Detalhe da pesquisa
1.
Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.
Arch Pharm (Weinheim)
; 357(2): e2300536, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37932028
2.
Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors.
Drug Dev Res
; 85(3): e22193, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38685605
3.
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors.
Bioorg Chem
; 135: 106492, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37001471
4.
Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity.
J Enzyme Inhib Med Chem
; 38(1): 2201403, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37078174
5.
Histone Acetyltransferase and Deacetylase Inhibitors-New Aspects and Developments.
Int J Mol Sci
; 24(23)2023 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38069308
6.
Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity.
Bioorg Chem
; 126: 105888, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35661530
7.
Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.
Molecules
; 27(8)2022 Apr 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35458724
8.
Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity.
Bioorg Chem
; 116: 105318, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34488123
9.
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
Int J Mol Sci
; 23(1)2021 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35008795
10.
Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation.
J Enzyme Inhib Med Chem
; 35(1): 298-305, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31809607
11.
Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase.
Bioorg Chem
; 85: 337-348, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30658233
12.
Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies.
Bioorg Chem
; 87: 794-802, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30978604
13.
One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells.
J Enzyme Inhib Med Chem
; 33(1): 309-318, 2018 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-29281924
14.
Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation.
J Enzyme Inhib Med Chem
; 33(1): 686-700, 2018 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-29560733
15.
Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation.
Molecules
; 23(6)2018 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29914120
16.
Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties.
Molecules
; 21(6)2016 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27294903
17.
Synthesis and biological evaluation of some N-arylpyrazoles and pyrazolo[3,4-d]pyridazines as anti-inflammatory agents.
Arch Pharm (Weinheim)
; 346(9): 688-98, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-24006310
18.
Development of Pyrazine-Anilinobenzamides as Histone Deacetylase HDAC1-3 Selective Inhibitors and Biological Testing Against Pancreas Cancer Cell Lines.
Methods Mol Biol
; 2589: 145-155, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36255623
19.
Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3ß inhibitors.
BMC Chem
; 17(1): 127, 2023 Sep 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37759329
20.
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells.
J Adv Res
; 2023 Jul 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37467961