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1.
Global Spine J ; : 21925682231167096, 2024 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-38453667

RESUMO

STUDY DESIGN: Narrative review. OBJECTIVE: The spine is the most common site of metastases, associated with decreased quality of life. Increase in metastatic spine tumour surgery (MSTS) has caused us to focus on the management of blood, as blood loss is a significant morbidity in these patients. However, blood transfusion is also not without its own risks, and hence this led to blood conservation strategies and implementation of a concept of patient blood management (PBM) in clinical practise focusing on these patients. METHODS: A narrative review was conducted and all studies that were related to blood management in metastatic spine disease as well as PBM surrounding this condition were included. RESULTS: A total of 64 studies were included in this review. We discussed a new concept of patient blood management in patients undergoing MSTS, with stratification to pre-operative and intra-operative factors, as well as anaesthesia and surgical considerations. The studies show that PBM and reduction in blood transfusion allows for reduced readmission rates, lower risks associated with blood transfusion, and lower morbidity for patients undergoing MSTS. CONCLUSION: Through this review, we highlight various pre-operative and intra-operative methods in the surgical and anaesthesia domains that can help with PBM. It is an important concept with the significant amount of blood loss expected from MSTS. LEVEL OF EVIDENCE: Not applicable.

3.
Indian J Orthop ; 52(4): 406-410, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30078900

RESUMO

BACKGROUND: Gustilo IIIB tibial fractures are associated with high rates of infection and nonunion. This study evaluates the impact of factors such as patient demographics, mechanism of injury, time to the first debridement, and time to flap coverage on the union and infection rates. MATERIALS AND METHODS: A retrospective analysis was performed on all patients with open tibial fractures who presented to our tertiary trauma center over 13 years from April 2000 to August 2013. All patients were followed for at least 6 months and continued till radiographic evidence of union (maximum 72 months). Time to fracture union was based on radiological evidence of callus bridging at least three cortices. Information on infection rates and the presence of microbes were evaluated. RESULTS: A total of 120 patients were analyzed. The mean time to fracture union was 33.8 weeks. Younger age was associated with a lower risk of nonunion with the mean age being 30.4 years in union group compared to 38.2 in the delayed-union group. Smoking was associated with an increased risk of delayed union with revision surgery being needed in 61.5% of smokers compared to 36.4% in nonsmokers. Rates of infection were high at 30.3%. Smoking was associated with an increased risk of infection (65.4% vs. 24.7%). CONCLUSION: High-energy open tibia fractures required an average of 8.5 months to heal and delayed or nonunion at an earlier juncture cannot be assumed.

4.
Artigo em Inglês | WPRIM | ID: wpr-764957

RESUMO

BACKGROUND: Limited data exist on real-world treatment patterns for diabetic macular edema (DME) in Korea. In this study, we investigated DME treatment patterns from 2009 to 2014 and the impact of baseline treatment on healthcare resource utilization and visual acuity (VA) outcomes. METHODS: A retrospective cohort chart review of DME patients treated at 11 hospital ophthalmology clinics between January 1, 2012 and December 31, 2013 was conducted. We collected data on demographics, healthcare resource utilization (clinic visits, treatment visits, and visits for ocular investigations), distribution of DME treatments, and VA. RESULTS: Overall, 522 DME patients (men, 55.2%; mean age, 59 years; mean HbA1c [n = 209], 8.4%) with 842 DME eyes were evaluated. For all treatments, healthcare resource utilization was significantly higher during the first 6 months versus months 7–12, year 2, or year 3 (P ≤ 0.001), but was highest for patients whose first treatment was an anti-vascular endothelial growth factor (VEGF) treatment (visits/quarter; anti-VEGF, 1.9; corticosteroids, 1.7; laser, 1.4). Use of macular laser therapy decreased (44% to 8%), whereas use of anti-VEGF injections increased (44% to 69%) during the study period. However, VA improvement was not commensurate with healthcare resource utilization of anti-VEGF treatment (mean VA gain, 2.7 letters). CONCLUSION: A trend toward increasing use of intravitreal anti-VEGF injections for DME treatment was observed in Korea. However, the frequency of dosing and monitoring was lower in clinical practice versus major clinical trials, which may have led to the less-than-favorable improvements in visual outcomes.


Assuntos
Humanos , Corticosteroides , Estudos de Coortes , Atenção à Saúde , Demografia , Fatores de Crescimento Endotelial , Injeções Intravítreas , Coreia (Geográfico) , Terapia a Laser , Edema Macular , Oftalmologia , Padrões de Prática Médica , Estudos Retrospectivos , Acuidade Visual
5.
Singapore medical journal ; : 224-227, 2018.
Artigo em Inglês | WPRIM | ID: wpr-687885

RESUMO

We present five patients with vibrio necrotising fasciitis, a lethal and disabling disease. Two of these patients had a history of exposure to either warm seawater or raw/live seafood, three had underlying chronic liver disease, and four presented with hypotension and fever. There were three deaths and four patients required intensive care unit stays. Among the two survivors, one had high morbidity. Only one patient met the criteria of Laboratory Risk Indicator for Necrotising Fasciitis score > 6. A clinician should suspect possible vibrio necrotising fasciitis if the following are present: contact with fresh seafood/warm seawater, a known history of chronic liver disease and pain that is out of proportion to cutaneous signs. All patients must be managed via intensive care in high dependency units. We recommend a two-step surgical protocol for patient management involving an initial local debridement, followed by a second-stage radical debridement and skin grafting.


Assuntos
Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Desbridamento , Doença Hepática Terminal , Fasciite Necrosante , Diagnóstico , Microbiologia , Cirurgia Geral , Febre , Hepatite B , Hipotensão , Estudos Retrospectivos , Fatores de Risco , Alimentos Marinhos , Água do Mar , Índice de Gravidade de Doença , Singapura , Transplante de Pele , Vibrio , Vibrioses , Diagnóstico , Cirurgia Geral
6.
Artigo em Inglês | WPRIM | ID: wpr-296469

RESUMO

<p><b>INTRODUCTION</b>Pertrochanteric fractures after low-energy trauma are common among osteoporotic patients. Although the use of intramedullary devices to treat such fractures is becoming increasingly popular, there is a paucity of data comparing the outcomes of the use of short cephalomedullary nails (SCN) with the use of long cephalomedullary nails (LCN). This study aimed to compare the outcomes of treatment using LCN with treatment using SCN for patients with osteoporotic pertrochanteric fractures.</p><p><b>METHODS</b>A retrospective review of 64 patients with osteoporotic pertrochanteric fractures who were treated with either LCN or SCN and had a minimum follow-up of one year was performed. Primary outcome measures include complications, revision surgeries and union rates. Secondary outcome measures include duration of surgery, estimated blood loss, length of hospital stay, and ambulatory and mortality status at one year.</p><p><b>RESULTS</b>There was no significant difference in the clinical and functional outcomes of the patients who were treated with LCN and those who were treated with SCN. However, there was a higher incidence of heterotopic ossification in the latter group, and a slightly greater average estimated blood loss and duration of surgery in the former group. Patients treated with LCN tended to be more osteoporotic.</p><p><b>CONCLUSION</b>Our study found no significant difference in terms of complications, revision surgeries, union rates and ambulatory status between the patients who were treated with LCN and those who were treated with SCN. Both LCN and SCN provided safe and reliable outcomes in the treatment of osteoporotic pertrochanteric fractures.</p>


Assuntos
Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pinos Ortopédicos , Fraturas do Fêmur , Cirurgia Geral , Fixação Intramedular de Fraturas , Fraturas do Quadril , Cirurgia Geral , Incidência , Tempo de Internação , Fraturas por Osteoporose , Cirurgia Geral , Complicações Pós-Operatórias , Reoperação , Estudos Retrospectivos , Resultado do Tratamento
7.
Artigo em Inglês | WPRIM | ID: wpr-962027

RESUMO

@#Retained rectal foreign body, with its associated social stigma, is a medical condition that is infrequently reported in Malaysia. We report the surgical management of five cases of retained foreign objects in the rectum seen over a one-year period. There were three young and two elderly male patients. One of the elderly patients presented with altered bowel habits and an abdominal mass that mimicked a symptomatic colonic tumor. All patients had an abdominal radiograph which clinched the diagnosis of a retained foreign rectal body. Successfully retrieved objects included two bottles, one bidet device, and two sex toys. Open surgery for retrieval of the impacted rectal foreign body was required in one patient. All underwent successful retrievals without any adverse postoperative complications. In our case series, retained rectal foreign bodies were observed only in the male gender. The age presentation was bimodal, with age groups in the twenties and sixties. The treatment options used for the retrieval of these impacted foreign bodies included transanal extraction or explorative laparotomy. Proximal migration and delayed presentation are possible indications for the latter approach.

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