Detalhe da pesquisa
1.
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Bioorg Med Chem Lett
; 28(21): 3446-3453, 2018 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30268701
2.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 22(16): 5303-7, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22795627
3.
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Bioorg Med Chem Lett
; 18(9): 2865-70, 2008 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18420408
4.
FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques.
Pharmacol Res Perspect
; 4(3): e00218, 2016 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27433338
5.
Using in vitro human tissues to predict pharmacokinetic properties.
Curr Opin Drug Discov Devel
; 7(1): 69-74, 2004 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-14982150
6.
Improved pharmacokinetic and bioavailability support of drug discovery using serial blood sampling in mice.
J Pharm Sci
; 98(5): 1877-84, 2009 May.
Artigo
Inglês
| MEDLINE | ID: mdl-18803263
7.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(1): 123-8, 2006 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16236500
8.
Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists.
Bioorg Med Chem Lett
; 15(7): 1857-61, 2005 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15780621