High-Intensity Functional Training Induces Superior Training Adaptations Compared With Traditional Military Physical Training.

ABSTRACT: Helén, J, Kyröläinen, H, Ojanen, T, Pihlainen, K, Santtila, M, Heikkinen, R, and Vaara, JP. High-intensity functional training induces superior training adaptations compared with traditional military physical training. J Strength Cond Res 37(12): 2477-2483, 2023-This study examined the effectiveness of concurrent strength and endurance training with an emphasis on high-intensity functional training (HIFT) during military service. Voluntary male conscripts (aged 18-28 years) were placed in either an experimental (EXP: n = 50-66) or a control (CON: n = 50-67) group. The training for the EXP group included HIFT using body mass, sandbags, and kettlebells. The CON group trained according to the current practice. Physical performance and body composition were assessed at baseline (PRE), at week 10 (MID), and after (POST) the 19-week training period. Significance was set at p < 0.05. The total distance covered in a 12-minute running test increased in both groups, but the change in EXP was superior to the change in CON (11.6%, ES: 0.79 vs. 5.7%, ES: 0.33; p = 0.027). Maximal strength and power characteristics increased in EXP (3.1-5.0%), whereas no improvements were observed in CON. Conscripts with the highest initial fitness showed no improvements in physical performance in either group. Body mass and waist circumference decreased in EXP, whereas CON showed an increase in muscle mass. These findings suggest that HIFT is an effective and time-efficient approach to improve soldiers' aerobic fitness during military service. For the optimal development of strength, the training equipment used may not have provided sufficient and progressive loading to yield considerable strength adaptations. More focus should be placed on sufficient intensity and volume in both strength and endurance training, especially for the most fit soldiers.

Performance changes during repeated military occupational test and its associations to physical performance.

The present study investigated performance changes during three runs (1 min recovery) of repeated military simulation task test (RMST) and its associations with physical performance. Voluntary male soldiers (N = 114) participated in a series of measurements of physical performance. Lower body explosive force production, anaerobic endurance and upper body strength endurance together explained 58% of the variance in the first RSMT (p < 0.001). The same variables explained the variance in the second and third runs of RSMT by 60% and 51%, but explosive force production was replaced with aerobic endurance, assessed by the 3.2 km loaded run (p < 0.001). This study demonstrated that the role of explosive power of the lower body decreased and military specific aerobic endurance increased when occupational performance was assessed under acute fatigue even during a short high-intensity test. These results may benefit tactical strength and conditioning coaches in training optimisation for improved occupational performance in military.Practioners summary: Soldiers are required to perform occupational tasks in a repeated manner with short recovery time. In the present study, the role of explosive power of the lower body decreased and military specific aerobic endurance increased when occupational performance was assessed with a repeated high-intensity task specific performance test.

Effects of 6-Month Military Deployment on Physical Fitness, Body Composition, and Selected Health-Related Biomarkers.

ABSTRACT: Sedliak, M, Sedliak, P, and Vaara, JP. Effects of 6-month military deployment on physical fitness, body composition, and selected health-related biomarkers. J Strength Cond Res 35(4): 1074-1081, 2021-The purpose was to study the effects of 6-month deployment to Afghanistan on physical performance, anthropometrical, and health-related biochemical parameters in soldiers with sedentary to light physical workload shifts. Twenty-five male soldiers (30 ± 4 years) volunteered and were measured before and after the 6-month deployment. Another 25 home-land-based male soldiers (30 ± 6 years) served as controls. Total body fat percentage decreased in deployed soldiers (Pre: 23.2 ± 5.3 vs. Post: 20.8 ± 5.5%, p < 0.05), whereas no change was observed in control (20.2 ± 6.9 vs. 20.5 ± 7.0%). Physical performance improved in deployed soldiers in 4 × 10-m shuttle run (10.86 ± 0.90 vs. 10.49 ± 0.63 seconds) and pull-up test to failure (4.7 ± 3.7 vs. 7.5 ± 6.7 rep.) (p < 0.05) but not in the controls for the respective tests (10.28 ± 0.74 vs. 10.40 ± 0.76 seconds and 10.2 ± 7.8 vs. 10.2 ± 7.5 rep.). Deployed soldiers also improved 5-km run with a simulated combat gear time (29.2 ± 3.1 vs. 27.4 ± 3.0 minutes), whereas in control the time increased (26.4 ± 2.9 vs. 27.8 ± 2.6 minutes, p < 0.05). Load at maximum power output in bench press was improved in deployed soldiers (51.6 ± 11.3 vs. 56.2 ± 12.6 kg, p < 0.05). Serum glucose and creatinine decreased (5.46 ± 0.53 vs. 4.87 ± 0.74 mmol·L-1 and 87.4 ± 10.7 vs. 80.9 ± 10.2 µmmol·L-1, respectively), and hemoglobin and hematocrite increased (15.13 ± 0.82 vs. 16.75 ± 0.85 g·dl-1 and 45.3 ± 1.5 vs. 48.1 ± 2.4%, respectively, p < 0.05) in the deployment group. In conclusion, after 6-month deployment consisting of sedentary and low physical occupational load, soldiers were able to increase their physical fitness and decrease their body fat content and improve selected health-related biochemical parameters. Therefore, the adoption and promotion of leisure-time physical activity in soldiers during deployments is essential to maintain combat readiness.

Cardiorespiratory and muscular fitness in young adult Finnish men between 2003 and 2015.

INTRODUCTION: Physical fitness is strongly related to health and may offer valuable information about public health. We investigated trends in physical fitness, leisure-time physical activity (LTPA), and anthropometry of young healthy adult Finnish men in representative population-based samples between 2003 and 2015. METHODS: Three independent cross-sectional samples of 18- to 35-year-old Finnish men were assessed in 2003 (n = 889), 2008 (n = 803), and 2015 (n = 690). Cardiorespiratory (VO2 max) and muscular fitness (1-minute sit-ups and push-ups), body mass, and height were measured. Self-reported LTPA was assessed. RESULTS: After adjusting for age, education, and smoking, cardiorespiratory fitness was higher in 2003 (mean: 43.5, 95%CI: 42.9-44.1 mL/kg/min) compared to 2008 (41.3, 95%CI: 40.7-41.9 mL/kg/min) and 2015 (40.6, 95%CI: 40.0-41.2 mL/kg/min) (P < .001), whereas no difference was observed between 2008 and 2015. The lowest values in muscular fitness were observed in 2003, while no clear trends were further noticed. The adjusted BMI was higher in 2008 (25.1, 95%CI: 24.9-25.4) and 2015 (25.3, 95%CI: 25.3, 95%CI: 25.0-25.6) compared to 2003 (24.5, 95%CI: 24.3-24.8) (P < .005). In 2015, a higher proportion of individuals exercised at least four times per week compared to 2003 and 2008 (P < .05). CONCLUSION: The decrease in cardiorespiratory fitness that took place between 2003 and 2008 plateaued after 2008. The plateau is in accordance with the previously observed trend of 5-10 years younger Finnish men. Moreover, muscular fitness was for the most part higher in 2008 and 2015 compared to 2003. Efforts directed to promote regular physical activity and improve physical fitness are needed.

Relationship between different domains of physical activity and positive mental health among young adult men.

BACKGROUND: There is growing evidence on positive effects of physical activity (PA) on mental health. However, the focus of previous research on this relationship has typically been on mental health from the perspective of mental health problems rather than from the perspective of mental wellbeing. Further, previous research has commonly focused rather on leisure time PA without evidence on the role of other domains of PA. The aim of the present cross-sectional study was to investigate the relationship between positive mental health (PMH) and different domains of PA in young Finnish men. The secondary aim was to examine the reasons for physical inactivity among individuals with a low level of PMH. METHODS: Positive mental health (measured with Short Warwick-Edinburgh Mental Wellbeing Scale, SWEMWBS), self-reported leisure time, occupational and commuting PA as well as reasons for physical inactivity were measured using questionnaires (n = 456, mean age 29 years) among young Finnish males. Logistic regression modelling was used to generate odds for low and high levels of positive mental health for different levels of PA and sociodemographic variables. RESULTS: A weak positive association between leisure time PA and PMH was found in men with a low level of PMH (OR = 0.33, 95% CI 0.13-0.86). No association was found in the domains of commuting and occupational PA. Multivariate logistic regression analysis showed lower level of leisure time PA, unemployment and being single independently predicting low level of PMH. No associations were found between any domains of PA and high level of PMH. The most common reasons for physical inactivity among men with a low level of PMH were lack of interest (28%) and unwillingness to practise sports alone (27%). CONCLUSIONS: The relationship between physical activity and positive mental health seems to vary between different domains of physical activity. The findings highlight the important role of leisure time physical activity, particularly in men with a low level of positive mental health. Strategies aimed at increasing physical activity for mental health benefits should focus particularly on providing opportunities for leisure time physical activity involving social interactions for men with lower mental wellbeing.

Muscular and cardiorespiratory fitness are associated with health-related quality of life among young adult men.

BACKGROUND: Despite numerous studies providing evidence for positive effects of physical activity and physical fitness, evidence for association between physical fitness and health-related quality of life (HRQoL) in young adults is limited. The aim of the present cross-sectional study was to investigate the association of cardiorespiratory and muscular fitness with HRQoL from the perspective of its physical and mental components among young adult Finnish males. METHODS: The sample consisted of 754 men, with the mean age of 26 years (SD 6.7 years), who participated in the military refresher training. HRQoL was measured using the Finnish RAND 36-item health survey. Cardiorespiratory fitness was determined by a bicycle ergometer test, and muscular fitness by various tests measuring maximal strength and muscular endurance. Logistic regression modelling was used to compare low, moderate and high physical and mental component of HRQoL scores to the respective levels of muscular and cardiorespiratory fitness. RESULTS: The findings of the adjusted (age, educational level, marital status, employment status, smoking, use of alcohol and BMI) analysis showed that cardiorespiratory and muscular fitness are positively associated with both physical and mental components of HRQoL. In terms of the physical component of HRQoL, even a moderate fitness level was positively associated with better HRQoL. In terms of the mental component of HRQoL, the impact was seen only in the group with the highest fitness level. CONCLUSIONS: The findings suggest a positive contribution of physical fitness to mental health and highlight the importance of both muscular and cardiorespiratory fitness in the promotion of HRQoL. Even lighter forms of physical activity that result in moderate physical fitness could contribute to the physical component of HRQoL. In terms of the mental component of HRQoL, higher levels of physical fitness may be needed to gain higher levels of HRQoL among young males.

Pressure Stabilization of Criegee Intermediates Formed from Symmetric trans-Alkene Ozonolysis.

We explore the pressure dependence of a stabilized Criegee Intermediate (sCI) formation from a sequence of trans-alkene ozonolysis reactions. To study the effect of carbon chain length on the stabilization, we select five symmetric trans-alkenes ranging from trans-2-butene (C4) through trans-7-tetradecene (C14). We measure the pressure falloff curves for each alkene from 50 to 900 Torr in a flow reactor using conversion of SO2 to H2SO4 with and without an OH scavenger, and subsequent detection of H2SO4 with a nitrate chemical ionization mass spectrometer to constrain sCI yields. As the length of the carbon chain increases, we observe a systematic increase in Criegee Intermediate stabilization at a given pressure, along with a systematic decrease in the low-pressure limit. Our results also suggest that for these symmetrical systems the anticonformer of the Criegee Intermediate stabilizes before (at lower pressure than) the syn conformer.

Pressure-Dependent Criegee Intermediate Stabilization from Alkene Ozonolysis.

We explored the pressure dependence of acetone oxide (stabilized Criegee Intermediate, sCI) formation from 2,3-dimethyl-2-butene ozonolysis between 50 and 900 Torr using a new, highly accurate technique. We exploited the ability of the sCI to oxidize SO2 to H2SO4, which we measured with a chemical ionization mass spectrometer. We produced the Criegee intermediates (CI) in a high-pressure flow reactor via ozonolysis of 2,3-dimethyl-2-butene (tetramethyl ethylene, TME) and measured the relative H2SO4 concentrations with and without an added OH scavenger. Because the TME reaction with ozone forms acetone oxide (a syn-CI) with unit efficiency, we directly calculated the sCI yields at different pressures from the precisely measured ratio of the uncalibrated H2SO4 signal with and without the scavenger. We observed a linear pressure dependence between 50 and 900 Torr with a minimum stabilization of 12.7 ± 0.6% at 50 Torr and a maximum stabilization of 42 ± 2% at 900 Torr. A linear fit to the measured data points shows a zero-pressure intercept of 15 ± 2%, constraining the fraction of CI formed below the barrier for acetone oxide isomerization.

Physical Fitness and Hormonal Profile During an 11-Week Paratroop Training Period.

Physical fitness and serum hormone concentrations have been shown to change during military training. The purpose was to examine these chronic changes in paratroopers (n = 52 male conscripts) during an 11-week training period, including acute changes induced by strenuous 5-day military field training. Hormonal profiles, body mass, maximal strength, muscle endurance, and 12-minute running test were assessed at several time points during paratrooper training. In the latter part of the training period, conscripts were involved in strenuous military field training (5 days). At week 7, during specialized military training period, aerobic performance decreased (3,146 ± 163 m) but recovered back to a baseline level (3,226 ± 190 m) at the end of the study period (p < 0.001). Standing long jump decreased at week 7 (242 ± 13 cm) (p < 0.001) from the baseline value (248 ± 13 cm), whereas push-up (52 ± 11, 60 ± 13 repetitions per minute) and sit-up (54 ± 6, 56 ± 7 repetitions per minute) performances increased (p < 0.001). No changes were observed in maximal strength and body composition, neither mostly in hormone concentrations, although cortisol decreased but increased back to baseline value at the end of the study period (p ≤ 0.05). Acute responses after the 5-day military field training included decreased maximal strength of the lower extremities and body mass, as well as changes in androgen hormone concentrations ([INCREMENT]testosterone: -46%, [INCREMENT]insulin-like growth factor-1: -28%, [INCREMENT]sex hormone-binding globulin: +25%) compared with all other measurements (p ≤ 0.05). The first 4 weeks of parachute military training decreased maximal aerobic capacity and neuromuscular performance of the lower body, whereas muscular endurance increased. Moreover, 5-day military field training resulted in dramatic changes in hormone concentrations. These findings highlight the importance of periodizing paratrooper training and underline the need for sufficient recovery immediately after military field training.

Effects of Added Resistance Training on Physical Fitness, Body Composition, and Serum Hormone Concentrations During Eight Weeks of Special Military Training Period.

A high volume of military training has been shown to compromise muscle strength development. We examined effects of added low-volume resistance training during special military training (ST) period, which took place after basic training period. Male conscripts (n = 25) were assigned to standardized ST with added resistance training group (TG, n = 13) and group with standardized ST only (control) (CG, n = 12). Standardized ST with added resistance training group performed 2 resistance training sessions per week for 8 weeks: hypertrophic strength (weeks 1-3), maximal strength (weeks 4-6) and power training (weeks 7-8). Maximal strength tests, load carriage performance (3.2 km, 27 kg), and hormone concentrations were measured before and after ST (mean ± SD). Both groups improved similarly in their load carriage performance time (TG: 1,162 ± 116 seconds vs. 1,047 ± 81 seconds; CG: 1,142 ± 95 seconds vs. 1,035 ± 81 seconds) (p < 0.001) but decreased maximal strength of the lower extremities (TG: 5,250 ± 1,110 N vs. 4,290 ± 720 N; CG: 5,170 ± 1,050 N vs. 4,330 ± 1,230 N) and back muscles (TG: 4,290 ± 990 N vs. 3,570 ± 48 N; CG: 3,920 ± 72 N vs. 3,410 ± 53 N) (p ≤ 0.05). Maximal strength of the upper extremities improved in CG (1,040 ± 200 N vs. 1,140 ± 200 N) (p ≤ 0.05) but not in TG. Maximal strength of the abdominal muscles improved in TG (3,260 ± 510 N vs. 3,740 ± 75 N) (p ≤ 0.05) but not in CG. Testosterone concentration increased in CG (15.2 ± 3.6 nmol·L⁻¹ vs. 21.6 ± 5.0 nmol·L⁻¹) (p < 0.01) but not in TG (18.6 ± 4.3 nmol·L⁻¹ vs. 19.5 ± 9.4 nmol·L⁻¹). In conclusion, interference with strength gains might be related to the high volume of aerobic activities and too low volume of resistance training during ST. To develop strength characteristics, careful periodization and individualization should be adopted in ST.

Hormonal Responses to Active and Passive Recovery After Load Carriage.

Military operations often induce fatigue resulting from load carriage. Recovery promotes military readiness. This study investigated the acute effects of AR vs. PR after load carriage on maximal isometric leg extension force (MVC) and serum hormonal concentrations. Male reservists (27 ± 3 years, 180 ± 7 cm, 74 ± 11 kg, V[Combining Dot Above]O2max 64 ± 9 ml·kg⁻¹·min⁻¹) completed PR (n = 8) or AR (n = 8) after 50 minutes of loaded (16 kg) uphill (gradient 4.0%) treadmill marching at individual anaerobic threshold. No differences were observed between groups in relative changes in MVC during the marching loading, after AR or PR or the next morning. Significant differences in relative responses to AR and PR postmarching loading were observed in serum testosterone (T), cortisol, and sex-hormone binding globulin immediately post AR and PR; however the next morning, all serum hormone concentrations had returned to normal. This study did not reveal any significant differences between the effects of AR and PR after an hour-long marching protocol at approximately anaerobic threshold on MVC or serum hormones the morning after the experimental marching protocol. Thus, based on the variable measured in this study, marching performed by physically fit army reservists at an intensity at or below anaerobic threshold may not necessitate specialized recovery protocols.

Age at diagnosis predicts local recurrence in women treated with breast-conserving surgery and postoperative radiation therapy for ductal carcinoma in situ: a population-based outcomes analysis.

PURPOSE: The main goal of treating ductal carcinoma in situ (dcis) is to prevent the development of invasive breast cancer. Most women are treated with breast-conserving surgery (bcs) and radiotherapy. Age at diagnosis may be a risk factor for recurrence, leading to concerns that additional treatment may be necessary for younger women. We report a population-based study of women with dcis treated with bcs and radiotherapy and an evaluation of the effect of age on local recurrence (lr). METHODS: All women diagnosed with dcis in Ontario from 1994 to 2003 were identified. Treatments and outcomes were collected through administrative databases and validated by chart review. Women treated with bcs and radiotherapy were included. Survival analyses were performed to evaluate the effect of age on outcomes. RESULTS: We identified 5752 cases of dcis; 1607 women received bcs and radiotherapy. The median follow-up was 10.0 years. The 10-year cumulative lr rate was 27% for women younger than 45 years, 14% for women 45-50 years, and 11% for women more than 50 years of age (p < 0.0001). The 10-year cumulative invasive lr rate was 22% for women younger than 45 years, 10% for women 45-50 years, and 7% for women more than 50 years of age (p < 0.0001). On multivariate analyses, young age (<45 years) was significantly associated with lr and invasive lr [hazard ratio (hr) for lr: 2.6; 95% confidence interval (ci): 1.9 to 3.7; p < 0.0001; hr for invasive lr: 3.0; 95% ci: 2.0 to 4.4; p < 0.0001]. An age of 45-50 years was also significantly associated with invasive lr (hr: 1.6; 95% ci: 1.0 to 2.4; p = 0.04). CONCLUSIONS: Age at diagnosis is a strong predictor of lr in women with dcis after treatment with bcs and radiotherapy.

Renal oncocytoma with invasive histopathologic features -  case report.

BACKGROUND: Renal oncocytoma is an uncommon tumor, classified as a benign renal neoplasm in the World Health Organisation classification of renal tumours. Despite it there were described several reports with invasive histopathologic features. CASE REPORT: We describe a case of renal oncocytoma with bizzare cells and invasion of renal sinus fat tissue. We performed immunohistochemical analysis of the case and a review of relevant literature. CONCLUSION: In order to set up the right dia-gnosis the perfect co- operation of clinicians and pathologists is necessary. In our opinion, in accordance with other authors, the renal oncocytomas should be considered as having a very low rather than no malignant potential, in spite of clinically benign behavior, supplementing a hypothesis, whether renal oncocytomas may be considered as a precancerous lesion of chromophobe carcinoma.

Type VI Collagen Deficiency Causes Enhanced Periodontal Tissue Destruction.

The periodontal ligament (PDL) is a fibrillar connective tissue that lies between the alveolar bone and the tooth and is composed of highly specialized extracellular matrix (ECM) molecules and a heterogeneous population of cells that are responsible for collagen formation, immune response, bone formation, and chewing force sensation. Type VI collagen (COL6), a widely distributed ECM molecule, plays a critical role in the structural integrity and mechanical properties of various tissues including muscle, tendon, bone, cartilage, and skin. However, its role in the PDL remains largely unknown. Our study shows that deficiency of COL6 impairs PDL fibrillogenesis and exacerbates tissue destruction in ligature-induced periodontitis (LIP). We found that COL6-deficient mice exhibited increased bone loss and degraded PDL in LIP and that fibroblasts expressing high levels of Col6α2 are pivotal in ECM organization and cell-ECM interactions. Moreover, COL6 deficiency in the PDL led to an increased number of fibroblasts geared toward the inflammatory response. We also observed that cultured COL6-deficient fibroblasts from the PDL exhibited decreased expression of genes related to collagen fiber turnover and ECM organization as well as migration and proliferation. Our findings suggest that COL6 plays a crucial role in the PDL, influencing fibroblast function in fibrillogenesis and affecting the immune response in periodontitis. These insights advance our understanding of the molecular mechanisms underlying PDL maturation and periodontal disease.

Effects of male paratroopers' initial body composition on changes in physical performance and recovery during a 20-day winter military field training.

Changes in physiological markers and physical performance in relation to paratroopers' initial body composition were investigated during a 20-day winter military field training (MFT) and the subsequent 10-day recovery period. Body composition, serum hormone concentrations and enzymatic biomarkers, and physical performance of 58 soldiers were measured before, during, and after MFT. Comparisons were done according to soldiers' body fat percentage before MFT between low-fat (<12% body fat) and high-fat (>12% body fat) groups. Correlations between body fat percentage preceding MFT and changes in muscle mass, physical performance, and serum hormone concentrations and enzymatic biomarkers were investigated. It was hypothesized that soldiers with a higher fat percentage would have smaller decrements in muscle mass, physical performance, and serum testosterone concentration. The change in muscle and fat mass was different between groups (p < 0.001) as the low-fat group lost 0.8 kg of muscle mass and 2.0 kg of fat mass, while there was no change in muscle mass and a loss of 3.7 kg of fat mass in the high-fat group during MFT. Fat percentage before MFT correlated with the changes in muscle mass (R2 = 0.26, p < 0.001), serum testosterone concentration (R2 = 0.22, p < 0.001), and evacuation test time (R2 = 0.10, p < 0.05) during MFT. The change in muscle mass was correlated with the changes in evacuation test time (R2 = 0.11, p < 0.05) and countermovement jump test results (R2 = 0.13, p < 0.01) during MFT. Soldiers with a higher initial fat percentage lost less muscle mass, and had smaller decrements in some aspects of physical performance, as well as in serum testosterone concentration during MFT.

Lower-body muscular power predicts performance on urban combat simulation.

BACKGROUND: Military operations in urban environments requires faster movements and therefore may place greater demands on soldier strength and anaerobic ability. OBJECTIVE: The aim was to study how physical fitness and body composition are associated with occupational test for urban combat soldiers before and after a 5-day military field exercise (MFE). METHODS: Twenty-six conscripts (age = 20±1 yrs.) volunteered, of which thirteen completed the study. Occupational performance was determined by using the newly developed Urban Combat Simulation test (UCS); which included 50-m sprinting, moving a truck tire (56 kg) 2 meters with a sledgehammer, a 12-m kettlebell carry (2×20 kg) up the stairs with a 3-m ascent, 4-time sandbag lifts (20 kg) with obstacle crossing, and a 20-m mannequin (85 kg) drag. Aerobic and muscle fitness, as well as anaerobic capacity were measured, and, body composition was assessed with multifrequency bioimpedance analysis. RESULTS: The UCS performance correlated significantly with standing long jump performance, as well as lower and upper body maximal strength before (r = -0.56 to -0.66) and after (r = -0.59 to -0.68) MFE, and, with body mass and FFM before (r = -0.81 to -0.83) and after (r = -0.86 to -0.91) MFE. In the regression analyses, fat free mass (R2 = 0.50, p = 0.01) and counter movement jump in combat load (R2 = 0.46, p = 0.009) most strongly explained the UCS performance. CONCLUSION: This study demonstrated that muscle mass and lower body explosive force production together with maximal strength are key fitness components related to typical urban combat soldiers' military tasks. Physical training developing these components are recommended.

Is device-measured physical activity associated with musculoskeletal disorders among young adult Finnish men?

Background: Musculoskeletal (MSK) disorders represent a significant burden to society and can be unpleasant for the affected individuals. Physical activity (PA) can prevent MSK disorders while conferring other health benefits. The present study aimed to investigate associations between device-measured PA and perceived MSK disorders among young adult men. Methods: PA at different intensity levels, standing, and sedentary behavior were measured with a hip-worn accelerometer in a cohort of 422 young adult Finnish men aged 26 years on average. The incidences of three common MSK disorders (viz., knee pain, lumbar radicular pain, and lumbago pain) during the last month were inquired by a questionnaire. Binary logistic regression was used to examine the associations between the MSK outcomes and explanatory PA variables (PA times at different intensity levels, standing, and sedentary times). The models were controlled for age, education, smoking, BMI, and maximal oxygen uptake. Results: PA, standing, and sedentary times were not significantly associated with the incidence of perceived MSK pain during the last month, except for lumbago pain. Lumbago pain was slightly more probable if the time spent in light PA increased, even after controlling for potential confounding factors, including moderate-to-vigorous PA, with an odds ratio (OR) of 1.07 (95% CI: 1.02-1.14). Sedentary time showed an opposite association, with an OR of 0.98 (95% CI: 0.96-1.00). Conclusions: There were neither positive nor negative clinically meaningful associations between PA and recent MSK disorders among young adult men. The result is surprising and requires further confirmation.

Exercise self-efficacy remains unaltered during military service.

Background: Exercise self-efficacy is a crucial aspect of adopting and maintaining a physically active lifestyle. Regular physical activity may enhance exercise self-efficacy. This study aimed to investigate the baseline associations of physical fitness, physical activity, and body composition with exercise self-efficacy and the effects of military service on exercise self-efficacy. Methods: The sample consisted of healthy young Finnish conscripts (n = 243) undergoing military service. The participants were divided into two groups: an intervention group undergoing a high-intensity functional training program (n = 113) and a control group undergoing traditional physical training within their military service (n = 130). Exercise self-efficacy (adoption and barrier) and aerobic and muscular fitness were measured thrice (baseline, month 3, and month 5). Self-reported leisure-time physical activity and measured fat percentage were collected at baseline. Results: Adoption and barrier exercise self-efficacy correlated positively with aerobic and muscular fitness and leisure time physical activity (r = 0.33-0.59, p < 0.001), and barrier self-efficacy negatively with fat percentage (r = -0.15, p < 0.05) at baseline. No changes in adoption (time p = 0.912) and barrier self-efficacy (time p = 0.441) occurred during the military service. There were no differences between groups in these changes (group × time interaction p = 0.643 for adoption self-efficacy and p = 0.872 for barrier self-efficacy). Change in muscular fitness correlated positively with change in barrier self-efficacy in the high-intensity functional training group (r = 0.35, p < 0.05). Conclusions: Exercise self-efficacy is positively associated with physical fitness and physical activity among young males. However, military service, whether it involves high-intensity functional physical training or more diverse traditional physical training, does not improve exercise self-efficacy.

Serum concentration of immunoglobulin G-type antibodies against the whole Epstein-Barr nuclear antigen 1 and its aa35-58 or aa398-404 fragments in the sera of patients with systemic lupus erythematosus and multiple sclerosis.

Several studies suggest that infection by Epstein-Barr virus (EBV) might be one of the environmental factors which facilitates the development of autoimmune disorders in genetically susceptible individuals. Recent data indicate that high anti-Epstein-Barr nuclear antigen 1 (EBNA)-1 immunoglobulin (Ig)G titre is a strong risk factor for multiple sclerosis (MS) in patients both with and without the main genetic predisposing trait, human leucocyte antigen (HLA)-DRB1*15:01. Because no similar studies have been published in systemic lupus erythematosus (SLE) patients, we determined the HLA-DRB1*15:01 carrier state and the serum titres against the whole EBNA-1 and its small fragments aa35-58 and aa398-404 in 301 SLE patients, 135 MS patients and in 345 healthy controls. The carrier state of the HLA-DRB1*15:01 allele was deduced from genotyping of a tagSNP (rs3135388) by applying a Taqman-based assay. The serum concentrations of antibodies to EBNA-1 and its aa35-58 or aa398-404 fragments were determined using a commercial assay (ETI-EBNA-G) and home-made enzyme-linked immunosorbent assays, respectively. The serum concentration of anti-EBNA-1 antibodies was significantly (P < 0·001) higher both in MS and SLE patients than in controls. Similar significant differences were found both in HLA-DRB1*15:01 carriers and non-carriers. Furthermore, titres of antibodies against the aa35-58 EBNA-1 fragment were elevated both in MS and SLE patients. By contrast, the levels of aa398-404 EBNA-1 antibodies were elevated significantly only in the SLE patients. These findings indicate that high anti-EBNA-1 IgG titres are HLA-DRB1*15:01-independent risk factors not only for MS, but also for SLE, while high antibody titres against the aa398-404 fragment are characteristic for SLE.

Prognostic impact of pretransplant iron overload measured with magnetic resonance imaging on severe infections in allogeneic stem cell transplantation.

OBJECTIVE: Infections and graft-versus-host disease (GVHD) are the main causes of transplant-related mortality (TRM) of patients undergoing allo-SCT. The role of iron overload (IO) has been debated in this context. Studies, performed with non-specific surrogate markers of iron, suggest that IO predicts poor outcome after allo-SCT. METHODS: In this prospective study, we quantified pretransplant IO with MRI-based hepatic iron concentration (HIC) measurement; the degree of IO was used to predict infections, GVHD, and mortality after allo-SCT. Logistic univariate, multivariate, and Cox's regression analyses were performed. RESULTS: Iron overload was present in 78% of the patients (HIC>36 µmol/g). The median HIC was 98 µmol/g (range 5-348). There were no cases of cardiac iron excess. IO was significantly associated with severe infections during the early post-transplant period (for every 10 µmol/g increase OR: 1.15, 95% CI 1.05-1.26, P = 0.003). The odds for severe infections increased 6.5- (>125 µmol/g OR: 6.5, P = 0.013) to 14-fold (>269 µmol/g OR: 14.1, P = 0.040) with increasing HIC. IO was found to be associated with reduced risk of acute and chronic GVHD. Although TRM was due to infection-related deaths, IO was not associated with TRM or OS. CONCLUSION: Pretransplant IO, measured with a direct MRI-based measurement, predicts severe infections in the early post-transplant period.