Detalhe da pesquisa
1.
Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators.
Proc Natl Acad Sci U S A
; 117(40): 24920-24928, 2020 10 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32958636
2.
Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.
J Biol Chem
; 295(15): 5067-5080, 2020 04 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32139508
3.
NaV 1.6 regulates excitability of mechanosensitive sensory neurons.
J Physiol
; 597(14): 3751-3768, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31087362
4.
δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails.
Proc Biol Sci
; 282(1811)2015 Jul 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26156767
5.
Topical Oxaliplatin Produces Gain- and Loss-of-Function in Multiple Classes of Sensory Afferents.
J Pain
; 25(1): 88-100, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37524219
6.
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.
Nat Commun
; 14(1): 2442, 2023 04 28.
Artigo
Inglês
| MEDLINE | ID: mdl-37117223
7.
Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation.
Eur J Pharmacol
; 925: 175013, 2022 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35537491
8.
Passive transfer of fibromyalgia symptoms from patients to mice.
J Clin Invest
; 131(13)2021 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34196305
9.
Animal toxins - Nature's evolutionary-refined toolkit for basic research and drug discovery.
Biochem Pharmacol
; 181: 114096, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32535105
10.
Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe.
Biomedicines
; 8(6)2020 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32545167
11.
Neurotoxic peptides from the venom of the giant Australian stinging tree.
Sci Adv
; 6(38)2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32938666
12.
Toxins as tools: Fingerprinting neuronal pharmacology.
Neurosci Lett
; 679: 4-14, 2018 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-29425731
13.
The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.
J Med Chem
; 61(4): 1730-1736, 2018 02 22.
Artigo
Inglês
| MEDLINE | ID: mdl-29378414
14.
Sodium Channels and Venom Peptide Pharmacology.
Adv Pharmacol
; 79: 67-116, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28528674
15.
The pharmacology of voltage-gated sodium channel activators.
Neuropharmacology
; 127: 87-108, 2017 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-28416444
16.
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.
Sci Rep
; 7: 42810, 2017 02 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28225079
17.
NaV1.7 as a pain target - From gene to pharmacology.
Pharmacol Ther
; 172: 73-100, 2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-27916648