Pesquisa | Secretaria de Estado da Saúde

1.

An atlas of cells in the human tonsil.

Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Lunazzi, Giulia; Colomer, Dolors; Frigola, Gerard; Blevins, Will; Romero-Rivero, Lucia; Jiménez-Martínez, Víctor; Vidal, Anna; Mateos-Jaimez, Judith; Maiques-Diaz, Alba; Ovejero, Sara; Moreaux, Jérôme; Palomino, Sara; Gomez-Cabrero, David; Agirre, Xabier; Weniger, Marc A; King, Hamish W; Garner, Lucy C; Marini, Federico; Cervera-Paz, Francisco Javier; Baptista, Peter M; Vilaseca, Isabel; Rosales, Cecilia; Ruiz-Gaspà, Silvia; Talks, Benjamin; Sidhpura, Keval; Pascual-Reguant, Anna; Hauser, Anja E; Haniffa, Muzlifah; Prosper, Felipe; Küppers, Ralf; Gut, Ivo Glynne; Campo, Elias; Martin-Subero, José Ignacio; Heyn, Holger.

Immunity ; 57(2): 379-399.e18, 2024 Feb 13.

Artigo Inglês | MEDLINE | ID: mdl-38301653

2.

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.

Thurner, Lorenz; Fadle, Natalie; Regitz, Evi; Roth, Sophie; Cetin, Onur; Kos, Igor Age; Hess, Simon Mauro; Bein, Julia; Bohle, Rainer Maria; Vornanen, Martine; Sundström, Christer; De Leval, Laurence; Tiacci, Enrico; Borchmann, Peter; Engert, Andreas; Poeschel, Viola; Held, Gerhard; Schwarz, Eva C; Neumann, Frank; Preuss, Klaus-Dieter; Hoth, Markus; Küppers, Ralf; Lehman, Karola; Hansmann, Martin-Leo; Becker, Sören L; Bewarder, Moritz; Hartmann, Sylvia.

Haematologica ; 108(12): 3347-3358, 2023 Dec 01.

Artigo Inglês | MEDLINE | ID: mdl-37139600

3.

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.

Lopez, Cristina; Schleussner, Nikolai; Bernhart, Stephan H; Kleinheinz, Kortine; Sungalee, Stephanie; Sczakiel, Henrike L; Kretzmer, Helene; Toprak, Umut H; Glaser, Selina; Wagener, Rabea; Ammerpohl, Ole; Bens, Susanne; Giefing, Maciej; Sanchez, Juan C Gonzalez; Apic, Gordana; Hubschmann, Daniel; Janz, Martin; Kreuz, Markus; Mottok, Anja; Muller, Judith M; Seufert, Julian; Hoffmann, Steve; Korbel, Jan O; Russell, Robert B; Schule, Roland; Trumper, Lorenz; Klapper, Wolfram; Radlwimmer, Bernhard; Lichter, Peter; Kuppers, Ralf; Schlesner, Matthias; Mathas, Stephan; Siebert, Reiner.

Haematologica ; 108(2): 543-554, 2023 02 01.

Artigo Inglês | MEDLINE | ID: mdl-35522148

4.

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.

Zhang, Xiang; Schuhmachers, Patrick; Mourão, André; Giansanti, Piero; Murer, Anita; Thumann, Sybille; Kuklik-Roos, Cornelia; Beer, Sophie; Hauck, Stefanie M; Hammerschmidt, Wolfgang; Küppers, Ralf; Kuster, Bernhard; Raab, Monika; Strebhardt, Klaus; Sattler, Michael; Münz, Christian; Kempkes, Bettina.

EMBO Rep ; 22(12): e53007, 2021 12 06.

Artigo Inglês | MEDLINE | ID: mdl-34605140

5.

Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics.

Budeus, Bettina; Kibler, Artur; Brauser, Martina; Homp, Ekaterina; Bronischewski, Kevin; Ross, J Alexander; Görgens, Andre; Weniger, Marc A; Dunst, Josefine; Kreslavsky, Taras; Vitoriano da Conceição Castro, Symone; Murke, Florian; Oakes, Christopher C; Rusch, Peter; Andrikos, Dimitrios; Kern, Peter; Köninger, Angela; Lindemann, Monika; Johansson, Patricia; Hansen, Wiebke; Lundell, Anna-Carin; Rudin, Anna; Dürig, Jan; Giebel, Bernd; Hoffmann, Daniel; Küppers, Ralf; Seifert, Marc.

J Immunol ; 206(12): 2839-2851, 2021 06 15.

Artigo Inglês | MEDLINE | ID: mdl-34117106

6.

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes.

Nadeu, Ferran; Martin-Garcia, David; Clot, Guillem; Díaz-Navarro, Ander; Duran-Ferrer, Martí; Navarro, Alba; Vilarrasa-Blasi, Roser; Kulis, Marta; Royo, Romina; Gutiérrez-Abril, Jesús; Valdés-Mas, Rafael; López, Cristina; Chapaprieta, Vicente; Puiggros, Montserrat; Castellano, Giancarlo; Costa, Dolors; Aymerich, Marta; Jares, Pedro; Espinet, Blanca; Muntañola, Ana; Ribera-Cortada, Inmaculada; Siebert, Reiner; Colomer, Dolors; Torrents, David; Gine, Eva; López-Guillermo, Armando; Küppers, Ralf; Martin-Subero, Jose I; Puente, Xose S; Beà, Sílvia; Campo, Elias.

Blood ; 136(12): 1419-1432, 2020 09 17.

Artigo Inglês | MEDLINE | ID: mdl-32584970

7.

Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells.

Uhl, Barbara; Prochazka, Katharina T; Pansy, Katrin; Wenzl, Kerstin; Strobl, Johanna; Baumgartner, Claudia; Szmyra, Marta M; Waha, James E; Wolf, Axel; Tomazic, Peter V; Steinbauer, Elisabeth; Steinwender, Maria; Friedl, Sabine; Weniger, Marc; Küppers, Ralf; Pichler, Martin; Greinix, Hildegard T; Stary, Georg; Ramsay, Alan G; Apollonio, Benedetta; Feichtinger, Julia; Beham-Schmid, Christine; Neumeister, Peter; Deutsch, Alexander J.

Int J Mol Sci ; 23(14)2022 Jul 17.

Artigo Inglês | MEDLINE | ID: mdl-35887224

8.

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.

Montesinos-Rongen, Manuel; Terrao, Monica; May, Caroline; Marcus, Katrin; Blümcke, Ingmar; Hellmich, Martin; Küppers, Ralf; Brunn, Anna; Deckert, Martina.

Haematologica ; 106(3): 708-717, 2021 03 01.

Artigo Inglês | MEDLINE | ID: mdl-32193251

9.

Targeting mRNA translation in CLL.

Küppers, Ralf.

Blood ; 141(26): 3129-3130, 2023 06 29.

Artigo Inglês | MEDLINE | ID: mdl-37383005

10.

Critical influences on the pathogenesis of follicular lymphoma.

Küppers, Ralf; Stevenson, Freda K.

Blood ; 131(21): 2297-2306, 2018 05 24.

Artigo Inglês | MEDLINE | ID: mdl-29666116

11.

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals.

Tucci, Felicia A; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpass, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf.

Blood ; 131(5): 546-557, 2018 02 01.

Artigo Inglês | MEDLINE | ID: mdl-29242186

12.

IG-MYC ⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

Wagener, Rabea; López, Cristina; Kleinheinz, Kortine; Bausinger, Julia; Aukema, Sietse M; Nagel, Inga; Toprak, Umut H; Seufert, Julian; Altmüller, Janine; Thiele, Holger; Schneider, Christof; Kolarova, Julia; Park, Jeongbin; Hübschmann, Daniel; Murga Penas, Eva M; Drexler, Hans G; Attarbaschi, Andishe; Hovland, Randi; Kjeldsen, Eigil; Kneba, Michael; Kontny, Udo; de Leval, Laurence; Nürnberg, Peter; Oschlies, Ilske; Oscier, David; Schlegelberger, Brigitte; Stilgenbauer, Stephan; Wössmann, Wilhelm; Schlesner, Matthias; Burkhardt, Birgit; Klapper, Wolfram; Jaffe, Elaine S; Küppers, Ralf; Siebert, Reiner.

Blood ; 132(21): 2280-2285, 2018 11 22.

Artigo Inglês | MEDLINE | ID: mdl-30282799

13.

CD30 expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis of Hodgkin lymphoma.

Hartmann, Sylvia; Goncharova, Olga; Portyanko, Anna; Sabattini, Elena; Meinel, Jörn; Küppers, Ralf; Agostinelli, Claudio; Pileri, Stefano Aldo; Hansmann, Martin-Leo.

Mod Pathol ; 32(1): 37-47, 2019 01.

Artigo Inglês | MEDLINE | ID: mdl-30140037

14.

Distinct t(14;19) translocation patterns in atypical chronic lymphocytic leukemia and marginal zone lymphomas.

Küppers, Ralf.

Haematologica ; 109(2): 376-378, 2024 Feb 01.

Artigo Inglês | MEDLINE | ID: mdl-37608774

15.

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.

Schuhmacher, Bianca; Bein, Julia; Rausch, Tobias; Benes, Vladimir; Tousseyn, Thomas; Vornanen, Martine; Ponzoni, Maurilio; Thurner, Lorenz; Gascoyne, Randy; Steidl, Christian; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia.

Haematologica ; 104(2): 330-337, 2019 02.

Artigo Inglês | MEDLINE | ID: mdl-30213827

16.

Sugar-modified B-cell receptors in DLBCL.

Küppers, Ralf.

Blood ; 138(17): 1512-1514, 2021 10 28.

Artigo Inglês | MEDLINE | ID: mdl-34709382

17.

OBF1 and OCT1/2 regulate the germinal center B-cell program.

Küppers, Ralf.

Blood ; 137(21): 2862-2863, 2021 05 27.

Artigo Inglês | MEDLINE | ID: mdl-34042984

18.

Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.

Mansouri, Larry; Noerenberg, Daniel; Young, Emma; Mylonas, Elena; Abdulla, Maysaa; Frick, Mareike; Asmar, Fazila; Ljungström, Viktor; Schneider, Markus; Yoshida, Kenichi; Skaftason, Aron; Pandzic, Tatjana; Gonzalez, Blanca; Tasidou, Anna; Waldhueter, Nils; Rivas-Delgado, Alfredo; Angelopoulou, Maria; Ziepert, Marita; Arends, Christopher Maximilian; Couronné, Lucile; Lenze, Dido; Baldus, Claudia D; Bastard, Christian; Okosun, Jessica; Fitzgibbon, Jude; Dörken, Bernd; Drexler, Hans G; Roos-Weil, Damien; Schmitt, Clemens A; Munch-Petersen, Helga D; Zenz, Thorsten; Hansmann, Martin-Leo; Strefford, Jonathan C; Enblad, Gunilla; Bernard, Olivier A; Ralfkiaer, Elisabeth; Erlanson, Martin; Korkolopoulou, Penelope; Hultdin, Magnus; Papadaki, Theodora; Grønbæk, Kirsten; Lopez-Guillermo, Armando; Ogawa, Seishi; Küppers, Ralf; Stamatopoulos, Kostas; Stavroyianni, Niki; Kanellis, George; Rosenwald, Andreas; Campo, Elias; Amini, Rose-Marie.

Blood ; 128(23): 2666-2670, 2016 12 08.

Artigo Inglês | MEDLINE | ID: mdl-27670424

19.

Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes.

Saeedghalati, Mohammadkarim; Farahpour, Farnoush; Budeus, Bettina; Lange, Anja; Westendorf, Astrid M; Seifert, Marc; Küppers, Ralf; Hoffmann, Daniel.

PLoS Comput Biol ; 13(1): e1005362, 2017 01.

Artigo Inglês | MEDLINE | ID: mdl-28114391

20.

TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.

Schwartz, Friederike H; Cai, Qian; Fellmann, Eva; Hartmann, Sylvia; Mäyränpää, Mikko I; Karjalainen-Lindsberg, Marja-Liisa; Sundström, Christer; Scholtysik, René; Hansmann, Martin-Leo; Küppers, Ralf.

J Pathol ; 242(2): 129-133, 2017 06.

Artigo Inglês | MEDLINE | ID: mdl-28337768

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An atlas of cells in the human tonsil.

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.

Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics.

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes.

Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells.

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.

Targeting mRNA translation in CLL.

Critical influences on the pathogenesis of follicular lymphoma.

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals.

IG-MYC ⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

CD30 expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis of Hodgkin lymphoma.

Distinct t(14;19) translocation patterns in atypical chronic lymphocytic leukemia and marginal zone lymphomas.

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.

Sugar-modified B-cell receptors in DLBCL.

OBF1 and OCT1/2 regulate the germinal center B-cell program.

Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.

Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes.

TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.