Detalhe da pesquisa
1.
Explaining in-vitro to in-vivo efficacy correlations in oncology pre-clinical development via a semi-mechanistic mathematical model.
J Pharmacokinet Pharmacodyn
; 51(2): 169-185, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-37930506
2.
Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice.
Am J Respir Cell Mol Biol
; 69(4): 422-440, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37411041
3.
Antifibrotic Drug Nintedanib Inhibits CSF1R to Promote IL-4-associated Tissue Repair Macrophages.
Am J Respir Cell Mol Biol
; 68(4): 366-380, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36227799
4.
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.
J Biol Chem
; 293(18): 6762-6775, 2018 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29559558
5.
Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling.
Cell Commun Signal
; 17(1): 46, 2019 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-31101051
6.
Signal transduction analysis of the NLRP3-inflammasome pathway after cellular damage and its paracrine regulation.
J Theor Biol
; 415: 125-136, 2017 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-28017802
7.
Identifying differential miR and gene consensus patterns in peripheral blood of patients with cardiovascular diseases from literature data.
BMC Cardiovasc Disord
; 17(1): 173, 2017 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-28666417
8.
Modelling tumour cell proliferation from vascular structure using tissue decomposition into avascular elements.
J Theor Biol
; 402: 129-43, 2016 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27155046
9.
Exosomes: emerging roles in communication between blood cells and vascular tissues during atherosclerosis.
Curr Opin Lipidol
; 26(5): 412-9, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26309202
10.
Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.
J Neurosci
; 34(31): 10192-205, 2014 Jul 30.
Artigo
Inglês
| MEDLINE | ID: mdl-25080581
11.
Equilibria and stability of a class of positive feedback loops.
J Math Biol
; 68(3): 609-45, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23358701
12.
Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.
J Biol Chem
; 287(18): 14402-11, 2012 Apr 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22408249
13.
Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.
J Biol Chem
; 287(49): 41546-59, 2012 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-23038270
14.
Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation.
PLoS Comput Biol
; 8(6): e1002565, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22719244
15.
Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.
Gut
; 61(5): 725-33, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22082587
16.
Radius additivity score: a novel combination index for tumour growth inhibition in fixed-dose xenograft studies.
Front Pharmacol
; 14: 1272058, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37900154
17.
Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells.
Elife
; 122023 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-37732732
18.
Mathematical modelling of the mitochondrial apoptosis pathway.
Biochim Biophys Acta
; 1813(4): 608-15, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20950651
19.
Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.
Mol Syst Biol
; 7: 470, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21364572
20.
Positive feedback in the Akt/mTOR pathway and its implications for growth signal progression in skeletal muscle cells: an analytical study.
J Theor Biol
; 301: 15-27, 2012 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22314407