Detalhe da pesquisa
1.
An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern.
Bioorg Med Chem
; 38: 116130, 2021 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33848699
2.
Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.
Bioorg Chem
; 76: 380-385, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29241110
3.
Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.
Bioorg Med Chem
; 25(1): 233-240, 2017 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27818030
4.
The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Med Res Rev
; 36(5): 924-63, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27192495
5.
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core.
Bioorg Med Chem
; 24(16): 3540-7, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27316545
6.
Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.
J Comput Aided Mol Des
; 28(12): 1233-45, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25301376
7.
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.
J Med Chem
; 66(8): 5584-5610, 2023 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37027512
8.
Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML.
J Med Chem
; 66(23): 15944-15959, 2023 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37983486
9.
Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis.
Eur J Med Chem
; 238: 114423, 2022 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35544982
10.
Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.
J Med Chem
; 65(6): 5029-5043, 2022 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35253427
11.
Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials.
Perioper Med (Lond)
; 10(1): 32, 2021 Sep 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34538277
12.
Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications.
Free Radic Biol Med
; 168: 129-141, 2021 05 20.
Artigo
Inglês
| MEDLINE | ID: mdl-33794311
13.
Discovery of 3,5-Dimethyl-4-Sulfonyl-1H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability.
J Med Chem
; 64(15): 11330-11353, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34342996
14.
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
Eur J Med Chem
; 207: 112734, 2020 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32866756
15.
Myeloid cell leukemin-1 inhibitors: a growing arsenal for cancer therapy.
Drug Discov Today
; 25(10): 1873-1882, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32771436
16.
Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown.
J Med Chem
; 63(9): 4644-4654, 2020 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32153174
17.
Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
Eur J Med Chem
; 202: 112532, 2020 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32668381
18.
Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
J Med Chem
; 63(19): 11149-11168, 2020 10 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32902980
19.
Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
Eur J Med Chem
; 188: 112027, 2020 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31923859
20.
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy.
J Med Chem
; 62(8): 3840-3856, 2019 04 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30444366