intrinsic high defect density and internal nonradiative recombination of perovskite (PVK) limit its development. In this work, a facile additive strategy is devised by introducing bifunctional guanidine sulfamate (GuaSM; CH6 N3 + , Gua+ ; H2 N-SO3 - , SM- ) into PVK. The size of Gua+ ion is suitable with Pb(BrI)2 cavity relatively, so it can participate in the formation of low-dimensional PVK when mixed with Pb(BrI)2 . The O and N atoms of SM- can coordinate with Pb2+ . The synergistic effect of the anions and cations effectively reduces the trap density and the recombination in PVK, so that it can improve the efficiency and stability of PSCs. At an optimal concentration of GuaSM (2 mol%), the PSC presents a champion power conversion efficiency of 21.66% and a remarkably improved stability and hysteresis. The results provide a novel strategy for highly efficient and stable PSCs by bifunctional additive.
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Jiao-Tai-Wan, which is composed of Coptis Rhizoma and Cinnamon Cortex, has been recently used to treat type 2 diabetes. Owing to lack of data on its prototypes and metabolites, elucidation of the pharmacological and clinically safe levels of this formula has been significantly hindered. To screen more potential bioactive components of Jiao-Tai-Wan, we identified its multiple prototypes and metabolites in the plasma of type 2 diabetic rats by ultra high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. A total of 47 compounds were identified in the plasma of type 2 diabetic rats, including 22 prototypes and 25 metabolites, with alkaloids constituting the majority of the absorbed prototype components. In addition, this is the first study to detect vanillic acid, gallic acid, chlorogenic acid, protocatechuic acid, 2-hydroxycinnamic acid, 3-hydroxycinnamic acid, 4-hydroxycinnamic acid, and 2-methoxy cinnamic acid after oral administration of Jiao-Tai-Wan. The prototypes from Jiao-Tai-Wan were extensively metabolized by demethylation, hydroxylation, and reduction in phase â metabolic reactions and by methylation or conjugation of glucuronide or sulfate in phase â ¡ reactions. This is the first systematic study on the components and metabolic profiles of Jiao-Tai-Wan in vivo. This study provides a useful chemical basis for further pharmacological research and clinical application of Jiao-Tai-Wan.
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Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Tipo 2/sangue , Medicamentos de Ervas Chinesas/análise , Administração Oral , Animais , Cromatografia Líquida de Alta Pressão , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Medicamentos de Ervas Chinesas/administração & dosagem , Teste de Tolerância a Glucose , Masculino , Espectrometria de Massas , Ratos , Ratos Sprague-Dawley , Fatores de TempoRESUMO
To explore the pathogenesis of heart and kidney imbalance insomnia and the regulatory effect of Jiaotai Pills, in order to study the changes of central and peripheral neurotransmitters in rat. Insomnia rats with heart and kidney imbalance were induced through intraperitoneal injection with p-chlorophenylalanine(PCPA, 400 mg·kg~(-1)·d~(-1)), and the model rats were intragastrically administrated with Jiaotai Pills(3.3 g·kg~(-1)·d~(-1)) for 7 days. Nine neurotransmitters were determined by UPLC-MS/MS and principal component analysis(PCA) method in serum, urine, brain, heart, liver, kidney and adrenal gland of rats. The results showed that the ratio of 5-HT and 5-HIAA in platelet of insomnia rats was significantly lower than that in the normal group, and Jiaotai Pills had a significant up-regulatory or down-regulatory effect. Compared with the normal group, the changed neurotransmitters in blood of insomnia rats were 5-HIAA, E, NE, DA, Glu and ACH, and except ACH, the changes of 7 kinds of neurotransmitters in urine were more significant, Jiaotai Pills had a significant up-regulatory or down-regulatory effect. Compared with the normal group, all of the 8 neurotransmitters in insomnia rats except HVA were changed. Jiaotai Pills could regulate the neurotransmitters in each tissue of insomnia rats, especially in brain, liver and adrenal gland. In conclusion, insomnia is caused by not only a change of neurotransmitters in brain, but also a series of changes in peripheral tissues. It indicates that insomnia is a systematic imbalance of neurotransmitters. Jiaotai Pills not only regulates the central nervous system, but also has a certain protective effect on other organs, reflecting the multi-target and systematic effect of Jiaotai Pills in the treatment of insomnia.
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Distúrbios do Início e da Manutenção do Sono , Animais , Cromatografia Líquida , Medicamentos de Ervas Chinesas , Neurotransmissores , Ratos , Espectrometria de Massas em TandemRESUMO
Ultra performance liquid chromatography-tandem mass spectrometry( UPLC-MS/MS) was used to establish the simultaneous determination method of eight neurotransmitters in brain,liver,kidney,adrenal gland,serum and urine,including serotonin,5-hydroxyindole acetic acid,epinephrine,norepinephrine,dopamine,glutamic acid,γ-aminobutyric acid,and acetylcholine,and then investigate the distribution characteristics of neurotransmitters in rat tissues,blood and urine. Waters ACQUITY UPLC BEH C_(18) column( 2. 1 mm×100 mm,1. 7 µm) was used,with 0. 3% formic acid solution-acetonitrile as the mobile phase for gradient elution.Multiple reaction monitoring( MRM) scanning method under positive mode by atmospheric pressure electrospray ion source( ESI) was also performed to establish the detection method of neurotransmitters for methodological research. The plasma,urine and tissues of normal rats were pre-treated including homogenization,centrifuging,and protein removal,then the 2 µL supernatant was injected for analysis. The results showed that eight kinds of neurotransmitters could be accurately determined within 7 min,with linear correlation coefficients all greater than 0. 99. This method showed high accuracy and good precision,with specificity,stability,extraction recovery and matrix effects all complying with the biological sample analysis requirements. The most abundant transmitters in the brain,liver,kidney,kidney gland,blood and urine were γ-aminobutyric acid,glutamic acid,glutamic acid,adrenaline,glutamic acid and dopamine.The method is sensitive,rapid,precise,accurate and specific,and can be used for simultaneous quantitative analysis of eight neurotransmitters in biological samples. The investigation of the distribution ratio of transmitters in rats is of important significance to disease prevention and treatment.
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Neurotransmissores/metabolismo , Espectrometria de Massas em Tandem , Animais , Cromatografia Líquida de Alta Pressão , Cromatografia Líquida , Neurotransmissores/sangue , Neurotransmissores/urina , Ratos , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
Dye-sensitized solar cells (DSSCs) are regarded as prospective solar cells for the next generation of photovoltaic technologies and have become research hotspots in the PV field. The counter electrode, as a crucial component of DSSCs, collects electrons from the external circuit and catalyzes the redox reduction in the electrolyte, which has a significant influence on the photovoltaic performance, long-term stability and cost of the devices. Solar cells, dye-sensitized solar cells, as well as the structure, principle, preparation and characterization of counter electrodes are mentioned in the introduction section. The next six sections discuss the counter electrodes based on transparency and flexibility, metals and alloys, carbon materials, conductive polymers, transition metal compounds, and hybrids, respectively. The special features and performance, advantages and disadvantages, preparation, characterization, mechanisms, important events and development histories of various counter electrodes are presented. In the eighth section, the development of counter electrodes is summarized with an outlook. This article panoramically reviews the counter electrodes in DSSCs, which is of great significance for enhancing the development levels of DSSCs and other photoelectrochemical devices.
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Particulate solid solutions Bi(1-x)Ni(x)VO(4-y) were synthesized by solid-state reaction at high temperature. The samples were characterized by X-ray Diffraction (XRD), Field-Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive Spectrometer (EDS), Brunauer-Emmett-Teller (BET) surface area and Ultraviolet-Visible spectroscopy (UV-Vis). The photocatalytic activity of BiVO4 for photocatalytic degradation of organic contaminants ability in visible light region could be improved by doping of Ni(2+). The high visible light photocatalytic activity of Bi(1-x)Ni(x)VO(4-y) solid solution might be due to the generation of a new band gap and expanding the range of visible light response. It was suggested that the Ni(2+) doping was beneficial to effective charge separation of Bi(1-x)Ni(x)VO(4-y) solid solution, thus improved the photocatalytic activity.
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Compostos Azo/análise , Bismuto/química , Níquel/química , Fotólise , Vanadatos/química , Compostos Azo/química , LuzRESUMO
Background: Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus (DM), being the second cause of end-stage renal disease globally. Podocyte injury is closely associated with DN developmen. Our study aimed to investigate the role of long non-coding RNA (lncRNA) TTN-AS1 in DN-associated podocyte injury. Methods: The mouse podocyte cell line (MPC5) and human primary podocytes were stimulated by high glucose (HG; 30 nM glucose) to establish the cellular model of DN. Before HG stimulation, both podocytes were transfected with sh-TTN-AS1#1/2 or pcDNA3.1/STAT3 to evaluate the influence of TTN-AS1 knockdown or STAT3 overexpression on HG-induced podocyte injury. TTN-AS1 and STAT3 expression in both podocytes was examined by RT-qPCR. Cell viability and death were assessed by CCK-8 and LDH release assay. ELISA was adopted for testing IL-6 and TNF-α contents in cell supernatants. The levels of oxidative stress markers (ROS, MDA, SOD, and GSH) in cell supernatants were determined by commercial kits. Western blotting was used for measuring the expression of fibrosis markers (fibronectin and α-SMA and podocyte function markers (podocin and nephrin) in podocytes. Results: HG stimulation led to decreased cell viability, increased cell death, fibrosis, inflammation, cell dysfunction and oxidative stress in podocytes. However, knockdown of TTN-AS1 ameliorated HG-induced podocyte injury. Mechanically, the transcription factor STAT3 interacted with TTN-AS1 promoter and upregulated TTN-AS1 expression. STAT3 overexpression offset the protective effect of TTN-AS1 silencing on HG-induced podocyte damage. Conclusion: Overall, STAT3-mediated upregulation of lncRNA TTN-AS1 could exacerbate podocyte injury in DN through suppressing inflammation and oxidative stress.
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Lithium ion capacitors (LICs) are a new generation of energy storage devices that combine the super energy storage capability of lithium ion batteries with the satisfactory power density of supercapacitors. The development of high-performance LICs still faces great challenges due to the unbalanced reaction kinetics at the anode and cathode. Therefore, it is an inevitable need to enhance the electron/ion transfer capability of the anode materials. In this paper, to obtain a superior-rate and high-capacity Ni3S2-based anode, highly conductive Ti3C2Tx MXene sheets were introduced to sever as the carrier of Ni3S2 nanoparticles and simultaneously an amorphous carbon layer which coats onto the surface of Ni3S2 nanoparticles was in-situ generated by the carbonization of dopamine reactant. The as-synthesized Ni3S2/Ti3C2Tx/C composite exhibits a high specific surface area (112.6 m2/g) because of the addition of Ti3C2Tx that can reduce the aggregation of Ni3S2 nanoparticles and the in-situ generated amorphous carbon layer that can suppress the growth of Ni3S2 nanoparticles. The Ni3S2/Ti3C2Tx/C anode possesses a remarkable reversible discharge specific capacity (626.0 mAh/g under 0.2 A/g current density), which increases to 1150.8 mAh/g after 400-cycle charge/discharge measurement at the same measurement condition indicating eminent cyclability, along with superior rate capability. To construct a superior-performance LIC device, a sterculiae lychnophorae derived porous carbon (SLPC) cathode with an average discharge specific capacity of 73.4 mAh/g@0.1A/g was prepared. The Ni3S2/Ti3C2Tx/C//SLPC LIC device with optimal cathode/anode mass ratio has a satisfactory energy density ranging from 32.8 to 119.1 Wh kg-1 at the corresponding power density of 8799.4 to 157.5 W kg-1, together with a prominent capacity retention (95.5 %@1 A/g after 10,000 cycles).
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The best research-cell efficiency of perovskite solar cells (PSCs) is comparable with that of mature silicon solar cells (SSCs); However, the industrial development of PSCs lags far behind SSCs. PSC is a multiphase and multicomponent system, whose consequent interfacial energy loss and carrier loss seriously affect the performance and stability of devices. Here, by using spinodal decomposition, a spontaneous solid phase segregation process, in situ introduces a poly(3-hexylthiophene)/perovskite (P3HT/PVK) heterointerface with interpenetrating structure in PSCs. The P3HT/PVK heterointerface tunes the energy alignment, thereby reducing the energy loss at the interface; The P3HT/PVK interpenetrating structure bridges a transport channel, thus decreasing the carrier loss at the interface. The simultaneous mitigation of energy and carrier losses by P3HT/PVK heterointerface enables n-i-p geometry device a power conversion efficiency of 24.53% (certified 23.94%) and excellent stability. These findings demonstrate an ingenious strategy to optimize the performance of PSCs by heterointerface via Spinodal decomposition.
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At present, the research of safety science discipline is limited to the level of describing psychology and behaviors, because the cognitive neural mechanisms behind them are unknown. This paper introduces an emerging interdiscipline, namely neuro-safety science, which uses the neuroscientific methods to investigate the neural systems behind safely relevant behaviors. Qualitative methods such as literature review method and theoretical model construction method were adopted for this study. Based on the background of neuro-safety science, the definition of neuro-safety science was defined, its connotation was analyzed, and the research contents from two aspects of theoretical research and practical application research were proposed. Methodology system including research principles, research routes, research procedure and research methods, and the paradigm system of neuro-safety science were put forward. At last, the application research on neuro-safety science was forecasted. This paper opens up a new research perspective for the research of safety science, and provide guidance and reference to develop neuro-safety science.
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Diabetic nephropathy (DN), a common cause of chronic renal failure and end-stage renal disease, leads to a high mortality. However, the role of TTN-AS1 in extracellular matrix (ECM) accumulation during DN remains unclear. In our study, TTN-AS1 exhibited high expression in high glucose-treated mesangial cells, and TTN-AS1 silencing alleviated high glucose-induced ECM accumulation in mesangial cells. Additionally, animal study revealed that TTN-AS1 was upregulated in renal tissues of DN rats, and TTN-AS1 knockdown mitigated renal injury of DN rats. Mechanistically, TTN-AS1 was validated to bind to miR-493-3p, and miR-493-3p targeted forkhead box P2 (FOXP2) 3'untranslated region in mesangial cells. TTN-AS1 interacted with miR-493-3p to upregulate FOXP2 in vitro and in vivo. Moreover, FOXP2 overexpression counteracted the effects of TTN-AS1 silencing on the ECM accumulation. In conclusion, TTN-AS1 exacerbated ECM accumulation via the miR-493-3p/FOXP2 axis during DN development. This research may provide a potential new direction for DN treatment.
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Diabetes Mellitus , Nefropatias Diabéticas , MicroRNAs , RNA Longo não Codificante , Animais , Ratos , Nefropatias Diabéticas/genética , RNA Longo não Codificante/genética , Matriz Extracelular , Glucose , MicroRNAs/genética , Fatores de Transcrição Forkhead/genética , ConectinaRESUMO
Ternary metal sulfides employed in supercapacitors exhibit better electrochemical performances than their counterpart oxides due to their superior conductivity. However, the insertion/extraction of electrolyte ions can lead to a significant volume change in electrode materials, which can result in poor cycling stability. Herein, novel amorphous Co-Mo-S nanospheres were fabricated through a facile room-temperature vulcanization method. It involves the conversion of crystalline CoMoO4 by reacting it with Na2S at room temperature. In addition to the conversion of the crystalline state into an amorphous structure with more grain boundaries, which is beneficial for the transport of electron/ion and can accommodate the volume change generated by the insertion/extraction of electrolyte ions, the production of more pores led to an increased specific surface area. The electrochemical results indicate that the as-prepared amorphous Co-Mo-S nanospheres had a specific capacitance of up to 2049.7F/g@1 A/g together with good rate capability. The amorphous Co-Mo-S nanospheres can be used as the cathode of supercapacitors and assembled with an activated carbon anode into an asymmetric supercapacitor possessing a satisfactory energy density of 47.6 Wh kg-1@1012.9 W kg-1. One of the prominent features exhibited by this asymmetric device is its remarkable cyclic stability, with a capacitance retention of 107% after 10,000 cycles.
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The rapid development of perovskite solar cells (PSCs) makes it one of the most competitive photovoltaic devices in the field of new energy. However, the suboptimal performance and poor stability caused by numerous defects are still the main factors limiting the development of PSCs. Herein, a polarized molecule additive of 4-(aminomethyl) benzonitrile hydrochloride (AMBNCl) is introduced into perovskite. Owing to its special polar electron density distribution, -C≡N group, -NH3+ terminal, and Cl- ions, the modification of AMBNCl can improve the quality of perovskite crystal growth, passivate the defects of Pb2+, adjust the energy level array between the perovskite layer and hole-transport layer, and alleviate the carrier nonradiative recombination. As a result, the AMBNCl-modified device achieves a champion efficiency of 23.52%. The unpacked device still maintained 91.2% of its original efficiency after storing in an air environment (RH â¼40%, 25 °C) for 50 days.
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W(18)O(49) nanorods were synthesized by pyrolyzing (NH(4))(x)WO(3+x/2) nanorods precursors, which were prepared by a hydrothermal reaction using sulfate as a structure-directing agent, in a reductive atmosphere of H(2)(5 vol %)/N(2) at 500 °C for 1 h. W(18)O(49) nanorods showed high transmittance in the visible region as well as excellent shielding properties of NIR lights. A simulated experiment revealed that excellent heat insulating performance can be realized by applying a 70% visible light transparent W(18)O(49) coating on a quartz glass. Meanwhile, the W(18)O(49) nanorods also showed strong absorption of NIR light and instantaneous conversion of photoenergy to heat. In a word, W(18)O(49) nanorods hold interesting optical properties and are a promising material in a wide range of applications.
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The convenience of "no installation, available at your fingertips" of the WeChat small program makes it unique in the application of mobile terminal auxiliary experimental teaching. In order to optimize the assessment system and improve the quality and outcomes of experimental teaching, a self-designed WeChat small program was used to assist the development of the process assessment system. This system was applied to the teaching practice of "Experiment of Inorganic Chemistry" course for the first-year undergraduates majored in Biological Engineering, with the aim to promote teaching and learning by assessment. The results showed that course scores of the students who used this small program were superior to the control group and the correlation between the process assessment and final examination results was significant. These results indicated the WeChat small program assisted process assessment could effectively improve the learning outcomes of students, enable them to grasp the knowledge of Experiment of Inorganic Chemistry efficiently. The results of the questionnaire for the teachers and students also showed a high recognition of the WeChat small program assisted teaching.
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Avaliação de Processos em Cuidados de Saúde , Estudantes , Bioengenharia , Química Inorgânica , Humanos , AprendizagemRESUMO
The 2D/3D composite structure possesses both the excellent stability of 2D perovskite and the excellent performance of 3D perovskite, which recently have attracted special attention. Different from the popular isopropanol, a novel additive solvent-polypropylene glycol bis (2-aminopropyl ether) (A-PPG) is introduced here to dissolve excess PbI2 and perovskite, and then reconstruct and in situ form the quasi-2D perovskite layer on 3D perovskite bulk. The lone electron pairs of the ether-oxygen and amino in A-PPG can form coordination bonds with Pb2+ . The introduction of A-PPG tunes the energy array of functional layers, passivates defects, and mitigates carrier nonradiative recombination. Consequently, the 2D/3D perovskite device exhibits a championship efficiency of 22.24% with a distinguished open-circuit voltage of 1.21 V (the thermodynamic limit of 1.30 V). Moreover, the 2D/3D device still maintains 90% of the original efficiency in the ambient atmosphere with a relative humidity of 30 ± 10% after 50 days.
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OBJECTIVE: To reveal the effect and mechanism of Jiaotai Pill (, JTP) on insomniac rats. METHODS: The insomniac model was established by intraperitoneal injection of p-chlorophenylalanine (PCPA). In behavioral experiments, rats were divided into control, insomniac model, JTP [3.3 g/(kgâ¢d)], and diazepam [4 mg/(kgâ¢d)] groups. The treatment effect of JTP was evaluated by weight measurement (increasement of body weight), open field test (number of crossings) and forced swimming test (immobility time). A high performance liquid chromatography-electrochemical detection (HPLC-ECD) method was built to determine the concentration of monoamine transmitters in hypothalamus and peripheral organs from normal, model, JTP, citalopram [30 mg/(kgâ¢d)], maprotiline [40 mg/(kgâ¢d)] and bupropion [40 mg/(kgâ¢d)] groups. Expressions of serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET) were analyzed by quantitative polymerase chain reaction (qPCR) and Western blot in normal, model and JTP groups. A high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS/MS) method was established to determine the pharmacokinetics, urine cumulative excretion of metformin in vivo, and tissue slice uptake in vitro, which were applied to assess the activity of organic cation transporters (OCTs) in hypothalamus and peripheral organs. RESULTS: Compared with the insomniac model group, the body weight and spontaneous locomotor were increased, and the immobility time was decreased after treatment with JTP (P<0.01). Both serotonin and dopamine contents in hypothalamus and peripheral organs were increased (P<0.01). The norepinephrine content was increased in peripheral organs and decreased in hypothalamus (P<0.05 or P<0.01). At the same time, SERT, DAT, OCT1, OCT2, and OCT3 were down-regulated in hypothalamus and peripheral organs (P<0.05). NET was down-regulated in peripheral organs and up-regulated in hypothalamus (P<0.05 or P<0.01). Moreover, the activity of OCTs in hypothalamus and peripheral organs was inhibited (P<0.05). CONCLUSION: JTP alleviates insomnia through regulation of monoaminergic system and OCTs in hypothalamus and peripheral organs.
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Medicamentos de Ervas Chinesas , Distúrbios do Início e da Manutenção do Sono , Animais , Proteínas de Transporte de Cátions , Cátions , Ratos , Espectrometria de Massas em TandemRESUMO
TiO(2):Eu(3+) nanorods are hydrothermally grown and used to fabricate a bilayer film electrode in a dye-sensitized solar cell. A light-to-electrical energy conversion efficiency of 8.0% and a quantum efficiency of 93.7% (at 575 nm) is achieved in this solar cell. The high efficiency is due to the improvement of ultraviolet light harvesting via a down-conversion luminescence process by the Eu(3+) ion and the increase of light scattering by one-dimensional TiO(2).