The burden and epidemiology of community-acquired central nervous system infections: a multinational study.

Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.

Cosmetics considered in the context of physical attractiveness: a review.

Synopsis This review demonstrates the importance of outward appearance (especially of the face and head) in physical attractiveness and describes the methodology and results of objective experiments which assess interpersonal attraction, others' perceptions of the physically attractive and self-perception. It shows that, although cosmetics have been used, inter alia, to manipulate physical attractiveness in some of these experiments, there are little data showing benefit of cosmetics per se to the individual. Consequently, the review is a first step in designing objective studies to test the hypothesis that cosmetics are of demonstrable benefit to the user.

The effects of cosmetics on person perception.

(1)The use of cosmetics (facial make-up and hair care) leads to more favourable appearance ratings by others (both males and females). For make-up there were more favourable ratings on all of the six appearance scales, and for hair care there were more favourable ratings on four of the six appearance scales. (2)The use of cosmetics leads to more favourable ratings of personality as perceived by others (both males and females). Facial make-up enhanced ratings on eight of the fourteen personality dimensions tested and hair treatment led to more favourable ratings on ten of the scales.