Detalhe da pesquisa
1.
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Genes Dev
; 32(3-4): 309-320, 2018 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29491137
2.
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Biochemistry
; 62(14): 2147-2160, 2023 07 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37403936
3.
Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists.
J Biol Chem
; 298(11): 102539, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36179791
4.
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer.
Mol Cancer Ther
; 21(6): 890-902, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35642432
5.
Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.
ACS Med Chem Lett
; 12(1): 93-98, 2021 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33488969
6.
Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 10(1): 2527, 2019 Jun 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31164653
7.
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
Cancer Discov
; 8(9): 1176-1193, 2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29991605
8.
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 8(1): 103, 2017 07 24.
Artigo
Inglês
| MEDLINE | ID: mdl-28740126