Detalhe da pesquisa
1.
Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.
Cell
; 160(6): 1087-98, 2015 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25768905
2.
Carbogen-Induced Respiratory Acidosis Blocks Experimental Seizures by a Direct and Specific Inhibition of NaV1.2 Channels in the Axon Initial Segment of Pyramidal Neurons.
J Neurosci
; 43(10): 1658-1667, 2023 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36732074
3.
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
J Biol Chem
; 299(12): 105475, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37981208
4.
ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome.
Hepatology
; 78(5): 1337-1351, 2023 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37021797
5.
Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.
Mol Psychiatry
; 28(6): 2445-2461, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37012334
6.
Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice.
Proc Natl Acad Sci U S A
; 118(27)2021 07 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34187891
7.
PFTK1 kinase regulates axogenesis during development via RhoA activation.
BMC Biol
; 21(1): 240, 2023 10 31.
Artigo
Inglês
| MEDLINE | ID: mdl-37907898
8.
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.
Acta Neuropathol
; 147(1): 1, 2023 11 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38019311
9.
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.
Nature
; 544(7650): 367-371, 2017 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28405022
10.
The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration.
Nucleic Acids Res
; 49(2): 657-673, 2021 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33367834
11.
Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
Epilepsia
; 63(10): e125-e131, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35892317
12.
Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.
Ann Neurol
; 87(3): 339-346, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31943325
13.
Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice.
Neurobiol Dis
; 124: 133-140, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30458231
14.
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.
Brain
; 141(12): 3428-3442, 2018 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30496365
15.
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Nature
; 498(7454): 325-331, 2013 Jun 20.
Artigo
Inglês
| MEDLINE | ID: mdl-23719381
16.
Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
Nat Genet
; 39(3): 373-9, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17322884
17.
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Nature
; 452(7188): 713-8, 2008 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-18337722
18.
Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
Proc Natl Acad Sci U S A
; 108(5): 2142-7, 2011 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21245341
19.
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.
Mol Neurodegener
; 19(1): 13, 2024 Jan 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38282024
20.
Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease.
bioRxiv
; 2024 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38464319