Detalhe da pesquisa
1.
The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration.
Drug Metab Dispos
; 51(10): 1419-1427, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37429728
2.
Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7.
Bioorg Med Chem Lett
; 50: 128320, 2021 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34400299
3.
Molecular hybridization yields triazole bronchodilators for the treatment of COPD.
Bioorg Med Chem Lett
; 25(22): 5121-6, 2015 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26471092
4.
Relationship between repeated sprint ability and aerobic capacity in professional soccer players.
ScientificWorldJournal
; 2013: 952350, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-24198732
5.
A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats.
Xenobiotica
; 42(1): 75-85, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22077102
6.
Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity.
Xenobiotica
; 42(1): 86-93, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22106935
7.
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Bioorg Med Chem Lett
; 21(21): 6596-602, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21920751
8.
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Bioorg Med Chem Lett
; 21(21): 6591-5, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21955944
9.
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.
Bioorg Med Chem Lett
; 21(19): 5826-30, 2011 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21880489
10.
Inhalation by design: dual pharmacology ß-2 agonists/M3 antagonists for the treatment of COPD.
Bioorg Med Chem Lett
; 21(9): 2759-63, 2011 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21075627
11.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34663813
12.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32935104
13.
The sulfonamide group as a structural alert: A distorted story?
Curr Opin Drug Discov Devel
; 11(1): 72-9, 2008 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18175269
14.
Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.
Bioorg Med Chem Lett
; 18(4): 1284-7, 2008 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18243699
15.
Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.
J Med Chem
; 61(8): 3685-3696, 2018 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-29627981
16.
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J Med Chem
; 60(2): 767-786, 2017 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-27983835
17.
Effects of competition on the sleep patterns of elite rugby union players.
Eur J Sport Sci
; 15(8): 681-6, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26255667
18.
Measuring Recovery in Elite Rugby Players: The Brief Assessment of Mood, Endocrine Changes, and Power.
Res Q Exerc Sport
; 86(4): 379-86, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26288253
19.
An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
J Med Chem
; 54(1): 67-77, 2011 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21128663
20.
Inhalation by design: novel ultra-long-acting ß(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.
J Med Chem
; 53(18): 6640-52, 2010 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-20804199