Mental state decoders: game-changers or wishful thinking?

Decoding mental and perceptual states using fMRI has become increasingly popular over the past two decades, with numerous highly-cited studies published in high-profile journals. Nevertheless, what have we learned from these decoders? In this opinion, we argue that fMRI-based decoders are not neurophysiologically informative and are not, and likely cannot be, applicable to real-world decision-making. The former point stems from the fact that decoding models cannot disentangle neural mechanisms from their epiphenomena. The latter point stems from both logical and ethical constraints. Constructing decoders requires precious time and resources that should instead be directed toward scientific endeavors more likely to yield meaningful scientific progress.

The blink reflex and its modulation - Part 1: Physiological mechanisms.

The blink reflex (BR) is a protective eye-closure reflex mediated by brainstem circuits. The BR is usually evoked by electrical supraorbital nerve stimulation but can be elicited by a variety of sensory modalities. It has a long history in clinical neurophysiology practice. Less is known, however, about the many ways to modulate the BR. Various neurophysiological techniques can be applied to examine different aspects of afferent and efferent BR modulation. In this line, classical conditioning, prepulse and paired-pulse stimulation, and BR elicitation by self-stimulation may serve to investigate various aspects of brainstem connectivity. The BR may be used as a tool to quantify top-down modulation based on implicit assessment of the value of blinking in a given situation, e.g., depending on changes in stimulus location and probability of occurrence. Understanding the role of non-nociceptive and nociceptive fibers in eliciting a BR is important to get insight into the underlying neural circuitry. Finally, the use of BRs and other brainstem reflexes under general anesthesia may help to advance our knowledge of the brainstem in areas not amenable in awake intact humans. This review summarizes talks held by the Brainstem Special Interest Group of the International Federation of Clinical Neurophysiology at the International Congress of Clinical Neurophysiology 2022 in Geneva, Switzerland, and provides a state-of-the-art overview of the physiology of BR modulation. Understanding the principles of BR modulation is fundamental for a valid and thoughtful clinical application (reviewed in part 2) (Gunduz et al., submitted).