Detalhe da pesquisa
1.
Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo.
Clin Sci (Lond)
; 135(15): 1897-1914, 2021 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34318878
2.
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIß Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity.
J Pharmacol Exp Ther
; 373(3): 402-415, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32253261
3.
In vitro and in vivo investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline.
Clin Sci (Lond)
; 133(16): 1827-1844, 2019 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-31409729
4.
Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart.
J Pharmacol Exp Ther
; 364(3): 433-446, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29273587
5.
Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model.
Exp Cell Res
; 339(2): 174-86, 2015 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26515555
6.
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage.
Toxicol Sci
; 198(2): 288-302, 2024 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38290791
7.
Corrigendum to: "Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model" [Exp. Cell Res. 339 2 (2015) 174-186].
Exp Cell Res
; 343(2): 267, 2016 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27155561
8.
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIß Interactions.
J Med Chem
; 64(7): 3997-4019, 2021 04 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33750129
9.
Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIß inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity.
Sci Rep
; 11(1): 4456, 2021 02 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33627707
10.
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation.
Circ Heart Fail
; 14(11): e008209, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34551586
11.
UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study.
Sci Rep
; 9(1): 4524, 2019 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30872754
12.
Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite.
Toxicology
; 392: 1-10, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28941780
13.
Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.
Toxicology
; 371: 17-28, 2016 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27744045
14.
Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.
Toxicology
; 350-352: 15-24, 2016 03 28.
Artigo
Inglês
| MEDLINE | ID: mdl-27046792
15.
In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.
PLoS One
; 10(10): e0139929, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26460540
16.
Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.
Free Radic Biol Med
; 74: 210-21, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-24992833
17.
Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.
PLoS One
; 9(11): e112059, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25393531