Detalhe da pesquisa
1.
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia.
J Pharmacokinet Pharmacodyn
; 50(5): 351-364, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37243877
2.
Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.
Bioorg Med Chem Lett
; 28(7): 1211-1218, 2018 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29519738
3.
Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.
Bioorg Med Chem Lett
; 28(23-24): 3766-3773, 2018 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30340896
4.
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
Bioorg Med Chem Lett
; 27(23): 5131-5138, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29100801
5.
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.
Bioorg Med Chem Lett
; 27(11): 2594-2601, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28400234
6.
Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.
Bioorg Med Chem Lett
; 26(24): 5977-5984, 2016 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27865703
7.
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.
Bioorg Med Chem Lett
; 24(9): 2073-8, 2014 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24725435
8.
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II.
Bioorg Med Chem Lett
; 24(15): 3238-42, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24980052
9.
Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
Eur Heart J Cardiovasc Pharmacother
; 8(6): 578-586, 2022 Sep 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34448822
10.
Pharmacokinetics and Determination of Tumor Interstitial Distribution of a Therapeutic Monoclonal Antibody Using Large-Pore Microdialysis.
J Pharm Sci
; 110(8): 3061-3068, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33819461
11.
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
J Neurosci
; 29(45): 14271-86, 2009 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-19906975
12.
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.
J Pharmacol Exp Ther
; 327(3): 941-53, 2008 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-18772318
13.
Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.
J Pharm Sci
; 106(9): 2853-2859, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28414146
14.
Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.
AAPS J
; 19(2): 334-342, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27943149
15.
Statins and osteoporosis: new role for old drugs.
J Pharm Pharmacol
; 58(1): 3-18, 2006 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-16393459
16.
Distribution of lovastatin to bone and its effect on bone turnover in rats.
J Pharm Pharmacol
; 58(11): 1451-8, 2006 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17132207
17.
Microdialysis of Large Molecules.
J Pharm Sci
; 105(11): 3233-3242, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27671236
18.
Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.
J Med Chem
; 58(20): 8292-308, 2015 Oct 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26421921
19.
(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.
ACS Chem Neurosci
; 2(8): 471-482, 2011 Aug 17.
Artigo
Inglês
| MEDLINE | ID: mdl-21927650
20.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.
ACS Chem Neurosci
; 1(2): 104-121, 2010.
Artigo
Inglês
| MEDLINE | ID: mdl-21961051