Detalhe da pesquisa
1.
Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Lancet Oncol
; 22(12): 1764-1776, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34780709
2.
Development and validation of an LC-MS/MS method for the quantitative analysis of the adenosine A2a receptor antagonist NIR178 and its monohydroxy metabolite in human plasma: Application to clinical pharmacokinetics.
Biomed Chromatogr
; 34(10): e4909, 2020 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-32485782
3.
Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.
Antimicrob Agents Chemother
; 58(2): 678-86, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24217697
4.
Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer.
Clin Cancer Res
; 28(11): 2313-2320, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35254415
5.
ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients with ALK-Positive Non-Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges.
Clin Cancer Res
; 28(12): 2506-2516, 2022 06 13.
Artigo
Inglês
| MEDLINE | ID: mdl-35091443
6.
Effect of ceritinib on the pharmacokinetics of coadministered CYP3A and 2C9 substrates: a phase I, multicenter, drug-drug interaction study in patients with ALK + advanced tumors.
Cancer Chemother Pharmacol
; 87(4): 475-486, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33394101
7.
Validated stability-indicating RP-HPLC method for the determination of rimonabant in a pharmaceutical dosage form.
J AOAC Int
; 93(3): 869-75, 2010.
Artigo
Inglês
| MEDLINE | ID: mdl-20629389
8.
Development and Qualification of a Drug-Disease Modeling Platform to Characterize Clinically Relevant Endpoints in Type 2 Diabetes Trials.
Clin Pharmacol Ther
; 104(4): 699-708, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29271001