Detalhe da pesquisa
1.
Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists.
Bioorg Med Chem Lett
; 26(12): 2866-2869, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27161805
2.
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Bioorg Med Chem Lett
; 23(12): 3640-5, 2013 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23652221
3.
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
Bioorg Med Chem Lett
; 21(2): 869-73, 2011 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21195616
4.
Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose.
Front Pharmacol
; 12: 786078, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-35002718
5.
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
J Pharmacol Exp Ther
; 334(2): 545-55, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20439438
6.
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorg Med Chem Lett
; 20(18): 5480-3, 2010 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20709545
7.
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorg Med Chem Lett
; 20(18): 5536-40, 2010 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20709552
8.
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorg Med Chem Lett
; 20(24): 7479-82, 2010 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21106456
9.
Antinociceptive effects of potent, selective and brain penetrant muscarinic M4 positive allosteric modulators in rodent pain models.
Brain Res
; 1737: 146814, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32234514
10.
The role of melanin-concentrating hormone-1 receptors in the voiding reflex in rats.
J Pharmacol Exp Ther
; 328(1): 165-73, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18849359
11.
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorg Med Chem Lett
; 18(5): 1696-701, 2008 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18243692
12.
Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist.
Neuropharmacology
; 50(7): 865-73, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16464480
13.
Discovery of Vibegron: A Potent and Selective ß3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
J Med Chem
; 59(2): 609-23, 2016 Jan 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26709102
14.
Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain.
J Pain
; 6(7): 434-8, 2005 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-15993821
15.
Factor XII full and partial null in rat confers robust antithrombotic efficacy with no bleeding.
Blood Coagul Fibrinolysis
; 26(8): 893-902, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26192114
16.
Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.
ACS Med Chem Lett
; 6(5): 553-7, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26005532
17.
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit.
Mol Ther Nucleic Acids
; 4: e224, 2015 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25625614
18.
Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability.
Thromb Haemost
; 113(6): 1300-11, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25790442
19.
Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit.
Thromb Haemost
; 111(4): 694-704, 2014 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24336918
20.
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.
ACS Med Chem Lett
; 5(6): 717-21, 2014 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24944750