Detalhe da pesquisa
1.
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.
Annu Rev Biochem
; 85: 375-404, 2016 Jun 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27145840
2.
Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation.
Bioconjug Chem
; 34(9): 1679-1687, 2023 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-37657082
3.
From cultivation to cancer: formation of N-nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications.
Crit Rev Toxicol
; 53(10): 658-701, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-38050998
4.
Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells.
Int J Mol Sci
; 22(7)2021 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-33810274
5.
Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
Int J Cancer
; 147(10): 2847-2861, 2020 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32599645
6.
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.
Proc Natl Acad Sci U S A
; 113(36): E5271-80, 2016 09 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27551077
7.
Design of a molecular support for cryo-EM structure determination.
Proc Natl Acad Sci U S A
; 113(47): E7456-E7463, 2016 11 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27821763
8.
Small molecule induced reactivation of mutant p53 in cancer cells.
Nucleic Acids Res
; 41(12): 6034-44, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23630318
9.
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
Proc Natl Acad Sci U S A
; 109(42): 16906-10, 2012 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-23035244
10.
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration.
Proc Natl Acad Sci U S A
; 108(20): 8251-6, 2011 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-21525412
11.
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
Proc Natl Acad Sci U S A
; 108(2): 557-62, 2011 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-21178074
12.
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
J Med Chem
; 67(1): 674-690, 2024 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38126712
13.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
ACS Chem Biol
; 19(2): 266-279, 2024 Feb 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38291964
14.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
bioRxiv
; 2024 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38405908
15.
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.
J Med Chem
; 67(5): 3813-3842, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38422480
16.
Evaluating Drosophila p53 as a model system for studying cancer mutations.
J Biol Chem
; 287(53): 44330-7, 2012 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23135266
17.
Structural insights into a regulatory mechanism of FIR RRM1-FUSE interaction.
Open Biol
; 13(5): 230031, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37253421
18.
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction.
J Med Chem
; 66(1): 976-990, 2023 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36580549
19.
Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily.
Eur J Med Chem
; 254: 115347, 2023 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37094449
20.
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53.
J Am Chem Soc
; 134(15): 6810-8, 2012 Apr 18.
Artigo
Inglês
| MEDLINE | ID: mdl-22439615