Detalhe da pesquisa
1.
Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights.
Bioorg Chem
; 149: 107471, 2024 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-38823311
2.
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers.
Bioorg Chem
; 144: 107105, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38219482
3.
Exploring the cytotoxic effect and CDK-9 inhibition potential of novel sulfaguanidine-based azopyrazolidine-3,5-diones and 3,5-diaminoazopyrazoles.
Bioorg Chem
; 133: 106397, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36753965
4.
Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations.
Bioorg Chem
; 140: 106789, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37611530
5.
The effect of novel synthetic semicarbazone- and thiosemicarbazone-linked 1,2,3-triazoles on the apoptotic markers, VEGFR-2, and cell cycle of myeloid leukemia.
Bioorg Chem
; 127: 105968, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35728289
6.
Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1,2,3-triazole-chalcone conjugates.
Bioorg Chem
; 123: 105762, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35358822
7.
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.
Bioorg Med Chem
; 42: 116266, 2021 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34126285
8.
Synthesis, cytotoxicity of some pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action.
Bioorg Chem
; 102: 104053, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32673889
9.
Novel benzochromenes: design, synthesis, cytotoxicity, molecular docking and mechanistic investigations.
Future Med Chem
; 16(2): 105-123, 2024 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38226455
10.
Aminopyridone-linked benzimidazoles: a fragment-based drug design for the development of CDK9 inhibitors.
Future Med Chem
; 15(14): 1213-1232, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37584185