Detalhe da pesquisa
1.
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Cell
; 168(1-2): 86-100.e15, 2017 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27916275
2.
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Nat Immunol
; 17(12): 1361-1372, 2016 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-27798618
3.
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Bioorg Med Chem Lett
; 98: 129546, 2024 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37944866
4.
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
EMBO J
; 37(17)2018 09 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30026309
5.
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.
Biol Chem
; 403(4): 391-402, 2022 03 28.
Artigo
Inglês
| MEDLINE | ID: mdl-35191283
6.
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Br J Cancer
; 124(4): 817-830, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33214684
7.
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.
Chembiochem
; 22(12): 2116-2123, 2021 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33887086
8.
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat Chem Biol
; 15(8): 822-829, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31285596
9.
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Nature
; 519(7544): 477-81, 2015 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25561175
10.
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Nature
; 508(7495): 222-7, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24695225
11.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
J Am Chem Soc
; 141(22): 8951-8968, 2019 06 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31060360
12.
Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor.
Int J Med Microbiol
; 309(2): 130-142, 2019 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-30665874
13.
Global survey of the immunomodulatory potential of common drugs.
Nat Chem Biol
; 13(6): 681-690, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28437395
14.
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Angew Chem Int Ed Engl
; 58(2): 515-519, 2019 01 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30431220
15.
Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.
Nat Methods
; 12(11): 1055-7, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26389571
16.
Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.
Nat Chem Biol
; 12(7): 504-10, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27159579
17.
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew Chem Int Ed Engl
; 57(50): 16302-16307, 2018 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30288907
18.
KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis.
Apoptosis
; 22(9): 1169-1188, 2017 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-28685254
19.
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Nat Chem Biol
; 11(8): 571-578, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26167872
20.
Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
Bioorg Med Chem
; 25(9): 2657-2665, 2017 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28341403