Pesquisa | Secretaria de Estado da Saúde

1.

Activation of naïve CD4⁺ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4⁺ T cells.

Twohig, Jason P; Cardus Figueras, Ana; Andrews, Robert; Wiede, Florian; Cossins, Benjamin C; Derrac Soria, Alicia; Lewis, Myles J; Townsend, Michael J; Millrine, David; Li, Jasmine; Hill, David G; Uceda Fernandez, Javier; Liu, Xiao; Szomolay, Barbara; Pepper, Christopher J; Taylor, Philip R; Pitzalis, Costantino; Tiganis, Tony; Williams, Nigel M; Jones, Gareth W; Jones, Simon A.

Nat Immunol ; 20(4): 458-470, 2019 04.

Artigo Inglês | MEDLINE | ID: mdl-30890796

2.

Corrigendum: IL-6 as a keystone cytokine in health and disease.

Hunter, Christopher A; Jones, Simon A.

Nat Immunol ; 18(11): 1271, 2017 10 18.

Artigo Inglês | MEDLINE | ID: mdl-29044237

3.

Trial of N-Acetyl-l-Leucine in Niemann-Pick Disease Type C.

Bremova-Ertl, Tatiana; Ramaswami, Uma; Brands, Marion; Foltan, Tomas; Gautschi, Matthias; Gissen, Paul; Gowing, Francesca; Hahn, Andreas; Jones, Simon; Kay, Richard; Kolnikova, Miriam; Arash-Kaps, Laila; Marquardt, Thorsten; Mengel, Eugen; Park, Julien H; Reichmannová, Stella; Schneider, Susanne A; Sivananthan, Siyamini; Walterfang, Mark; Wibawa, Pierre; Strupp, Michael; Martakis, Kyriakos.

N Engl J Med ; 390(5): 421-431, 2024 Feb 01.

Artigo Inglês | MEDLINE | ID: mdl-38294974

4.

IL-6 as a keystone cytokine in health and disease.

Hunter, Christopher A; Jones, Simon A.

Nat Immunol ; 16(5): 448-57, 2015 May.

Artigo Inglês | MEDLINE | ID: mdl-25898198

5.

On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier.

Dutzan, Nicolas; Abusleme, Loreto; Bridgeman, Hayley; Greenwell-Wild, Teresa; Zangerle-Murray, Tamsin; Fife, Mark E; Bouladoux, Nicolas; Linley, Holly; Brenchley, Laurie; Wemyss, Kelly; Calderon, Gloria; Hong, Bo-Young; Break, Timothy J; Bowdish, Dawn M E; Lionakis, Michail S; Jones, Simon A; Trinchieri, Giorgio; Diaz, Patricia I; Belkaid, Yasmine; Konkel, Joanne E; Moutsopoulos, Niki M.

Immunity ; 46(1): 133-147, 2017 01 17.

Artigo Inglês | MEDLINE | ID: mdl-28087239

6.

Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements.

Millrine, David; Cardus Figueras, Ana; Uceda Fernandez, Javier; Andrews, Robert; Szomolay, Barbara; Cossins, Benjamin C; Rice, Christopher M; Li, Jasmine; Tyrrell, Victoria J; McLeod, Louise; Holmans, Peter; O'Donnell, Valerie B; Taylor, Philip R; Turner, Stephen J; Jenkins, Brendan J; Jones, Gareth W; Topley, Nicholas; Williams, Nigel M; Jones, Simon A.

J Immunol ; 211(2): 274-286, 2023 07 15.

Artigo Inglês | MEDLINE | ID: mdl-37272871

7.

A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype.

Occelli, Laurence M; Daruwalla, Anahita; De Silva, Samantha R; Winkler, Paige A; Sun, Kelian; Pasmanter, Nathaniel; Minella, Andrea; Querubin, Janice; Lyons, Leslie A; Robson, Anthony G; Heon, Elise; Michaelides, Michel; Webster, Andrew R; Palczewski, Krzysztof; Vincent, Ajoy; Mahroo, Omar A; Kiser, Philip D; Petersen-Jones, Simon M.

Hum Mol Genet ; 31(8): 1263-1277, 2022 04 22.

Artigo Inglês | MEDLINE | ID: mdl-34726233

8.

Hematopoietic Stem- and Progenitor-Cell Gene Therapy for Hurler Syndrome.

Gentner, Bernhard; Tucci, Francesca; Galimberti, Stefania; Fumagalli, Francesca; De Pellegrin, Maurizio; Silvani, Paolo; Camesasca, Chiara; Pontesilli, Silvia; Darin, Silvia; Ciotti, Francesca; Sarzana, Marina; Consiglieri, Giulia; Filisetti, Chiara; Forni, Giulia; Passerini, Laura; Tomasoni, Daniela; Cesana, Daniela; Calabria, Andrea; Spinozzi, Giulio; Cicalese, Maria-Pia; Calbi, Valeria; Migliavacca, Maddalena; Barzaghi, Federica; Ferrua, Francesca; Gallo, Vera; Miglietta, Simona; Zonari, Erika; Cheruku, Patali S; Forni, Claudia; Facchini, Marcella; Corti, Ambra; Gabaldo, Michela; Zancan, Stefano; Gasperini, Serena; Rovelli, Attilio; Boelens, Jaap-Jan; Jones, Simon A; Wynn, Robert; Baldoli, Cristina; Montini, Eugenio; Gregori, Silvia; Ciceri, Fabio; Valsecchi, Maria G; la Marca, Giancarlo; Parini, Rossella; Naldini, Luigi; Aiuti, Alessandro; Bernardo, Maria-Ester.

N Engl J Med ; 385(21): 1929-1940, 2021 11 18.

Artigo Inglês | MEDLINE | ID: mdl-34788506

9.

Improving newborn screening test performance for metachromatic leukodystrophy: Recommendation from a pre-pilot study that identified a late-infantile case for treatment.

Wu, Teresa H Y; Brown, Heather A; Church, Heather J; Kershaw, Christopher J; Hutton, Rebekah; Egerton, Christine; Cooper, James; Tylee, Karen; Cohen, Rebecca N; Gokhale, David; Ram, Dipak; Morton, Georgina; Henderson, Michael; Bigger, Brian W; Jones, Simon A.

Mol Genet Metab ; 142(1): 108349, 2024 May.

Artigo Inglês | MEDLINE | ID: mdl-38458124

10.

Land surface conductance linked to precipitation: Co-evolution of vegetation and climate in Earth system models.

Franks, Peter J; Herold, Nicholas; Bonan, Gordon B; Oleson, Keith W; Dukes, Jeffrey S; Huber, Matthew; Schroeder, Julian I; Cox, Peter M; Jones, Simon.

Glob Chang Biol ; 30(3): e17188, 2024 Mar.

Artigo Inglês | MEDLINE | ID: mdl-38462677

11.

Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study.

Odd, David; Sabir, Hemmen; Jones, Simon A; Gale, Chris; Chakkarapani, Ela.

Pediatr Res ; 2024 Apr 02.

Artigo Inglês | MEDLINE | ID: mdl-38565915

12.

Long-term benefit of sotorasib in patients with KRAS G12C-mutated non-small-cell lung cancer: plain language summary.

Dy, Grace K; Govindan, Ramaswamy; Velcheti, Vamsidhar; Falchook, Gerald S; Italiano, Antoine; Wolf, Jürgen; Sacher, Adrian G; Takahashi, Toshiaki; Ramalingam, Suresh S; Dooms, Christophe; Kim, Dong-Wan; Addeo, Alfredo; Desai, Jayesh; Schuler, Martin; Tomasini, Pascale; Hong, David S; Lito, Piro; Tran, Qui; Jones, Simon; Anderson, Abraham; Hindoyan, Antreas; Snyder, Wendy; Skoulidis, Ferdinandos; Li, Bob T.

Future Oncol ; 20(3): 113-120, 2024 Jan.

Artigo Inglês | MEDLINE | ID: mdl-38010044

13.

Development of a translatable gene augmentation therapy for CNGB1-retinitis pigmentosa.

Occelli, Laurence M; Zobel, Lena; Stoddard, Jonathan; Wagner, Johanna; Pasmanter, Nathaniel; Querubin, Janice; Renner, Lauren M; Reynaga, Rene; Winkler, Paige A; Sun, Kelian; Marinho, Luis Felipe L P; O'Riordan, Catherine R; Frederick, Amy; Lauer, Andreas; Tsang, Stephen H; Hauswirth, William W; McGill, Trevor J; Neuringer, Martha; Michalakis, Stylianos; Petersen-Jones, Simon M.

Mol Ther ; 31(7): 2028-2041, 2023 07 05.

Artigo Inglês | MEDLINE | ID: mdl-37056049

14.

Development of the intelligent knee osteoarthritis lifestyle app: a person-based approach.

Stevenson, Richard D M; Chowdhury, Enhad A; Inza, Victor B; Western, Max J; Walsh, Nicola E; Jones, Simon L; Bilzon, James L J.

BMC Musculoskelet Disord ; 25(1): 189, 2024 Mar 02.

Artigo Inglês | MEDLINE | ID: mdl-38431553

15.

Techniques for subretinal injections in animals.

Boyd, Ryan F; Petersen-Jones, Simon M.

Vet Ophthalmol ; 2024 May 03.

Artigo Inglês | MEDLINE | ID: mdl-38700998

16.

Consensus guidelines for nomenclature of companion animal inherited retinal disorders.

Mowat, Freya M; Iwabe, Simone; Aguirre, Gustavo D; Petersen-Jones, Simon M.

Vet Ophthalmol ; 2024 Feb 09.

Artigo Inglês | MEDLINE | ID: mdl-38334230

17.

The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse.

Frost, Kathryn; Lewis, Jonathan W; Jones, Simon W; Edwards, James R; Naylor, Amy J; McGettrick, Helen M.

Int J Mol Sci ; 25(10)2024 May 08.

Artigo Inglês | MEDLINE | ID: mdl-38791156

18.

Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.

Cogné, Benjamin; Latypova, Xenia; Senaratne, Lokuliyanage Dona Samudita; Martin, Ludovic; Koboldt, Daniel C; Kellaris, Georgios; Fievet, Lorraine; Le Meur, Guylène; Caldari, Dominique; Debray, Dominique; Nizon, Mathilde; Frengen, Eirik; Bowne, Sara J; Cadena, Elizabeth L; Daiger, Stephen P; Bujakowska, Kinga M; Pierce, Eric A; Gorin, Michael; Katsanis, Nicholas; Bézieau, Stéphane; Petersen-Jones, Simon M; Occelli, Laurence M; Lyons, Leslie A; Legeai-Mallet, Laurence; Sullivan, Lori S; Davis, Erica E; Isidor, Bertrand.

Am J Hum Genet ; 106(6): 893-904, 2020 06 04.

Artigo Inglês | MEDLINE | ID: mdl-32386558

19.

Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC.

O'Leary, Claire; Forte, Gabriella; Mitchell, Nadia L; Youshani, Amir Saam; Dyer, Adam; Wellby, Martin P; Russell, Katharina N; Murray, Samantha J; Jolinon, Nelly; Jones, Simon A; Stacey, Kevin; Davis, Daniel M; Henckaerts, Els; Palmer, David N; Kamaly-Asl, Ian; Bigger, Brian W.

J Transl Med ; 21(1): 437, 2023 07 05.

Artigo Inglês | MEDLINE | ID: mdl-37407981

20.

Continuity of Care Versus Language Concordance as an Intervention to Reduce Hospital Readmissions From Home Health Care.

Squires, Allison; Engel, Patrick; Ma, Chenjuan; Miner, Sarah M; Feldman, Penny H; McDonald, Margaret V; Jones, Simon A.

Med Care ; 61(9): 605-610, 2023 09 01.

Artigo Inglês | MEDLINE | ID: mdl-37561604

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