Precision Measurement of the Neutron Scattering Length of

We report a 0.08% measurement of the bound neutron scattering length of ^{4}He using neutron interferometry. The result is b=(3.0982±0.0021[stat]±0.0014[syst]) fm. The corresponding free atomic scattering length is a=(2.4746±0.0017[stat]±0.0011[syst]) fm. With this result the world average becomes b=(3.0993±0.0025) fm, a 2% downward shift and a reduction in uncertainty by more than a factor of six. Our result is in disagreement with a previous neutron interferometric measurement but is in good agreement with earlier measurements using neutron transmission.

Generation of a Lattice of Spin-Orbit Beams via Coherent Averaging.

We describe a highly robust method, applicable to both electromagnetic and matter-wave beams, that can produce a beam consisting of a lattice of orbital angular momentum (OAM) states coupled to a two-level system. We also define efficient protocols for controlling and manipulating the lattice characteristics. These protocols are applied in an experimental realization of a lattice of optical spin-orbit beams. The novel passive devices we demonstrate here are also a natural alternative to existing methods for producing single-axis OAM and spin-orbit beams. Our techniques provide new tools for investigations of chiral and topological materials with light and particle beams.

Three Phase-Grating Moiré Neutron Interferometer for Large Interferometer Area Applications.

We demonstrate a three phase-grating moiré neutron interferometer in a highly intense neutron beam as a robust candidate for large area interferometry applications and for the characterization of materials. This novel far-field moiré technique allows for broad wavelength acceptance and relaxed requirements related to fabrication and alignment, thus circumventing the main obstacles associated with perfect crystal neutron interferometry. We observed interference fringes with an interferometer length of 4 m and examined the effects of an aluminum 6061 alloy sample on the coherence of the system. Experiments to measure the autocorrelation length of samples and the universal gravitational constant are proposed and discussed.

Methods for preparation and detection of neutron spin-orbit states.

The generation and control of neutron orbital angular momentum (OAM) states and spin correlated OAM (spin-orbit) states provides a powerful probe of materials with unique penetrating abilities and magnetic sensitivity. We describe techniques to prepare and characterize neutron spin-orbit states, and provide a quantitative comparison to known procedures. The proposed detection method directly measures the correlations of spin state and transverse momentum, and overcomes the major challenges associated with neutrons, which are low flux and small spatial coherence length. Our preparation techniques, utilizing special geometries of magnetic fields, are based on coherent averaging and spatial control methods borrowed from nuclear magnetic resonance. The described procedures may be extended to other probes such as electrons and electromagnetic waves.

Experimental realization of decoherence-free subspace in neutron interferometry.

A decoherence-free subspace (DFS) is an important class of quantum-error-correcting (QEC) codes that have been proposed for fault-tolerant quantum computation. The applications of QEC techniques, however, are not limited to quantum-information processing (QIP). Here we demonstrate how QEC codes may be used to improve experimental designs of quantum devices to achieve noise suppression. In particular, neutron interferometry is used as a test bed to show the potential for adding quantum error correction to quantum measurements. We built a five-blade neutron interferometer that incorporates both a standard Mach-Zender configuration and a configuration based on a DFS. Experiments verify that the DFS interferometer is protected against low-frequency mechanical vibrations. We anticipate these improvements will increase the range of applications for matter-wave interferometry.

Release of arachidonic acid from human lymphocytes in response to mitogenic lectins.

After exposure to mitogenic lectins in vitro, human mononuclear cells (95% lymphocytes) that had been prelabeled with [14C]arachidonic acid rapidly released a portion of their radioactivity in the medium. Most of the released radioactivity was demonstrated to be free arachidonic acid. Although other sources are not excluded, the most important source of cell-bound radioactivity in the release reaction appeared to be phosphatidylinositol, suggesting that at least part of the response is occurring through an increase in phospholipase A2 activity. By gas liquid chromatography, other fatty acids were also shown to be released, but there was considerable selectivity in the response for arachidonic acid. The response was dependent on the availability of free Ca++ in the medium and was enhanced by serum proteins and unlabeled arachidonic acid. Most of the response appeared to be from the the lymphocytes themselves rather than from contaminating cells. The rapid generation of free arachidonic acid in response to mitogenic lectins suggests a possible role for arachidonic acid metabolites in the activation process.

Neutron sub-micrometre tomography from scattering data.

Neutrons are valuable probes for various material samples across many areas of research. Neutron imaging typically has a spatial resolution of larger than 20 µm, whereas neutron scattering is sensitive to smaller features but does not provide a real-space image of the sample. A computed-tomography technique is demonstrated that uses neutron-scattering data to generate an image of a periodic sample with a spatial resolution of ∼300 nm. The achieved resolution is over an order of magnitude smaller than the resolution of other forms of neutron tomography. This method consists of measuring neutron diffraction using a double-crystal diffractometer as a function of sample rotation and then using a phase-retrieval algorithm followed by tomographic reconstruction to generate a map of the sample's scattering-length density. Topological features found in the reconstructions are confirmed with scanning electron micrographs. This technique should be applicable to any sample that generates clear neutron-diffraction patterns, including nanofabricated samples, biological membranes and magnetic materials, such as skyrmion lattices.

Direct observation of spin rotation in Bragg scattering due to the spin-orbit interaction in silicon.

As a neutron scatters from a target nucleus, there is a small but measurable effect caused by the interaction of the neutron's magnetic dipole moment with that of the partially screened electric field of the nucleus. This spin-orbit interaction is typically referred to as Schwinger scattering and induces a small rotation of the neutron's spin on the order of 10-4 rad for Bragg diffraction from silicon. In our experiment, neutrons undergo greater than 100 successive Bragg reflections from the walls of a slotted, perfect-silicon crystal to amplify the total spin rotation. A magnetic field is employed to insure constructive addition as the neutron undergoes this series of reflections. The strength of the spin-orbit interaction, which is directly proportional to the electric field, was determined by measuring the rotation of the neutron's spin-polarization vector. Our measurements show good agreement with the expected variation of this rotation with the applied magnetic field, while the magnitude of the rotation is ≈40 % larger than expected.

Increased interference fringe visibility from the post-fabrication heat treatment of a perfect crystal silicon neutron interferometer.

We find that annealing a previously chemically etched interferometer at 800 °C dramatically increased the interference fringe visibility from 23% to 90%. The Bragg plane misalignments were also measured before and after annealing using neutron rocking curves, showing that Bragg plane alignment was improved across the interferometer after annealing. This suggests that current interferometers with low fringe visibility may be salvageable and that annealing may become an important step in the fabrication process of future neutron interferometers, leading to less need for chemical etching and larger more exotic neutron interferometers.

Alterations in cyclic AMP metabolism in human bronchial asthma. II. Leukocyte and lymphocyte responses to prostaglandins.

In an effort to clarify the basis for the reduced cyclic AMP response to catecholamines in leukocytes and lymphocytes from asthmatic donors the response of these cells to prostaglandins has been examined. Cells with an impaired beta adrenergic response had an essentially unaltered response to prostaglandin E(1) (PGE(1)) indicating the presence of selective beta adrenergic blockade. In contrast to what was observed with cells from asthmatic individuals, in normal control leukocytes with reduced catecholamine responsiveness PGE(1) responses were usually reduced as well, suggesting a different mechanism. The excellent cyclic AMP response to PGE(1) in cells from asthmatic donors would suggest that the defect in catecholamine responsiveness is at the level of the beta adrenergic receptor although a contributory role of altered substrate concentrations or increased phosphodiesterase activity is not formally excluded.

Alterations in cyclic AMP metabolism in human bronchial asthma. 3. Leukocyte and lymphocyte responses to steroids.

On the basis of serial studies the responsiveness of leukocytes and lymphocytes from asthmatic donors to catecholamines was increased during high dose corticosteroid therapy. Similar changes were observed in the cells of normal control subjects given 200 mg of hydrocortisone intravenously. The increase in responsiveness did not appear to be due to changes in lymphocyte subpopulations although this may be a contributing factor. In an effort to elucidate the basis for the improved response, in vitro effects of glucocorticoids on lymphocyte cyclic AMP concentrations were investigated. Glucocorticoids (prednisolone succinate, hydrocortisone, hydrocortisone phosphate, and hydrocortisone succinate) stimulated cyclic AMP accumulation in asthma and normal control lymphocytes, increases occurring within the first 2 min of incubation. In the absence of theophylline, responses were regularly obtained at 10 muM hydrocortisone and usually at 1 muM hydrocortisone but not at submicromolar steroid concentrations. Theophylline potentiated the cyclic AMP response to glucocorticoids and also increased the percentage of positive responses in the 0.01-1.0 muM corticosteroid range. Combinations of 1 muM hydrocortisone and 1 muM epinephrine were sometimes additive or synergistic but in many instances higher glucocorticoid concentrations were needed to obtain augmentation of the catecholamine response. The in vitro glucocorticoid effects may not fully explain their potentiating action in vivo.

Noise refocusing in a five-blade neutron interferometer.

We provide a quantum information description of a proposed five-blade neutron interferometer geometry and show that it is robust against low-frequency mechanical vibrations and dephasing due to the dynamical phase. The extent to which the dynamical phase affects the contrast in a neutron interferometer is experimentally shown. In our model, we consider the coherent evolution of a neutron wavepacket in an interferometer crystal blade and simulate the effect of mechanical vibrations and momentum spread of the neutron through the interferometer. The standard three-blade neutron interferometer is shown to be immune to dynamical phase noise but prone to noise from mechanical vibrations, and the decoherence free subspace four-blade neutron interferometer is shown to be immune to mechanical vibration noise but prone to noise from the dynamical phase. Here, we propose a five-blade neutron interferometer and show that it is immune to both low-frequency mechanical vibration noise and dynamical phase noise.

Neutron interferometer crystallographic imperfections and gravitationally induced quantum interference measurements.

Dynamical diffraction leads to an interesting, unavoidable set of interference effects for neutron interferometers. This experiment studies the interference signal from two and three successive Bragg diffractions in the Laue geometry. We find that intrinsic Bragg-plane misalignment in monolithic, "perfect" silicon neutron interferometers is relevant between successive diffracting crystals, as well as within the Borrmann fan for typical interferometer geometries. We show that the dynamical phase correction employed in the Colella, Overhauser, and Werner gravitationally induced quantum interference experiments is attenuated by slight, intrinsic misalignments between diffracting crystals, potentially explaining the long-standing 1% discrepancy between theory and experiment. This systematic may also impact precision measurements of the silicon structure factor, affecting previous and future measurements of the Debye-Waller factor and neutron-electron scattering length as well as potential fifth-force searches. For the interferometers used in this experiment, Bragg planes of different diffracting crystals were found to be misaligned by 10 to 40 nrad.

Neutron limit on the strongly-coupled chameleon field.

The physical origin of the dark energy that causes the accelerated expansion rate of the Universe is one of the major open questions of cosmology. One set of theories postulates the existence of a self-interacting scalar field for dark energy coupling to matter. In the chameleon dark energy theory, this coupling induces a screening mechanism such that the field amplitude is nonzero in empty space but is greatly suppressed in regions of terrestrial matter density. However measurements performed under appropriate vacuum conditions can enable the chameleon field to appear in the apparatus, where it can be subjected to laboratory experiments. Here we report the most stringent upper bound on the free neutron-chameleon coupling in the strongly coupled limit of the chameleon theory using neutron interferometric techniques. Our experiment sought the chameleon field through the relative phase shift it would induce along one of the neutron paths inside a perfect crystal neutron interferometer. The amplitude of the chameleon field was actively modulated by varying the millibar pressures inside a dual-chamber aluminum cell. We report a 95% confidence level upper bound on the neutron-chameleon coupling ß ranging from ß < 4.7 × 106 for a Ratra-Peebles index of n = 1 in the nonlinear scalar field potential to ß < 2.4 × 107 for n = 6, one order of magnitude more sensitive than the most recent free neutron limit for intermediate n. Similar experiments can explore the full parameter range for chameleon dark energy in the foreseeable future.

Decoupling of a neutron interferometer from temperature gradients.

Neutron interferometry enables precision measurements that are typically operated within elaborate, multi-layered facilities which provide substantial shielding from environmental noise. These facilities are necessary to maintain the coherence requirements in a perfect crystal neutron interferometer which is extremely sensitive to local environmental conditions such as temperature gradients across the interferometer, external vibrations, and acoustic waves. The ease of operation and breadth of applications of perfect crystal neutron interferometry would greatly benefit from a mode of operation which relaxes these stringent isolation requirements. Here, the INDEX Collaboration and National Institute of Standards and Technology demonstrates the functionality of a neutron interferometer in vacuum and characterize the use of a compact vacuum chamber enclosure as a means to isolate the interferometer from spatial temperature gradients and time-dependent temperature fluctuations. The vacuum chamber is found to have no depreciable effect on the performance of the interferometer (contrast) while improving system stability, thereby showing that it is feasible to replace large temperature isolation and control systems with a compact vacuum enclosure for perfect crystal neutron interferometry.

Adjunctive risperidone treatment in post-traumatic stress disorder: a preliminary controlled trial of effects on comorbid psychotic symptoms.

Positive and negative symptoms of psychosis may be common in patients with chronic post-traumatic stress disorder (PTSD), but few studies have investigated the use of antipsychotic agents in these patients. This preliminary study examined the potential efficacy of risperidone in treating psychotic symptoms associated with chronic PTSD. In a 5-week, prospective, randomized, double-blind, placebo-controlled trial, adjunctive risperidone treatment was assessed in 40 combat veterans with chronic PTSD and comorbid psychotic features. Most patients were receiving antidepressants and some other psychotics with doses of concurrent medications held constant for at least 1 month prior to and during the study. Thirty-seven patients completed at least 1 week of treatment with risperidone or placebo. The Positive and Negative Syndrome Scale (PANSS) and the Clinician Administered PTSD Scale (CAPS) were used to assess symptoms. The PANSS was the primary outcome measure. At treatment endpoint, risperidone-treated patients showed a significantly greater decrease from baseline, albeit modest, in psychotic symptoms (PANSS total scores) than placebo-treated patients (P < 0.05). CAPS ratings declined significantly in both groups but did not differ significantly between groups. However, CAPS re-experiencing subscale scores had greater improvement in the risperidone-treated patients at week 5 (P < 0.05, completer analysis) with a trend towards greater improvement versus placebo a endpoint (P < 0.1, LOCF). Risperidone was well tolerated with minimal extrapyramidal symptoms. These preliminary results support studying the potential efficacy of risperidone for treating global psychotic symptoms associated with chronic PTSD with a suggestion that core re-experiencing symptoms may also be responsive. Further research using randomized, controlled trial designs in larger patient groups are needed to define more adequately the role of risperidone and other atypical agents in PTSD.

A survey of police officers' experience with Tarasoff warnings in two states.

A desk sergeant at each of 48 Michigan police stations and 52 South Carolina police stations was surveyed about knowledge and experience of Tarasoff warnings. Respondents at 45 stations reported receiving warnings from mental health professionals, with a mean+/-SD of 3. 7+/-8.4 warnings a year. Only three respondents were familiar with the Tarasoff ruling. Twenty-four stations had a specific policy on such warnings. Twenty-seven stations would not warn a potential victim. Michigan stations were much more likely than South Carolina stations to have experience with or policies on Tarasoff warnings. Because police apparently have limited experience with Tarasoff warnings, calling them may not be the best way to protect potential victims from patients making threats.

Precision measurement of the n-3He incoherent scattering length using neutron interferometry.

We report the first measurement of the low-energy neutron-(3)He incoherent scattering length using neutron interferometry: b_{i};{'} = (-2.512 +/- 0.012 stat +/- 0.014 syst) fm. This is in good agreement with a recent calculation using the AV18 + 3N potential. The neutron-(3)He scattering lengths are important for testing and developing nuclear potential models that include three-nucleon forces, effective field theories for few-body nuclear systems, and neutron scattering measurements of quantum excitations in liquid helium. This work demonstrates the first use of a polarized nuclear target in a neutron interferometer.

Measurements of the vertical coherence length in neutron interferometry.

The study and use of macroscopic quantum coherence requires long coherence lengths. Here we describe an approach to measuring the vertical coherence length in neutron interferometry, along with improvements to the NIST interferometer that led to a measured coherence length of 790 A. The measurement is based on introducing a path separation and measuring the loss in contrast as this separation is increased. The measured coherence length is consistent with the momentum distribution of the neutron beam. Finally, we demonstrate that the loss in contrast with beam displacement in one leg of the interferometer can be recovered by introducing a corresponding displacement in the second leg.

Modulation of IL-4 production in murine spleen cells by prostaglandins.

Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable suppression by PGE2 was seen after priming by anti-CD3 epsilon antibody instead of Con A or with other changes in the culture conditions. PGE2 was an effective inhibitor after elimination of Ly2.2+ T cells, consistent with a direct effect on Th2 cells. In the absence of added prostaglandins, IL-4 production was enhanced 1.5- to 7.0-fold by 0.2-2.0 microM indomethacin, indicating that endogenous arachidonate metabolites such as PGE2 and PGI2 regulate IL-4 production in our usual culture system. The inhibition of Th2 cell secretion by PGE2 in vitro may have physiologic and pharmacologic implications for the regulation of Th2 cell function and IgE production in vivo.