Detalhe da pesquisa
1.
Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.
Bioorg Chem
; 115: 105244, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34452759
2.
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Eur J Med Chem
; 270: 116354, 2024 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38554474
3.
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.
Bioorg Med Chem Lett
; 23(9): 2688-91, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23522563
4.
7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex.
ACS Infect Dis
; 9(3): 668-691, 2023 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36853190
5.
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
J Med Chem
; 66(5): 3540-3565, 2023 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36812492
6.
Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
Chem Res Toxicol
; 24(7): 1012-30, 2011 Jul 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21667953
7.
Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
Bioorg Med Chem Lett
; 20(9): 2864-7, 2010 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20347304
8.
Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
Bioorg Med Chem Lett
; 20(9): 2868-71, 2010 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20338760
9.
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs).
Bioorg Med Chem Lett
; 18(1): 405-8, 2008 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17980583
10.
1-Hydroxy-2-pyridinone-based MMP inhibitors: synthesis and biological evaluation for the treatment of ischemic stroke.
Bioorg Med Chem Lett
; 18(1): 409-13, 2008 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17981034
11.
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
J Med Chem
; 60(8): 3511-3517, 2017 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28300404
12.
Pyridinylimidazole based p38 MAP kinase inhibitors.
Curr Top Med Chem
; 2(9): 1011-20, 2002 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-12171568
13.
Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
J Med Chem
; 46(10): 1989-96, 2003 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-12723961
14.
JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.
ACS Chem Neurosci
; 5(10): 1005-19, 2014 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25203719
15.
Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease.
J Med Chem
; 55(3): 1402-17, 2012 Feb 09.
Artigo
Inglês
| MEDLINE | ID: mdl-22239465
16.
Adenosine A(2A) Receptor Antagonists and Parkinson's Disease.
ACS Chem Neurosci
; 2(10): 555-67, 2011 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-22860156
17.
In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.
J Med Chem
; 53(22): 8104-15, 2010 Nov 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20973483
18.
Regioselective preparation of 2-substituted 3,4-diaryl pyrroles: a concise total synthesis of ningalin B.
J Org Chem
; 67(26): 9439-42, 2002 Dec 27.
Artigo
Inglês
| MEDLINE | ID: mdl-12492350