Pesquisa | Secretaria de Estado da Saúde

1.

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.

Corkill, Dominic J; Hunt, Alan N; Hinrichs, Mary Jane; White, Nicholas; Rebelatto, Marlon; Roskos, Lorin; Nys, Josquin; Scott, Alison; Robinson, Matthew J; Ryan, Patricia; Postle, Anthony D; Sleeman, Matthew A.

Clin Sci (Lond) ; 135(22): 2559-2573, 2021 11 26.

Artigo Inglês | MEDLINE | ID: mdl-34778899

2.

Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis.

Hunt, Alan N; Malur, Anagha; Monfort, Tual; Lagoudakis, Pavlos; Mahajan, Sumeet; Postle, Anthony D; Thomassen, Mary Jane.

Am J Respir Cell Mol Biol ; 57(4): 448-458, 2017 10.

Artigo Inglês | MEDLINE | ID: mdl-28489415

3.

Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells.

Smith, Wendy S; Baker, Ella J; Holmes, Suzanne E; Koster, Grielof; Hunt, Alan N; Johnston, David A; Flavell, Sopsamorn U; Flavell, David J.

Biochim Biophys Acta Biomembr ; 1859(5): 993-1007, 2017 May.

Artigo Inglês | MEDLINE | ID: mdl-28235471

4.

Regulation of lung surfactant phospholipid synthesis and metabolism.

Goss, Victoria; Hunt, Alan N; Postle, Anthony D.

Biochim Biophys Acta ; 1831(2): 448-58, 2013 Feb.

Artigo Inglês | MEDLINE | ID: mdl-23200861

5.

Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.

Plantier, Laurent; Besnard, Valérie; Xu, Yan; Ikegami, Machiko; Wert, Susan E; Hunt, Alan N; Postle, Anthony D; Whitsett, Jeffrey A.

J Biol Chem ; 287(13): 10099-10114, 2012 Mar 23.

Artigo Inglês | MEDLINE | ID: mdl-22267724

6.

Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid.

Garner, Kathryn; Hunt, Alan N; Koster, Grielof; Somerharju, Pentti; Groves, Emily; Li, Michelle; Raghu, Padinjat; Holic, Roman; Cockcroft, Shamshad.

J Biol Chem ; 287(38): 32263-76, 2012 Sep 14.

Artigo Inglês | MEDLINE | ID: mdl-22822086

7.

Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice.

Besnard, Valérie; Matsuzaki, Yohei; Clark, Jean; Xu, Yan; Wert, Susan E; Ikegami, Machiko; Stahlman, Mildred T; Weaver, Timothy E; Hunt, Alan N; Postle, Anthony D; Whitsett, Jeffrey A.

Am J Physiol Lung Cell Mol Physiol ; 298(5): L646-59, 2010 May.

Artigo Inglês | MEDLINE | ID: mdl-20190032

8.

Probing phospholipid dynamics by electrospray ionisation mass spectrometry.

Postle, Anthony D; Wilton, David C; Hunt, Alan N; Attard, George S.

Prog Lipid Res ; 46(3-4): 200-24, 2007.

Artigo Inglês | MEDLINE | ID: mdl-17540449

9.

Completing the cycles; the dynamics of endonuclear lipidomics.

Hunt, Alan N.

Biochim Biophys Acta ; 1761(5-6): 577-87, 2006.

Artigo Inglês | MEDLINE | ID: mdl-16581290

10.

Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha.

Hunt, Alan N; Skippen, Alison J; Koster, Grielof; Postle, Anthony D; Cockcroft, Shamshad.

Biochim Biophys Acta ; 1686(1-2): 50-60, 2004 Nov 08.

Artigo Inglês | MEDLINE | ID: mdl-15522822

11.

Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells.

Rodway, Helen A; Hunt, Alan N; Kohler, Janice A; Postle, Anthony D; Lillycrop, Karen A.

Biochem J ; 382(Pt 1): 83-91, 2004 Aug 15.

Artigo Inglês | MEDLINE | ID: mdl-15171682

12.

A comparison of the molecular specificities of whole cell and endonuclear phosphatidylcholine synthesis.

Hunt, Alan N; Clark, Graeme T; Neale, James R; Postle, Anthony D.

FEBS Lett ; 530(1-3): 89-93, 2002 Oct 23.

Artigo Inglês | MEDLINE | ID: mdl-12387872

13.

Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes.

Postle, Anthony D; Henderson, Neil G; Koster, Grielof; Clark, Howard W; Hunt, Alan N.

Chem Phys Lipids ; 164(6): 549-55, 2011 Sep.

Artigo Inglês | MEDLINE | ID: mdl-21515243

14.

Phosphatidylcholine biosynthesis inside the nucleus: is it involved in regulating cell proliferation?

Hunt, Alan N; Postle, Anthony D.

Adv Enzyme Regul ; 44: 173-86, 2004.

Artigo Inglês | MEDLINE | ID: mdl-15581489

15.

Dynamic lipidomics with stable isotope labelling.

Postle, Anthony D; Hunt, Alan N.

J Chromatogr B Analyt Technol Biomed Life Sci ; 877(26): 2716-21, 2009 Sep 15.

Artigo Inglês | MEDLINE | ID: mdl-19395321

16.

Dynamic lipidomics of the nucleus.

Hunt, Alan N.

J Cell Biochem ; 97(2): 244-51, 2006 Feb 01.

Artigo Inglês | MEDLINE | ID: mdl-16240373

17.

Mass spectrometry determination of endonuclear phospholipid composition and dynamics.

Hunt, Alan N; Postle, Anthony D.

Methods ; 39(2): 104-11, 2006 Jun.

Artigo Inglês | MEDLINE | ID: mdl-16831558

18.

Diclofenac mediated derangement of neuroblastoma cell lipidomic profiles is accompanied by increased phosphatidylcholine biosynthesis.

Hunt, Alan N; Macken, Marita; Koster, Grielof; Kohler, Janice A; Postle, Anthony D.

Adv Enzyme Regul ; 48: 74-87, 2008.

Artigo Inglês | MEDLINE | ID: mdl-18157948

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