Integração entre assistência farmacêutica e vigilância epidemiológica no contexto das ações do programa estadual de controle da tuberculose do Rio Grande do Sul / Integration between pharmaceutical services and epidemiological surveillance in the context of the actions of the state tuberculosis control program in Rio Grande do Sul

Este trabalho visa avaliar a adequação do armazenamento e da distribuição dos medicamentos nos seis primeiros meses de implantação da integração entre a assistência farmacêutica do Hospital Sanatório Partenon (HSP) e a vigilância epidemiológica no contexto do Programa Estadual de Controle da Tuberculose (PECTRS). (AU)

The sesquiterpenes polygodial and drimanial in vitro affect glutamatergic transport in rat brain.

Natural products including those derived from plants, have over the years greatly contributed to the development of therapeutic drugs. Polygodial and drimanial are sesquiterpenes isolated from the bark of the plant Drymis Winteri (Winteraceae) that exhibit antinociceptive properties. Since peripheral glutamate presents nociceptive actions, in this study it was investigated the effects of hydroalcooholic extracts from Drymis winteri (polygodial and drimanial) on the glutamatergic system in rat brain. Polygodial and drimanial inhibited glutamate uptake by astrocytes, as well as by cortical, hippocampal and striatal slices, and increased synaptosomal glutamate release. These concurrent effects would predispose to an increase in the extracellular glutamate concentrations, leading to possible neurotoxic effects (excitotoxicity) of these natural compounds, which would suggest the need for some caution in their therapeutic application.