Detalhe da pesquisa
1.
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.
Proc Natl Acad Sci U S A
; 120(21): e2221967120, 2023 05 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37186857
2.
Halide Noninnocence and Direct Photoreduction of Ni(II) Enables Coupling of Aryl Chlorides in Dual Catalytic, Carbon-Heteroatom Bond-Forming Reactions.
J Am Chem Soc
; 145(22): 12293-12304, 2023 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37204458
3.
Photoredox-Mediated, Nickel-Catalyzed Trifluoromethylthiolation of Aryl and Heteroaryl Iodides.
J Org Chem
; 87(14): 8921-8927, 2022 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35786936
4.
A Unified and Practical Method for Carbon-Heteroatom Cross-Coupling using Nickel/Photo Dual Catalysis.
Chemistry
; 26(23): 5168-5173, 2020 Apr 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32065838
5.
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Bioorg Med Chem Lett
; 28(8): 1336-1341, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29559278
6.
Mouse Red Blood Cell-Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate.
Drug Metab Dispos
; 45(12): 1345-1353, 2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28986473
7.
Photoredox Mediated Nickel Catalyzed Cross-Coupling of Thiols With Aryl and Heteroaryl Iodides via Thiyl Radicals.
J Am Chem Soc
; 138(6): 1760-3, 2016 Feb 17.
Artigo
Inglês
| MEDLINE | ID: mdl-26840123
8.
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.
Bioorg Med Chem Lett
; 26(19): 4775-4780, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27578247
9.
Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross-Coupling of Primary Aryl Amines with Aryl Halides.
Angew Chem Int Ed Engl
; 55(42): 13219-13223, 2016 10 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27436532
10.
Effects of Molecular Oxygen, Solvent, and Light on Iridium-Photoredox/Nickel Dual-Catalyzed Cross-Coupling Reactions.
J Org Chem
; 80(15): 7642-51, 2015 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26140623
11.
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Bioorg Med Chem Lett
; 25(24): 5743-7, 2015 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26546219
12.
Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases.
Bioorg Med Chem Lett
; 24(4): 1138-43, 2014 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24462666
13.
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.
Sci Signal
; 17(825): eadf2670, 2024 Feb 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38412255
14.
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
Clin Cancer Res
; 30(7): 1338-1351, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37967136
15.
Reductive Radical Conjugate Addition of Alkyl Electrophiles Catalyzed by a Cobalt/Iridium Photoredox System.
Org Lett
; 23(15): 6046-6051, 2021 08 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34270268
16.
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
J Med Chem
; 64(19): 14498-14512, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34570508
17.
Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors.
ACS Chem Biol
; 15(2): 325-333, 2020 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32017532
18.
Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis.
J Med Chem
; 63(16): 8667-8682, 2020 08 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32243158
19.
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.
J Med Chem
; 62(21): 9418-9437, 2019 11 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31361481
20.
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.
Cancer Res
; 78(23): 6691-6702, 2018 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30297535